Cancer Stem Cell News Volume 13.05 | Feb 14 2024


    2024-02-14 | CSCN 13.05

    Cancer Stem Cell News by STEMCELL Technologies
    Vol. 13.05 – 14 February, 2024

    Manipulating Redox Homeostasis of Cancer Stem Cells Overcome Chemotherapeutic Resistance through Photoactivatable Biomimetic Nanodiscs

    A nanotherapeutic strategy was developed using tumor-penetrating peptide iRGD-modified high-density lipoprotein-mimetic nanodiscs that ingeniously loaded with pyropheophorbide-a, bis (2-hydroxyethyl) disulfide, and camptothecin by synthesizing two amphiphilic drug-conjugated sphingomyelin derivatives.

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    Breast Cancer Stem Cells Secrete MIF to Mediate Tumor Metabolic Reprogramming that Drives Immune Evasion

    Investigators observed that the secretomes of hypoxic breast cancer cells and breast CSCs induced reprogramming of metabolic pathways, particularly glycolysis, in normoxic breast cancer cells.
    [Cancer Research]


    PARD3 Drives Tumorigenesis through Activating Sonic Hedgehog Signaling in Tumor-Initiating Cells in Liver Cancer

    The essential role of Par-3 Family Cell Polarity Regulator (PARD3) in mediating hepatic tumorigenesis was assessed in diet-induced spontaneous liver tumor and syngeneic tumor models.
    [Journal of Experimental & Clinical Cancer Research]

    Full Article

    SHP-1 Inhibition Targets Leukemia Stem Cells to Restore Immunosurveillance and Enhance Chemosensitivity by Metabolic Reprogramming

    The authors demonstrated that inhibition of tyrosine phosphatase SHP-1 in leukemia stem cells increased their glycolysis and oxidative phosphorylation, enhancing their sensitivity to chemotherapy and vulnerability to immunosurveillance.
    [Nature Cell Biology]


    USP22 Supports the Aggressive Behavior of Basal-Like Breast Cancer by Stimulating Cellular Respiration

    Researchers utilized the MMTV-cre, The Ubiquitin Specific Peptidase 22 (Usp22)fl/fl transgenic mouse model to study the involvement of USP22 in the stem cell-like properties of the growing mammary tissue.
    [Cell Communication And Signaling]

    Full Article

    Selective Expansion of Renal Cancer Stem Cells Using Microfluidic Single-Cell Culture Arrays for Anticancer Drug Testing

    Scientists employed microfluidic single-cell culture arrays to expand renal cancer stem cells by exploiting the anti-apoptosis and self-renewal properties of tumor stem cells.
    [Lab On A Chip]

    AbstractGraphical Abstract

    Bimetallic Gold/Silver and Bioactive Camptothecin Hybrid Nanoparticles for Eradication of Cancer Stem Cells in a Combination Manner

    Gold/silver alloy nanoparticle decorated camptothecin nanocrystals were formulated according to complementary anti-CSC mechanisms from gold, silver, and organic drug.
    [Molecular Pharmaceutics]

    AbstractGraphical Abstract

    MUC1-EGFR Crosstalk with IL-6 by Activating NF-κB and MAPK Pathways to Regulate the Stemness and Paclitaxel-Resistance of Lung Adenocarcinoma

    The bioinformatics method was used to analyze the mRNA and protein expression characteristics of MUC1 in lung adenocarcinoma (LUAD).
    [Annals of Medicine]

    Full Article

    Helicobacter pylori CagA Protein Induces Gastric Cancer Stem Cell-Like Properties through the Akt/FOXO3a Axis

    Researchers revealed that CagA-positive gastric cancer cells infected with H. pylori exhibited CSC-like properties, such as heightened expression of CD44, a specific surface marker for CSCs, and increased ability to form tumor spheroids.
    [Journal of Cellular Biochemistry]


    LncRNA WWTR1-AS1 Upregulates Notch3 through miR-136 to Increase Cancer Cell Stemness in Cervical Squamous Cell Carcinoma

    WWTR1-AS1 expression was upregulated in cervical squamous cell carcinoma (CSCC) tissues. WWTR1-AS1 was predicted to interact with miR-136, whereas correlation analysis revealed that there was no close correlation between WWTR1-AS1 and miR-136 across CSCC samples.
    [BMC Womens Health]

    Full Article
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    Cancer Cell Plasticity: From Cellular, Molecular, and Genetic Mechanisms to Tumor Heterogeneity and Drug Resistance

    The authors explore the intricate landscape of cancer cell plasticity, offering a deep dive into the cellular, molecular, and genetic mechanisms that underlie this phenomenon.
    [Cancer and Metastasis Reviews]

    Full Article

    New Blood Test in Cancer Research Can Save Lives

    UWinnipeg graduate student Hailey Langford is working with Dr. Anuraag Shrivastav, who is committed to changing these grim statistics. Dr. Shrivastav’s research could reduce the mortality rate by creating a new screening test to detect colorectal cancer earlier.
    [The University of Winnipeg]

    Press Release

    Gale and Ira Drukier Prize in Children’s Health Research Awarded to Pediatric Cancer Specialist at the Hospital for Sick Children (SickKids)

    Dr. Sumit Gupta, a physician-scientist whose research focuses on vulnerable subpopulations of children with cancer, has been awarded the eighth annual Gale and Ira Drukier Prize in Children’s Health Research.
    [Weill Cornell Medicine]

    Press Release

    2024 Fibroblast Growth Factors in Development and Disease Conference GRC

    March 24 – 29, 2024
    Galveston, Texas, United States

    > See All Events


    Department Chair – Cell Biology and Human Anatomy

    UC Davis – Davis, California, United States

    Postdoctoral Scientists – Molecular Basis of Cancer

    Cyprus Cancer Research Institute – Aglandjia, Cyprus

    Research Assistant – Molecular Basis of Cancer

    Cyprus Cancer Research Institute – Aglandjia, Cyprus

    Senior Research Assistant – Leukemia

    University of Texas MD Anderson Cancer Center – Houston, Texas, United States

    Tenure-Track Faculty – Metabolic Sciences

    The Genomics Research Center, Academia Sinica – Taipei City, Taiwan

    > See All Jobs

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