 | | Vol. 13.08 – 6 March, 2024 |
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| Scientists revealed that mitochondrial folate metabolism was upregulated in patient-derived leukemic stem cells. They demonstrated that inhibition of mitochondrial one carbon metabolism through impairment of de novo purine synthesis has a cytostatic effect on chronic myeloid leukemia cells.
[Nature Communications] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers investigated the roles of cold‑inducible RNA binding protein in regulating hyperthermia resistance and underlying mechanisms in nasopharyngeal carcinoma.
[Journal Of Experimental & Clinical Cancer Research] |
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| Mechanistically, inhibition of DNAJC10 specifically induced endoplasmic reticulum stress and promoted activation of protein kinase RNA-like ER kinase (PERK)-eukaryotic initiation factor 2 α subunit-activating transcription factor 4 branch of unfolded protein response.
[Haematologica] |
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| Investigators treated pancreatic tumor organoids with 4 or 8 Gy of radiation, 10 μM of 5-Fluorouracil, and 100 μM 3-Bromopyruvate, a promising anti-cancer drug, as a single treatment modalities, and in combination with RT.
[Cell Death Discovery] |
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| Scientists found that lactate increased CSC characteristics of head and neck squamous cell carcinoma by influencing the deposition of type I collagen (Col I). Lactate promoted Col I deposition through two distinct pathways.
[iScience] |
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| Researchers proposed a model for examining circulating miRNAs as diagnostic and predictive markers for HCC in Egyptian patients and their clinical and pathological characteristics.
[Scientific Reports] |
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| Nine circulating tumor DNA assays, including one benchmark assay, were evaluated using 23 contrived reference samples. There were two sample types, three circulating tumor DNA inputs, two variant allele frequency ranges, and four variant types.
[Scientific Reports] |
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| Investigators employed the single sample gene set enrichment analysis algorithm to evaluate the stemness of samples in combined datasets. Samples were then classified into high and low stemness subgroups based on their average stemness scores.
[Heliyon] |
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| The authors characterized the expression and function of GTP binding protein 2 (GTPBP2) in a chemical-induced mouse colorectal cancer (CRC) model. They found that GTPBP2 was expressed at a higher level in CD133+CD44+ CCSCs compared with other CRC cells.
[Heliyon] |
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| Scientists summarize the targeting of CSCs by various immunotherapy strategies such as monoclonal antibodies, tumor vaccines, immune checkpoint inhibitors, and chimeric antigen receptor-T cells in pre-clinical and clinical studies.
[Critical Reviews In Oncology/Hematology] |
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| MAIA Biotechnology, Inc., announced positive efficacy data for third-line treatment in its Phase II THIO-101 clinical trial evaluating THIO sequenced with the immune checkpoint inhibitor cemiplimab in advanced non-small cell lung cancer.
[MAIA Biotechnology, Inc.] |
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| Innate Pharma SA announced the first patient was dosed in its Phase I/II multicenter trial, investigating the safety and tolerability of IPH6501 in patients with relapsed and/or refractory CD20-expressing B cell non-Hodgkin’s Lymphoma.
[Innate Pharma SA] |
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| April 22 – 25, 2024
Baltimore, Maryland, United States |
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| | Foundation for Liver Research – London, England, United Kingdom |
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| | University Medical Center Groningen – Groningen, Netherlands |
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| | Georg-Speyer-Haus – Frankfurt, Germany |
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| | Montreal Clinical Research Institute РMontr̩al, Qu̩bec, Canada |
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| | St. Jude Children’s Research Hospital – Memphis, Tennessee, United States |
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