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Vol. 13.00 – 10 January, 2024
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Investigators showed that lymphatic endothelial-like cells, while previously unrecognized in brain parenchyma, were present in glioblastomas and promoted growth of CCR7-positive glioblastoma stem cells through CCL21 secretion.
[Nature Cancer]
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PUBLICATIONSRanked by the impact factor of the journal
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Researchers showed that transmembrane and immunoglobulin domain containing 2 (TMIGD2), a recently discovered co-stimulatory immune receptor, was aberrantly expressed by human AML cells, and could be used to identify and enrich functional leukemia stem cells.
[Nature Communications]
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Scientists demonstrated that peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (Pin1) was deubiquitinated and stabilized by USP34, which promoted isomerization of the sole SUMO E2 enzyme Ubc9, leading to SUMO1-modified hypersumoylation to support glioma stem cell maintenance.
[Nature Communications]
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Using heterotypic cancer associated fibroblast (CAF)-ovarian cancer (OC) cocultures and in vivo limiting dilution assay, the authors confirmed that the CAFs acted by enriching the CSC population.
[npj Precision Oncology]
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By combining RNA sequencing with proteome-wide label-free quantification, investigators reported that MALT1 repression in patient-derived glioblastoma stem-like cells altered the homeostasis of cholesterol, which accumulated in late endosomes-lysosomes.
[Cell Reports]
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Scientists found that inducible inhibition of β-catenin suppressed elongation of Pol II and RNA polymerase-associated factor 1 complex (PAF1C) around the transcription start site (TSS) of LGR5.
[Oncogene]
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Tumor tissues of 212 breast cancer patients were subjected to tissue microarray and further assessed the associations of tandem C2 domains, nuclear (TC2N) expression with pathological parameters and FASN expression.
[Journal of Translational Medicine]
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In screening for small molecules, the authors identified salinomycin, an inducer of ferroptosis, as a potent inhibitor of MUC1-C signaling.
[Cell Death Discovery]
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RNA-seq was performed to elucidate transcriptional alterations between desmoplastic small round cell tumor cells grown in CSC-like spheres and normal 2-dimensional adherent state.
[Oncogenesis]
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Investigators summarize the latest published research on resveratrol’s effect in the prevention of CRC, its regulatory actions, specifically on the p53 pathway, and its treatment options.
[Journal of Advanced Research]
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The BEST4 trial launched at Addenbrooke’s Hospital was the final step to see if the capsule sponge, known as the pill-on-a-thread, can prevent oesophageal cancer when used to screen or monitor those most at risk of the disease.
[University of Cambridge]
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Dr. Elizabeth E. Brown and Dr. Lalita Shevde-Samant are co-leading a new research education program entitled University of Alabama at Birmingham Enhancing Research in Cancer-related Health Professions with support from the National Cancer Institute.
[The University of Alabama at Birmingham]
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February 22 – 24, 2024
Rotterdam, Netherlands
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Human Technopole – Milan, Italy
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MD Anderson Cancer Center – Houston, Texas, United States
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H. Lee Moffitt Cancer Center & Research Institute – Tampa, Florida, United States
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Michigan State University – East Lansing, Michigan, United States
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Jinfeng Labs & Institute of Functional Genomics – Chongqing, China
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