Cancer Stem Cell News Volume 13.06 | Feb 21 2024

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    2024-02-21 | CSCN 13.06


    Cancer Stem Cell News by STEMCELL Technologies
    Vol. 13.06 – 21 February, 2024
    TOP STORY

    Methionine Secreted by Tumor-Associated Pericytes Supports Cancer Stem Cells in Clear Cell Renal Carcinoma

    Scientists identified a subset of vascular pericytes that promoted tumorigenesis and tyrosine kinase inhibitors resistance by functioning as the primary methionine source for CSCs in clear cell renal cell carcinoma.
    [Cell Metabolism]

    AbstractGraphical Abstract
    Tips to prepare for your next conference or networking event
    PUBLICATIONSRanked by the impact factor of the journal

    The Dopamine Transporter Antagonist Vanoxerine Inhibits G9a and Suppresses Cancer Stem Cell Functions in Colon Tumors

    Using a stem cell-based phenotypic drug-screening pipeline, the authors identified the dopamine transporter antagonist vanoxerine, a compound with previously demonstrated clinical safety, as a cancer-specific downregulator of G9a expression.
    [Nature Cancer]

    AbstractPress Release

    Aggresome Formation Promotes ASK1/JNK Signaling Activation and Stemness Maintenance in Ovarian Cancer

    The multiomics screening revealed that OTUD1 protein played an important role in retaining ovarian CSC properties. Mechanistically, the elevated OTUD1 protein levels led to the formation of OTUD1-based cytoplasmic aggresomes
    [Nature Communications]

    Full Article

    Cellular Hierarchy Insights Reveal Leukemic Stem-Like Cells and Early Death Risk in Acute Promyelocytic Leukemia

    Researchers unveiled a cellular differentiation hierarchy within acute promyelocytic leukemia blasts, rooted in leukemic stem-like cells.
    [Nature Communications]

    Full Article

    SALL4 Promotes Cancer Stem-Like Cell Phenotype and Radioresistance in Oral Squamous Cell Carcinomas via Methyltransferase-Like 3-Mediated m6A Modification

    The authors demonstrated that methyltransferase-like 3 was highly expressed in CD44(+) cells and promoted CSCs phenotype. Using RNA-sequencing analysis, they showed that Spalt-like transcription factor 4 (SALL4) was involved in the maintenance of CSCs properties.
    [Cell Death & Disease]

    Full Article

    FBP1 Inhibits NSCLC Stemness by Promoting Ubiquitination of Notch1 Intracellular Domain and Accelerating Degradation

    Scientists showed that overexpression of fructose-1,6-bisphosphatase 1 (FBP1), a gluconeogenic enzyme, functions as a tumor suppressor to regulate the stemness of NSC led to a decrease in the proportion of CD133-positive cells, weakened tumorigenicity, and decreased expression of stemness factors.
    [Cellular And Molecular Life Sciences]

    Full Article

    IL-24 Improves Efficacy of CAR-T Cell Therapy by Targeting Stemness of Tumor Cells

    The effect of CSCs on CAR-T cell therapy was determined using in vitro and in vivo assays. Subsequently, Interleukin-24 (IL-24) was expressed along with CAR in T cells.
    [British Journal Of Cancer]

    Abstract

    Discovery of Novel N-(Anthracen-9-ylmethyl) Benzamide Derivatives as ZNF207 Inhibitors Promising in Treating Glioma

    A series of novel N-(anthracen-9-ylmethyl) benzamide derivatives against ZNF207 were rationally designed and synthesized. The inhibitory activity was evaluated, and their structure–activity relationships were summarized.
    [Journal Of Medicinal Chemistry]

    AbstractGraphical Abstract

    Revealing Role of Epigenetic Modifiers and DNA Oxidation in Cell-Autonomous Regulation of Cancer Stem Cells

    Researchers used pharmacological inhibitor of H3K4, knockdown of KMT2B or KMT2D in breast cancer cells, real time PCR, response to chemotherapy, flow cytometry, and more for circulating markers of CSCs and DNA hydroxylases in breast cancer patients.
    [Cell Communication and Signaling]

    Full Article
    Survey results on the needs and challenges in the human pluripotent stem cell field
    REVIEWS

    Phenotypic Transitions the Processes Involved in Regulation of Growth and Proangiogenic Properties of Stem Cells, Cancer Stem Cells, and Circulating Tumor Cells

    Circulating tumor cells exhibit molecular diversity and stem-like and mesenchymal features, even when derived from primary tumor tissue from a single patient.
    [Stem Cell Reviews And Reports]

    Full Article
    INDUSTRY AND POLICY NEWS

    NIH Launches Research Network to Evaluate Emerging Cancer Screening Technologies

    The National Institutes of Health (NIH) has launched a clinical trials network to evaluate emerging technologies for cancer screening.
    [National Institutes of Health]

    Press Release

    Iovance’s AMTAGVI™ (lifileucel) Receives US FDA Accelerated Approval for Advanced Melanoma

    Iovance Biotherapeutics, Inc. announced that the US FDA has approved AMTAGVI suspension for intravenous infusion.
    [Iovance Biotherapeutics, Inc.]

    Press Release
    FEATURED EVENT

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    JOB OPPORTUNITIES

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    University of Southern California – Los Angeles, California, United States

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    UC Davis – Davis, California, United States

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    Cyprus Cancer Research Institute – Aglandjia, Cyprus

    Tenure-Track Faculty – Metabolic Sciences

    The Genomics Research Center, Academia Sinica – Taipei City, Taiwan

    Research Assistant – GI Medical Oncology Research Program

    University of Washington – Seattle, Washington, United States

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