Cancer Stem Cell News Volume 13.07 | Feb 28 2024

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    2024-02-28 | CSCN 13.07


    Cancer Stem Cell News by STEMCELL Technologies
    Vol. 13.07 – 28 February, 2024
    TOP STORY

    Single-Cell Transcriptomic Analysis Deciphers Heterogenous Cancer Stem-Like Cells in Colorectal Cancer and Their Organ-Specific Metastasis

    Investigators performed single-cell RNA sequencing and spatial transcriptomic analysis in primary colorectal cancer and metastases in the liver or ovary. They also conducted immunofluorescence staining and functional experiments to examine the mechanism.
    [Gut]

    Abstract
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    PUBLICATIONSRanked by the impact factor of the journal

    CD38-Directed, Single-Chain T Cell-Engager Targets Leukemia Stem Cells through IFNγ-Induced CD38 Expression

    Researchers investigated the correlation of immunity and cancer stemness with the molecular subtyping and survival rates in triple negative breast cancer using bioinformatics approaches.
    [Blood]

    Abstract

    Targeting PRMT9-Mediated Arginine Methylation Suppresses Cancer Stem Cell Maintenance and Elicits cGAS-Mediated Anticancer Immunity

    The authors showed that targeting protein arginine N-methyltransferase 9 (PRMT9), whose activities were elevated in blasts and leukemia stem cells from patients with acute myeloid leukemia, eliminated disease via cancer-intrinsic mechanisms and cancer-extrinsic type I interferon-associated immunity.
    [Nature Cancer]

    Full Article

    A Tumor Suppressor Protein Encoded by circKEAP1 Inhibits Osteosarcoma Cell Stemness and Metastasis by Promoting Vimentin Proteasome Degradation and Activating Anti-Tumor Immunity

    Microarray analysis was performed to identify circRNAs that were differentially-expressed between osteosarcoma and corresponding normal tissues.
    [Journal of Experimental & Clinical Cancer Research]

    Full Article

    LAPTM4B-Mediated Hepatocellular Carcinoma Stem Cell Proliferation and MDSC Migration: Implications for HCC Progression and Sensitivity to PD-L1 Monoclonal Antibody Therapy

    Scientists’ mechanistic investigations identified lysosomal-associated transmembrane protein 4B (LAPTM4B) as a crucial gene regulated by ETV1, especially in liver cancer stem cells.
    [Cell Death & Disease]

    Full Article

    CREB5 Promotes the Proliferation and Self-Renewal Ability of Glioma Stem Cells

    Both public dataset analysis and direct differentiation experiments on glioma stem cells demonstrated that cAMP response element-binding protein (CREB5) was more highly expressed in undifferentiated GSCs than in differentiated GSCs.
    [Cell Death Discovery]

    Full Article

    Identification of Subtypes in Triple-Negative Breast Cancer Based on Shared Genes Between Immunity and Cancer Stemness

    Researchers investigated the correlation of immunity and cancer stemness with the molecular subtyping and survival rates in triple negative breast cancer using bioinformatics approaches.
    [Journal Of Immunotherapy]

    Abstract

    USP14 Promotes the Cancer Stem-Like Cell Properties of OSCC via Promoting SOX2 Deubiquitination

    The authors identified new substrates of ubiquitin-specific-processing protease 14 (USP14) and elucidated their role in modulating cancer stem-like cells in oral squamous cell carcinoma. Bioinformatics prediction and docking were performed using UbiBrowser 2.0 and HDOCK, respectively.
    [Oral Diseases]

    Abstract

    Machine Learning Determines Stemness Associated with Simple and Basal-Like Canine Mammary Carcinomas

    The authors validated, using canine mammary tumor samples, a previously published canine one-class logistic regression machine learning algorithm to predict stemness in canine cancer cells.
    [Heliyon]

    Full Article
    March 2024 Science Events
    REVIEWS

    Cell Cycle Heterogeneity and Plasticity of Colorectal Cancer Stem Cells

    New evidence suggests that colorectal CSCs manifest substantial heterogeneity, as exemplified by the existence of both actively cycling Lgr5+ CSCs as well as quiescent Lgr5+ CSCs that are resistant to conventional anticancer therapies.
    [Cancer Science]

    Full Article

    Deciphering Cancer Cell State Plasticity with Single-Cell Genomics and Artificial Intelligence

    The advent of single-cell assays means these features can now be measured for individual cancer cells and at scale.
    [Genome Medicine]

    Full Article

    Cancer Stem Cell Hypothesis 2.0 in Glioblastoma: Where Are We Now and Where Are We Going?

    Scientists provide a historical perspective on the CSC hypothesis and its recent evolution, with a focus on key functional phenotypes, and provide an update on the definition for its use in future genomic studies.
    [Neuro-Oncology]

    Abstract
    INDUSTRY AND POLICY NEWS

    Cancer Experts Call on Philanthropists to Help Fund ‘Golden Age’ of Research

    Leading cancer experts from around the world are calling on wealthy individuals and philanthropists to dig into their deep pockets to accelerate a new golden age of cancer research.
    [Editorial]

    Full Article

    BC Cancer Researchers Recognized with 2023 Canadian Cancer Society Challenge Grants

    Congratulations to the BC Cancer researchers who are recipients of the 2023 Canadian Cancer Society Challenge Grants Competition. The grants provided through the competition support cancer research projects across the cancer continuum and across disciplines.
    [BC Cancer Research]

    Press Release
    FEATURED EVENT

    AACR Annual Meeting 2024

    April 7 – 10, 2024
    San Diego, California, United States

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Fellow – Stem Cell, Gene Editing, and Leukemia

    Albert Einstein College of Medicine – Bronx, New York, United States

    Research Assistant I – Prostate Cancer Genomics

    The Henry M. Jackson Foundation – Bethesda, Maryland, United States

    Research Associate – Breast Cancer and Brain Tumors

    Cedars Sinai Medical Center – Los Angeles, California, United States

    Internship Position – Leukemia Research

    Luxembourg Institute of Health – Strassen, Luxembourg

    Postdoctoral Research Associate – Neuro-Oncology

    University of Southern California – Los Angeles, California, United States

    > See All Jobs

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