Cancer Stem Cell News Volume 13.01 | Jan 16 2024


    2024-11-17 | CSCN 13.02

    Cancer Stem Cell News by STEMCELL Technologies
    Vol. 13.01 – 16 January, 2024

    LASS2 Enhances Chemosensitivity to Cisplatin by Inhibiting PP2A-Mediated β-Catenin Dephosphorylation in a Subset of Stem-Like Bladder Cancer Cells

    Flow cytometry was used to sort and analyze bladder cancer stem cells. Tumor sphere formation, soft agar colony formation assay, EdU assay, apoptosis analysis, cell viability, and cisplatin sensitivity assay were used to investigate the functional roles of LASS2.
    [BMC Medicine]

    Full Article
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    EXOSC5 Maintains Cancer Stem Cell Activity in Endometrial Cancer by Regulating the NTN4/Integrin β1 Signaling Axis

    Data from The Cancer Genome Atlas suggests a correlation between high EXOSC5 mRNA expression and unfavorable endometrial carcinoma prognosis.
    [International Journal Of Biological Sciences]

    Full Article

    VEGFA/NRP-1/GAPVD1 Axis Promotes Progression and Cancer Stemness of Triple-Negative Breast Cancer by Enhancing Tumor Cell-Macrophage Crosstalk

    Scientists reported that M2-type tumor-associated macrophages contributed to cancer stemness in triple-negative breast cancer cells via the secretion of VEGFA.
    [International Journal Of Biological Sciences]

    Full ArticleGraphical Abstract

    Novel Cellular Systems Unveil Mucosal Melanoma Initiating Cells and a Role for PI3K/Akt/mTOR Pathway in Mucosal Melanoma Fitness

    Five novel cell lines were obtained from patient-derived biopsies of mucosal melanomas (MM) arising in the sino-nasal mucosa and designated as SN-MM1-5. The morphology, ultrastructure and melanocytic identity of SN-MM cell lines were validated by transmission electron microscopy and immunohistochemistry.
    [Journal Of Translational Medicine]

    Full Article

    GCF2 Mediates Nicotine-Induced Cancer Stemness and Progression in Hepatocellular Carcinoma

    The authors reported that nicotine enhanced hepatocellular carcinoma cancer stemness and malignant progression by upregulating the expression of GC-rich binding factor 2 (GCF2) and subsequently activating the Wnt/ꞵ-catenin/SOX2 signaling pathway.
    [Ecotoxicology and Environmental Safety]

    Full Article

    LncRNA FOXD1-AS1 Regulates Pancreatic Cancer Stem Cell Properties and 5-FU Resistance by Regulating the miR-570-3p/SPP1 Axis as a ceRNA

    Investigators identified an upregulation of lncRNA FOXD1-AS1 in CSCs. The enforced expression of lncRNA FOXD1-AS1 promotes tumorigenesis and self-renewal in pancreatic cancer CSCs.
    [Cancer Cell International]

    Full Article

    Cancer-Associated Fibroblasts Promote Stemness Maintenance and Gemcitabine Resistance via HIF-1α/miR-21 Axis under Hypoxic Conditions in Pancreatic Cancer

    Researchers probed the mechanism of hypoxia-treated cancer-associated fibroblasts regulating cell stemness and gemcitabine resistance in pancreatic cancer.
    [Molecular Carcinogenesis]


    Transcriptomics Analysis Reveals Distinct Mechanism of Breast Cancer Stem Cells Regulation in Mammospheres from MCF-7 and T47D Cells

    Scientists elucidated the transcriptomic disparities between mammospheres of MCF-7 and T47D cells using bioinformatics analyses of differentially expressed genes.

    Full Article

    LncRNA H19 Participates in Leukemia Inhibitory Factor Mediated Stemness Promotion in Colorectal Cancer Cells

    Investigators observed that leukemia inhibitory factor could increase the spheroid formation and stemness marker expression in colorectal cancer cell lines, such as HCT116 and Caco2 cells.
    [Biochemical Genetics]

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    Bridging Tissue Repair and Epithelial Carcinogenesis: Epigenetic Memory and Field Cancerization

    Scientists review the similarities between tissue repair and carcinogenesis, with a special focus on the epigenetic mechanisms activated by cells during repair and opted by carcinoma cells in multiple epithelia.
    [Cell Death & Differentiation]


    Cancer Stem Cell Biomarkers and Related Signaling Pathways

    The authors consolidate the latest findings on CSCs biomarkers, targeted agents as well as biomarkers associated signaling pathways in well-established cancer types, thereby contributing to improved prognostic outcomes.
    [Journal Of Drug Targeting]


    European Commission Approves Roche’s Tecentriq SC, the EU’s First PD-(L)1 Cancer Immunotherapy Subcutaneous Injection for Multiple Cancer Types

    Until now, Tecentriq has been given directly into patients’ veins by IV infusion which takes approximately 30-60 minutes. The new subcutaneous injection will cut treatment time to approximately seven minutes, with most injections taking between four and eight minutes.

    Press Release

    UCLA Cancer Center Wins Grants

    It was announced that researchers at UCLA Health Jonsson Comprehensive Cancer Center received two grants totaling $9.1 million from the National Cancer Institute to advance liquid biopsy technologies for the early detection of cancer.
    [Los Angeles Business Journal]

    Press Release

    2024 SITC Spring Scientific

    March 10 – 12, 2024
    Miami, Florida, United States & Virtual

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    Postdoctoral Researchers – Advanced Imaging & 3D Genome Analysis in Cancer Biology

    Karolinska Institutet – Solna, Sweden

    Postdoctoral Fellow – Intestinal Stem Cells and Cancer

    The Francis Crick Institute – London, England, United Kingdom

    Postdoctoral Fellow – Tumor Microenvironment and Leukemia

    City of Hope – Duarte, California, United States

    Research Assistant – Hematopoietic Biology & Malignancy

    MD Anderson Cancer Center – Houston, Texas, United States

    Research Associate – Translational Pediatric Oncology

    City of Hope – Duarte, California, United States

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