Cancer Stem Cell News Volume 13.03 | Jan 31 2024

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    2024-01-31 | CSCN 13.03


    Cancer Stem Cell News by STEMCELL Technologies
    Vol. 13.03 – 31 January, 2024
    TOP STORY

    PI3Kγ Maintains the Self-Renewal of Acute Myeloid Leukemia Stem Cells by Regulating the Pentose Phosphate Pathway

    Scientists found that while PI3Kγ was highly enriched in leukemia stem cells and critical for self-renewal, it was dispensable for normal hematopoietic stem cells.
    [Blood]

    Abstract
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    PUBLICATIONSRanked by the impact factor of the journal

    An NFAT1-C3a-C3aR Positive Feedback Loop in Tumor-Associated Macrophages Promotes a Glioma Stem Cell Malignant Phenotype

    The authors showed that the antitumor immune microenvironment was activated in glioma in Nfat1−/− mice, suggesting induction of the immune-suppressive microenvironment by nuclear factor of activated T cells-1 (NFAT1).
    [Cancer Immunology Research]

    Abstract

    Fbxw7 Suppresses Carcinogenesis and Stemness in Triple-Negative Breast Cancer through CHD4 Degradation and Wnt/β-Catenin Pathway Inhibition

    Researchers detected F-box and WD repeat domain-containing 7 (FBXW7) by immunohistochemistry in 80 triple-negative breast cancer patients. FBXW7 knockdown and overexpression in MD-MBA-231 and HCC1937 cell models were constructed.
    [Journal of Translational Medicine]

    Full Article

    Inhibition of Proprotein Convertases Activity Results in Repressed Stemness and Invasiveness of Cancer Stem Cells in Gastric Cancer

    The general proprotein convertases (PCs) inhibitor, decanoyl-RVKR-chloromethyl-ketone, was used to repress PCs activity in CSCs of various gastric cancer cell lines.
    [Gastric Cancer]

    Abstract

    Role of Catecholamine Synthases in the Maintenance of Cancer Stem-Like Cells in Malignant Peripheral Nerve Sheath Tumors

    Scientists found that malignant peripheral nerve sheath tumors cells expressed catecholamine synthases and that these enzymes were essential for maintaining cancer stemness, such as the ability to self-renew and maintain an undifferentiated state.
    [Cancer Science]

    Full Article

    Construction and In Vitro Evaluation of pH-Sensitive Nanoparticles to Reverse Drug Resistance of Breast Cancer Stem Cells

    Schisandrin B (SchB)/AP NPs were constructed using acid-grafted-poly (β-amino ester) grafted polymer nanoparticle encapsulated SchB, with pH-sensitive release function.
    [Discover Oncology]

    Full Article

    Sphingomyelin Synthase 2 Promotes the Stemness of Breast Cancer Cells via Modulating NF-κB Signaling Pathway

    Quantitative RT-PCR analysis was performed to assess changes in mRNA expression. Western blot analysis was performed to detect protein expression.
    [Journal Of Cancer Research And Clinical Oncology]

    Full Article

    The m6A Methyltransferase RBM15 Affects Tumor Cell Stemness and Progression of Cervical Cancer by Regulating the Stability of lncRNA HEIH

    The TCGA database was used to screen differentially expressed m6A genes in normal and tumor tissues. QRT-PCR was used to quantify HEIH, miR-802, EGFR, cell stemness, and epithelial-mesenchymal transition-related genes.
    [Experimental Cell Research]

    AbstractGraphical Abstract

    Exposure of Piperlongumine Attenuates Stemness and Epithelial to Mesenchymal Transition Phenotype with More Potent Anti-Metastatic Activity in SOX9 Deficient Human Lung Cancer Cells

    Researchers reconnoitered the anti-lung cancer effect of piperlongumine and the allied mechanisms, in vitro and ex vivo.
    [Naunyn-Schmiedebergs Archives Of Pharmacology]

    AbstractGraphical Abstract

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    REVIEWS

    Clinical Applications of Circulating Tumor Cells in Patients with Solid Tumors

    The authors critically review the current implications of liquid biopsy, with a special focus on circulating tumor cells, and describe the hurdles that need to be addressed before liquid biopsy can be implemented in clinical standard-of-care guidelines.
    [Clinical & Experimental Metastasis]

    Full Article
    INDUSTRY AND POLICY NEWS

    State-of-the-Art Technology Enhances Cancer Diagnostics, Research, Care

    Cancer patients and their families will benefit from more access to life-saving cancer diagnostics as new equipment and research expand access to PET/CT scans and innovative cancer treatments throughout the province.
    [BC Gov News]

    Press Release

    NHS Offers First Drug Targeting Advanced Breast Cancers Driven by BRCA Gene Mutations

    Talazoparib will become the NHS’s first targeted treatment for advanced breast cancers caused by mutations to BRCA genes, after a recommendation by the National Institute for Health and Care Excellence.
    [Cancer Research UK]

    Press Release
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