| Vol. 13.03 – 31 January, 2024 |
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| Scientists found that while PI3Kγ was highly enriched in leukemia stem cells and critical for self-renewal, it was dispensable for normal hematopoietic stem cells. [Blood] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| The authors showed that the antitumor immune microenvironment was activated in glioma in Nfat1−/− mice, suggesting induction of the immune-suppressive microenvironment by nuclear factor of activated T cells-1 (NFAT1). [Cancer Immunology Research] |
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| Researchers detected F-box and WD repeat domain-containing 7 (FBXW7) by immunohistochemistry in 80 triple-negative breast cancer patients. FBXW7 knockdown and overexpression in MD-MBA-231 and HCC1937 cell models were constructed. [Journal of Translational Medicine] |
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| The general proprotein convertases (PCs) inhibitor, decanoyl-RVKR-chloromethyl-ketone, was used to repress PCs activity in CSCs of various gastric cancer cell lines. [Gastric Cancer] |
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| Scientists found that malignant peripheral nerve sheath tumors cells expressed catecholamine synthases and that these enzymes were essential for maintaining cancer stemness, such as the ability to self-renew and maintain an undifferentiated state. [Cancer Science] |
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| Schisandrin B (SchB)/AP NPs were constructed using acid-grafted-poly (β-amino ester) grafted polymer nanoparticle encapsulated SchB, with pH-sensitive release function. [Discover Oncology] |
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| Quantitative RT-PCR analysis was performed to assess changes in mRNA expression. Western blot analysis was performed to detect protein expression. [Journal Of Cancer Research And Clinical Oncology] |
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| The TCGA database was used to screen differentially expressed m6A genes in normal and tumor tissues. QRT-PCR was used to quantify HEIH, miR-802, EGFR, cell stemness, and epithelial-mesenchymal transition-related genes. [Experimental Cell Research] |
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| Researchers reconnoitered the anti-lung cancer effect of piperlongumine and the allied mechanisms, in vitro and ex vivo. [Naunyn-Schmiedebergs Archives Of Pharmacology] |
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| The authors critically review the current implications of liquid biopsy, with a special focus on circulating tumor cells, and describe the hurdles that need to be addressed before liquid biopsy can be implemented in clinical standard-of-care guidelines. [Clinical & Experimental Metastasis] |
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| Cancer patients and their families will benefit from more access to life-saving cancer diagnostics as new equipment and research expand access to PET/CT scans and innovative cancer treatments throughout the province. [BC Gov News] |
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| Talazoparib will become the NHS’s first targeted treatment for advanced breast cancers caused by mutations to BRCA genes, after a recommendation by the National Institute for Health and Care Excellence. [Cancer Research UK] |
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| March 11 – 13, 2024 Lisbon, Portugal |
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| University of Texas MD Anderson Cancer Center – Houston, Texas, United States |
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| Thomas Jefferson University – Philadelphia, Pennsylvania, United States |
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| Human Technopole – Milan, Italy |
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| Karolinska Institutet – Solna, Sweden |
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| University of Birmingham – Birmingham, England, United Kingdom |
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