Cancer Stem Cell News Volume 13.02 | Jan 24 2024

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    2024-01-24 | CSCN 13.03


    Cancer Stem Cell News by STEMCELL Technologies
    Vol. 13.03 – 24 January, 2024
    TOP STORY

    A Telomere-Targeting Drug Depletes Cancer Initiating Cells and Promotes Anti-Tumor Immunity in Small Cell Lung Cancer

    Using preclinical mouse and human-derived models, investigators found low intermittent doses of 6-Thio-2’-deoxyguanosine inhibit tumor growth and reduce metastatic burden.
    [Nature Communications]

    Full Article
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    Activating p53 Abolishes Self-Renewal of Quiescent Leukemic Stem Cells in Residual CML Disease

    Scientists demonstrated that the regulatory programs of quiescent leukemic stem cell (LSC) in chronic phase chronic myeloid leukemia (CML) are similar to that of embryonic stem cells, pointing to a role for wild type p53 in LSC self-renewal.
    [Nature Communications]

    Full Article

    The Impact of Circulating Tumor Cell HOXB13 RNA Detection in Men with Metastatic Castration-Resistant Prostate Cancer Treated with Abiraterone or Enzalutamide

    Researchers conducted a retrospective analysis of the multicenter prospective PROPHECY trial of metastatic castration-resistant prostate cancer men treated with abiraterone/enzalutamide.
    [Clinical Cancer Research]

    Abstract

    N6-Methyladenosine Reader YTHDF1 Promotes Stemness and Therapeutic Resistance in Hepatocellular Carcinoma by Enhancing NOTCH1 Expression

    The authors evaluated the clinical significance of YTHDF1 using human hepatocellular carcinoma (HCC) samples and found that YTHDF1 was significantly upregulated in HCCs with high stemness scores and was positively associated with recurrence and poor prognosis.
    [Cancer Research]

    Abstract

    The Dopamine Receptor D1 Inhibitor, SKF83566, Suppresses GBM Stemness and Invasion through the DRD1-C-Myc-UHRF1 Interactions

    GFP-labeled tumor cells were sorted from invasive and non-invasive regions within co-cultures. Ui-RNA sequencing analysis was performed to find a gene cluster up-regulated in the invasive compartment.
    [Journal of Experimental & Clinical Cancer Research]

    Full Article

    c-MET-Positive Circulating Tumor Cells and Cell-Free DNA as Independent Prognostic Factors in Hormone Receptor-Positive/HER2-Negative Metastatic Breast Cancer

    Ninety-seven patients with hormone receptor-positive metastatic breast cancer were prospectively enrolled during standard treatment at Samsung Medical Center.
    [Breast Cancer Research]

    Full Article

    N6-Methyladenosine-Modified MIB1 Promotes Stemness Properties and Peritoneal Metastasis of Gastric Cancer Cells by Ubiquitinating DDX3X

    The effect of mind bomb 1 (MIB1) on peritoneal metastasis of gastric cancer was confirmed in vitro and in vivo. Co-immunoprecipitation and mass spectrometry demonstrated the association between MIB1 and DEAD-box helicase 3 X-linked (DDX3X).
    [Gastric Cancer]

    Abstract

    m6A Demethylase ALKBH5 Maintains Stemness of Intrahepatic Cholangiocarcinoma by Sustaining BUB1B Expression and Cell Proliferation

    Bioinformatic analyses of The Cancer Genome Atlas data were performed, and the association of alkB homolog 5 (ALKBH5) in predicting overall survival in patients with intrahepatic cholangiocarcinoma was investigated.
    [Translational Oncology]

    Full ArticleGraphical Abstract

    Integrin-Associated Transcriptional Characteristics of Circulating Tumor Cells in Breast Cancer Patients

    Single-cell RNA sequencing of CD45-negative cell fraction of breast cancer patients was performed. All circulating tumor cells were divided into nine groups according to their integrin profile.
    [PeerJ]

    Full Article
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    REVIEWS

    Crosstalk between Colorectal CSCs and Immune Cells in Tumorigenesis, and Strategies for Targeting Colorectal CSCs

    The mutual interactions between CSCs and cancer niche immune cells are largely uncharacterized. The authors focus on colorectal CSCs, CSC-immune cell interactions, and CSC-based immunotherapy.
    [Experimental Hematology & Oncology]

    Full Article
    INDUSTRY AND POLICY NEWS

    Canadian Cancer Society Awards Two UM Emerging Scholars

    Dr. Tara Horrill and Dr. Joel Pearson at the Rady Faculty of Health Sciences were among the winners of the Canadian Cancer Society’s 2023 Emerging Scholar Research Grants competition.
    [University of Manitoba]

    Press Release

    Penn Medicine’s E. John Wherry, PhD, and CHOP’s John M. Maris, MD, named 2024 Fellows of the AACR Academy

    Renowned immunologist E. John Wherry, PhD, and distinguished pediatric oncologist John M. Maris, MD, have been named as members of the 2024 class of fellows of the American Association for Cancer Research (AACR) Academy.
    [University of Pennsylvania]

    Press Release
    FEATURED EVENT

    London Biotechnology Show 2024

    February 27 – 28, 2024
    London, England, United Kingdom

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Fellow – Cancer and Metabolic Reprogramming

    Thomas Jefferson University – Philadelphia, Pennsylvania, United States

    Postdoctoral Position – Predictive Models for Anti-Cancer Therapeutic Target Prioritization

    Human Technopole – Milan, Italy

    Laboratory Technician – Radiation Oncology

    MD Anderson Cancer Center – Houston, Texas, United States

    Postdoctoral Researchers – Advanced Imaging & 3D Genome Analysis in Cancer Biology

    Karolinska Institutet – Solna, Sweden

    Research Fellow – Structural Biology of RNA

    University of Birmingham – Birmingham, England, United Kingdom

    > See All Jobs

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