Cancer Stem Cell News Volume 13.09 | Mar 20 2024

    0
    69








    2024-03-20 | CSCN 13.09


    Cancer Stem Cell News by STEMCELL Technologies
    Vol. 13.09 – 20 March, 2024
    TOP STORY

    Epigenetic Control Over Cell-Intrinsic Immune Response Antagonizes Self-Renewal in Acute Myeloid Leukemia

    Site-specific phosphorylation of PHF8 orchestrated epigenetic changes that upregulate cytosolic RNA sensors, particularly the TRIM25-RIG-I-IFIT5 axis, thereby triggering the cellular IFN-I response-differentiation-apoptosis network.
    [Blood]

    Abstract
    PUBLICATIONSRanked by the impact factor of the journal

    Bio-Responsive Au-miR-183 Inhibitor Enhances Immunotherapy in Hepatocellular Carcinoma by Inducing Immunogenic Cell Death

    Scientists constructed a bio-responsive Au-miR-183 inhibitor delivery system targeting liver CSCs, and adopted the strategy of combining αPD-L1 immunotherapy.
    [Journal Of Controlled Release]

    Full Article

    Hypoxia-Induced TREM1 Promotes Mesenchymal-Like States of Glioma Stem Cells via Alternatively Activating Tumor-Associated Macrophages

    Investigators showed that the triggering receptor expressed on myeloid cells-1 (TREM1) preferentially expressed by M2-like tumor-associated macrophages and induced glioma stem cells into mesenchymal-like states by modulating the secretion of TGFβ2.
    [Cancer Letters]

    Full Article

    Inhibition of the AURKA/YAP1 Axis Is a Promising Therapeutic Option for Overcoming Cetuximab Resistance in Colorectal Cancer Stem Cells

    The authors used transcriptomic analysis along with in vitro and in vivo models of RAS/RAF wild-type CRC to study YAP1 Ser397 phosphorylation as a potential biomarker for cetuximab resistance.
    [British Journal Of Cancer]

    Full Article

    Selective Expansion of Renal Cancer Stem Cells Using Microfluidic Single-Cell Culture Arrays for Anticancer Drug Testing

    Scientists employed microfluidic single-cell culture arrays to expand renal cancer stem cells by exploiting the anti-apoptosis and self-renewal properties of tumor stem cells.
    [Lab On A Chip]

    AbstractGraphical Abstract

    Targeting Metastasis-Initiating Cancer Stem Cells in Gastric Cancer with Leukemia Inhibitory Factor

    Leukemia inhibitory factor-treated gastric cancer cell lines, patient-derived xenograft cells and/or CSC tumourspheres underwent transcriptomics, laser microdissection-associated proteomics, 2D and 3D invasion assays and in vivo xenograft in mice blood circulation.
    [Cell Death Discovery]

    Full Article

    SOX2 and OCT4 Mediate Radiation and Drug Resistance in Pancreatic Tumor Organoids

    Investigators treated pancreatic tumor organoids with 4 or 8 Gy of radiation, 10 μM of 5-Fluorouracil, and 100 μM 3-Bromopyruvate, a promising anti-cancer drug, as a single treatment modalities, and in combination with RT.
    [Cell Death Discovery]

    Full Article

    An Immunogenic Anti-Cancer Stem Cell Bi-Nuclear Copper(II)-Flufenamic Acid Complex

    The bi-nuclear copper(II) complex exhibited sub-micromolar potency towards breast CSCs grown in monolayers and three-dimensional cultures.
    [Dalton Transactions]

    Full ArticlePress Release

    Butyrate Attenuates the Stemness of Lung Cancer Cells through Lysosome Fe2+– and SLC7A11-Mediated Ferroptosis

    The authors constructed a series of in vitro experiments, including 3D non-adherent sphere-formation, cytometry analysis, assessment of CSC marker expression, cell migration assay, and in vivo tumorigenesis analyses.
    [Heliyon]

    Full Article
    Learn about key considerations for using EasySep™ products and tips & tricks to avoid the most commonly made mistakes.
    REVIEWS

    The Present and Future of Bispecific Antibodies for Cancer Therapy

    Investigators provide an outlook into next-generation bispecific antibodies (bsAbs) in earlier stages of development, including trispecifics, bsAb prodrugs, bsAbs that induce degradation of tumour targets and bsAbs acting as cytokine mimetics.
    [Nature Reviews Drug Discovery]

    Abstract

    Ferroptosis in Cancer: From Molecular Mechanisms to Therapeutic Strategies

    Scientists provide an overview of the recent advancements in understanding ferroptosis in cancer, covering molecular mechanisms, biological functions, regulatory pathways, and interactions with the tumor microenvironment.
    [Signal Transduction And Targeted Therapy]

    Full Article
    INDUSTRY AND POLICY NEWS

    Cancer Association Recognizes Owen Witte for Advancing Blood Cancer Research

    The American Association for Cancer Research has awarded Dr. Owen Witte, founding director emeritus of the UCLA Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, with the 2024 Award for Outstanding Achievement in Blood Cancer Research.
    [UCLA]

    Press Release

    $1.25 Million Prostate Cancer Research Grant

    Prostate cancer research team including Drs. Roseline Godbout, Adam Kinnaird, and Ron Moore have been awarded a $1.25 million, four-year Alberta Cancer Foundation “Game Changer Grant” to investigate the link between fat metabolism and prostate cancer progression.
    [University of Alberta]

    Press Release
    FEATURED EVENT

    Microsymposium on RNA Biology

    April 24 – 26, 2024
    Vienna, Austria

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Fellow – Cancer Bioinformatics

    Universitätsklinikum Köln – Cologne, Germany

    Senior Researcher – Hematopoietic Stem Cell Biology and Leukemia

    Francis Crick Institute – London, England, United Kingdom

    PhD Student – Intestinal Tumorigenesis

    University of Montpellier – Montpellier, France

    Postdoctoral Scientist – Cancer Immunology and ECMs

    Foundation for Liver Research – London, England, United Kingdom

    PhD Position – Translational Immune-Oncology in Blood Cancers

    Georg-Speyer-Haus – Frankfurt, Germany

    > See All Jobs

    Submit an article, publication, job or event
    Brought to you by
    stemcell-logo-for newsletter-2