 | | Vol. 13.07 – 28 February, 2024 |
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| Investigators performed single-cell RNA sequencing and spatial transcriptomic analysis in primary colorectal cancer and metastases in the liver or ovary. They also conducted immunofluorescence staining and functional experiments to examine the mechanism.
[Gut] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers investigated the correlation of immunity and cancer stemness with the molecular subtyping and survival rates in triple negative breast cancer using bioinformatics approaches.
[Blood] |
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| The authors showed that targeting protein arginine N-methyltransferase 9 (PRMT9), whose activities were elevated in blasts and leukemia stem cells from patients with acute myeloid leukemia, eliminated disease via cancer-intrinsic mechanisms and cancer-extrinsic type I interferon-associated immunity.
[Nature Cancer] |
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| Microarray analysis was performed to identify circRNAs that were differentially-expressed between osteosarcoma and corresponding normal tissues.
[Journal of Experimental & Clinical Cancer Research] |
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| Scientists’ mechanistic investigations identified lysosomal-associated transmembrane protein 4B (LAPTM4B) as a crucial gene regulated by ETV1, especially in liver cancer stem cells.
[Cell Death & Disease] |
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| Both public dataset analysis and direct differentiation experiments on glioma stem cells demonstrated that cAMP response element-binding protein (CREB5) was more highly expressed in undifferentiated GSCs than in differentiated GSCs.
[Cell Death Discovery] |
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| Researchers investigated the correlation of immunity and cancer stemness with the molecular subtyping and survival rates in triple negative breast cancer using bioinformatics approaches.
[Journal Of Immunotherapy] |
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| The authors identified new substrates of ubiquitin-specific-processing protease 14 (USP14) and elucidated their role in modulating cancer stem-like cells in oral squamous cell carcinoma. Bioinformatics prediction and docking were performed using UbiBrowser 2.0 and HDOCK, respectively.
[Oral Diseases] |
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| The authors validated, using canine mammary tumor samples, a previously published canine one-class logistic regression machine learning algorithm to predict stemness in canine cancer cells.
[Heliyon] |
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| New evidence suggests that colorectal CSCs manifest substantial heterogeneity, as exemplified by the existence of both actively cycling Lgr5+ CSCs as well as quiescent Lgr5+ CSCs that are resistant to conventional anticancer therapies.
[Cancer Science] |
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| The advent of single-cell assays means these features can now be measured for individual cancer cells and at scale.
[Genome Medicine] |
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| Scientists provide a historical perspective on the CSC hypothesis and its recent evolution, with a focus on key functional phenotypes, and provide an update on the definition for its use in future genomic studies.
[Neuro-Oncology] |
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| Leading cancer experts from around the world are calling on wealthy individuals and philanthropists to dig into their deep pockets to accelerate a new golden age of cancer research.
[Editorial] |
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| Congratulations to the BC Cancer researchers who are recipients of the 2023 Canadian Cancer Society Challenge Grants Competition. The grants provided through the competition support cancer research projects across the cancer continuum and across disciplines.
[BC Cancer Research] |
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| April 7 – 10, 2024
San Diego, California, United States |
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| | Albert Einstein College of Medicine – Bronx, New York, United States |
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| | The Henry M. Jackson Foundation – Bethesda, Maryland, United States |
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| | Cedars Sinai Medical Center – Los Angeles, California, United States |
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| | Luxembourg Institute of Health – Strassen, Luxembourg |
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| | University of Southern California – Los Angeles, California, United States |
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