Cancer Stem Cell News Volume 13.04 | Feb 07 2024


    2024-02-07 | CSCN 13.04

    Cancer Stem Cell News by STEMCELL Technologies
    Vol. 13.04 – 7 February, 2024

    METTL16 Promotes Liver Cancer Stem Cell Self-Renewal via Controlling Ribosome Biogenesis and mRNA Translation

    Liver-specific methyltransferase 16 (Mettl16) conditional knockout mice were generated to assess its role in hepatocellular carcinoma pathogenesis and normal hepatogenesis.
    [Journal Of Hematology & Oncology]

    Full Article
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    Targeting EMSY-Mediated Methionine Metabolism Is a Potential Therapeutic Strategy for Triple-Negative Breast Cancer

    Researchers discovered that EMSY, inducing a BRCAness phenotype, was preferentially expressed in breast CSCs, promoted ALDH+ cells enrichment, and was positively correlated with poor relapse-free survival.
    [Cell Reports Medicine]

    Full ArticleGraphical Abstract

    Glutaminolysis Inhibition Boosts Photodynamic Therapy to Eliminate Cancer Stem Cells

    Scientists developed a nanoparticle-assisted combination therapy to eliminate CSCs by employing photodynamic therapy to yield reactive oxygen species (ROS) while disrupting ROS defense with glutaminolysis inhibition.

    AbstractGraphical Abstract

    Malignant A-to-I RNA Editing by ADAR1 Drives T Cell Acute Lymphoblastic Leukemia Relapse via Attenuating dsRNA Sensing

    Researchers showed that the RNA-editing enzyme ADAR1 was a crucial stemness factor that promotes leukemia-initiating cell self-renewal by attenuating aberrant double-stranded RNA sensing.
    [Cell Reports]

    Full ArticleGraphical Abstract

    USP40 Promotes Hepatocellular Carcinoma Cell Proliferation, Migration, and Stemness by Deubiquitinating and Stabilizing Claudin1

    The expression of USP40 in human hepatocellular carcinoma (HCC) tissues and HCC cell lines was investigated using RT-qPCR, western blotting, and immunohistochemistry.
    [Biology Direct]

    Full Article

    Long Noncoding RNA DLEU2 and ROR1 Pathway Induces Epithelial-to-Mesenchymal Transition and Cancer Stem Cells in Breast Cancer

    Investigators found that lncRNA deleted in lymphocytic leukemia-2 (lncRNA DLEU2) and ROR1 were specifically upregulated in tumor tissues compared to their normal counterparts in TCGA, PubMed GEO datasets, and samples from archived breast cancer tumor tissues.
    [Cell Death Discovery]

    Full Article

    Lucanthone, a Potential PPT1 inhibitor, Perturbs Stemness, Reduces Tumor Microtube Formation and Slows the Growth of Temozolomide-Resistant Gliomas In Vivo

    The authors reported that the anti-schistosome agent lucanthone impeded tumor growth in a preclinical model of temozolomide-resistant glioblastoma, and reduced the numbers of stem-like glioma cells.
    [Journal of Pharmacology and Experimental Therapeutics]


    PRDX2 Regulates Stemness Contributing to Cisplatin Resistance and Metastasis in Bladder Cancer

    Cisplatin-resistant cell lines were established using the concentration gradient overlay method, and differentially expressed genes in resistant cells were screened through RNA sequencing.
    [Environmental Toxicology]

    Full Article

    Molecular Signature of Stem-Like Glioma Cells (SLGCs) from Human Glioblastoma and Gliosarcoma

    Commercially available protein arrays were used to determine the cell surface signature of eight stem-like glioma cells (SLGC) lines from glioblastoma multiformes (GBM), one SLGC line obtained from a xenotransplanted GBM-derived SLGC line, and three SLGC lines from gliosarcomas.
    [PLOS One]

    Full Article
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    Critical Appraisal of the piRNA-PIWI Axis in Cancer and Cancer Stem Cells

    The authors provide an overview of piRNA biogenesis and critically review the evidence for the role of piRNA-PIWI axis in CSCs.
    [Biomarker Research]

    Full Article

    A New Era of Cancer Research: Alberta Cancer Foundation Unveils Inaugural Game Changer Fund Recipients

    The Alberta Cancer Foundation revealed the inaugural recipients of its Game Changer Fund. This transformative initiative aims to accelerate local cancer research by fostering collaboration between researchers and frontline clinicians.
    [Alberta Cancer Foundation]

    Press Release

    Future of Cancer Research in Yorkshire Receives £8.9 Million Funding Boost

    The University of Sheffield and Yorkshire Cancer Research have announced seven world-leading research studies that will aim to help more people survive cancer by exploring new solutions in cancer prevention, diagnosis, and treatment.
    [University of Sheffield]

    Press Release

    3D Cell Culture & Organ Modelling 2024

    March 18 – 19, 2024
    London, England, United Kingdom

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    Research Assistant – GI Medical Oncology Research Program

    University of Washington – Seattle, Washington, United States

    Regulatory Coordinator – Breast Oncology

    Dana-Farber – Boston, Massachusetts, United States

    Postdoctoral Fellow – Cancer and Metabolic Reprogramming

    Thomas Jefferson University – Philadelphia, Pennsylvania, United States

    Postdoctoral Position – Predictive Models for Anti-Cancer Therapeutic Target Prioritization

    Human Technopole – Milan, Italy

    Research Fellow – Structural Biology of RNA

    University of Birmingham – Birmingham, England, United Kingdom

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