 | | Vol. 13.04 – 7 February, 2024 |
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| Liver-specific methyltransferase 16 (Mettl16) conditional knockout mice were generated to assess its role in hepatocellular carcinoma pathogenesis and normal hepatogenesis.
[Journal Of Hematology & Oncology] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers discovered that EMSY, inducing a BRCAness phenotype, was preferentially expressed in breast CSCs, promoted ALDH+ cells enrichment, and was positively correlated with poor relapse-free survival.
[Cell Reports Medicine] |
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| Scientists developed a nanoparticle-assisted combination therapy to eliminate CSCs by employing photodynamic therapy to yield reactive oxygen species (ROS) while disrupting ROS defense with glutaminolysis inhibition.
[Biomaterials] |
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| Researchers showed that the RNA-editing enzyme ADAR1 was a crucial stemness factor that promotes leukemia-initiating cell self-renewal by attenuating aberrant double-stranded RNA sensing.
[Cell Reports] |
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| The expression of USP40 in human hepatocellular carcinoma (HCC) tissues and HCC cell lines was investigated using RT-qPCR, western blotting, and immunohistochemistry.
[Biology Direct] |
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| Investigators found that lncRNA deleted in lymphocytic leukemia-2 (lncRNA DLEU2) and ROR1 were specifically upregulated in tumor tissues compared to their normal counterparts in TCGA, PubMed GEO datasets, and samples from archived breast cancer tumor tissues.
[Cell Death Discovery] |
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| The authors reported that the anti-schistosome agent lucanthone impeded tumor growth in a preclinical model of temozolomide-resistant glioblastoma, and reduced the numbers of stem-like glioma cells.
[Journal of Pharmacology and Experimental Therapeutics] |
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| Cisplatin-resistant cell lines were established using the concentration gradient overlay method, and differentially expressed genes in resistant cells were screened through RNA sequencing.
[Environmental Toxicology] |
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| Commercially available protein arrays were used to determine the cell surface signature of eight stem-like glioma cells (SLGC) lines from glioblastoma multiformes (GBM), one SLGC line obtained from a xenotransplanted GBM-derived SLGC line, and three SLGC lines from gliosarcomas.
[PLOS One] |
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| The authors provide an overview of piRNA biogenesis and critically review the evidence for the role of piRNA-PIWI axis in CSCs.
[Biomarker Research] |
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| The Alberta Cancer Foundation revealed the inaugural recipients of its Game Changer Fund. This transformative initiative aims to accelerate local cancer research by fostering collaboration between researchers and frontline clinicians.
[Alberta Cancer Foundation] |
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| The University of Sheffield and Yorkshire Cancer Research have announced seven world-leading research studies that will aim to help more people survive cancer by exploring new solutions in cancer prevention, diagnosis, and treatment.
[University of Sheffield] |
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| March 18 – 19, 2024
London, England, United Kingdom |
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| | University of Washington – Seattle, Washington, United States |
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| | Dana-Farber – Boston, Massachusetts, United States |
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| | Thomas Jefferson University – Philadelphia, Pennsylvania, United States |
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| | Human Technopole – Milan, Italy |
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| | University of Birmingham – Birmingham, England, United Kingdom |
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