 | | Vol. 13.05 – 14 February, 2024 |
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| A nanotherapeutic strategy was developed using tumor-penetrating peptide iRGD-modified high-density lipoprotein-mimetic nanodiscs that ingeniously loaded with pyropheophorbide-a, bis (2-hydroxyethyl) disulfide, and camptothecin by synthesizing two amphiphilic drug-conjugated sphingomyelin derivatives.
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators observed that the secretomes of hypoxic breast cancer cells and breast CSCs induced reprogramming of metabolic pathways, particularly glycolysis, in normoxic breast cancer cells.
[Cancer Research] |
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| The essential role of Par-3 Family Cell Polarity Regulator (PARD3) in mediating hepatic tumorigenesis was assessed in diet-induced spontaneous liver tumor and syngeneic tumor models.
[Journal of Experimental & Clinical Cancer Research] |
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| The authors demonstrated that inhibition of tyrosine phosphatase SHP-1 in leukemia stem cells increased their glycolysis and oxidative phosphorylation, enhancing their sensitivity to chemotherapy and vulnerability to immunosurveillance.
[Nature Cell Biology] |
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| Researchers utilized the MMTV-cre, The Ubiquitin Specific Peptidase 22 (Usp22)fl/fl transgenic mouse model to study the involvement of USP22 in the stem cell-like properties of the growing mammary tissue.
[Cell Communication And Signaling] |
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| Scientists employed microfluidic single-cell culture arrays to expand renal cancer stem cells by exploiting the anti-apoptosis and self-renewal properties of tumor stem cells.
[Lab On A Chip] |
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| Gold/silver alloy nanoparticle decorated camptothecin nanocrystals were formulated according to complementary anti-CSC mechanisms from gold, silver, and organic drug.
[Molecular Pharmaceutics] |
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| The bioinformatics method was used to analyze the mRNA and protein expression characteristics of MUC1 in lung adenocarcinoma (LUAD).
[Annals of Medicine] |
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| Researchers revealed that CagA-positive gastric cancer cells infected with H. pylori exhibited CSC-like properties, such as heightened expression of CD44, a specific surface marker for CSCs, and increased ability to form tumor spheroids.
[Journal of Cellular Biochemistry] |
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WWTR1-AS1 expression was upregulated in cervical squamous cell carcinoma (CSCC) tissues. WWTR1-AS1 was predicted to interact with miR-136, whereas correlation analysis revealed that there was no close correlation between WWTR1-AS1 and miR-136 across CSCC samples.
[BMC Womens Health] |
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| The authors explore the intricate landscape of cancer cell plasticity, offering a deep dive into the cellular, molecular, and genetic mechanisms that underlie this phenomenon.
[Cancer and Metastasis Reviews] |
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| UWinnipeg graduate student Hailey Langford is working with Dr. Anuraag Shrivastav, who is committed to changing these grim statistics. Dr. Shrivastav’s research could reduce the mortality rate by creating a new screening test to detect colorectal cancer earlier.
[The University of Winnipeg] |
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| Dr. Sumit Gupta, a physician-scientist whose research focuses on vulnerable subpopulations of children with cancer, has been awarded the eighth annual Gale and Ira Drukier Prize in Children’s Health Research.
[Weill Cornell Medicine] |
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| March 24 – 29, 2024
Galveston, Texas, United States |
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| | UC Davis – Davis, California, United States |
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| | Cyprus Cancer Research Institute – Aglandjia, Cyprus |
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| | Cyprus Cancer Research Institute – Aglandjia, Cyprus |
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| | University of Texas MD Anderson Cancer Center – Houston, Texas, United States |
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| | The Genomics Research Center, Academia Sinica – Taipei City, Taiwan |
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