Cancer Stem Cell News Volume 13.10 | Apr 3 2024

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    2024-04-03 | CSCN 13.10


    Cancer Stem Cell News by STEMCELL Technologies
    Vol. 13.10 – 3 April, 2024
    TOP STORY

    LINC00115 Promotes Chemoresistant Breast Cancer Stem-Like Cell Stemness and Metastasis through SETDB1/PLK3/HIF1α Signaling

    LncRNA microarray assay was performed to document abundance changes of lncRNAs in paclitaxel resistant MDA-MB-231 breast cancer stem-like cell (BCSC) and non-BCSC. RNA pull-down and RNA immunoprecipitation assays were performed to determine the binding proteins of LINC00115.
    [Molecular Cancer]

    Full Article
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    PUBLICATIONSRanked by the impact factor of the journal

    Single-Cell and Spatial Analyses Revealed the Co-Location of Cancer Stem Cells and SPP1+ Macrophage in Hypoxic Region that Determines the Poor Prognosis in Hepatocellular Carcinoma

    The authors undertook a comprehensive study combining single-cell data and spatial data to obtain CSC signature and uncover its spatial structure.
    [NPJ Precision Oncology]

    Full Article

    DMRTA2 Supports Glioma Stem-Cell Mediated Neovascularization in Glioblastoma

    Investigators showed the upregulation of doublesex- and mab-3–related transcription factor a2 (DMRTA2) expression in malignant gliomas. Immunohistochemical staining showed the protein concentrated in small cells with high proliferative potential and cells localized around blood vessels, where it colocalized with pericyte-specific markers.
    [Cell Death & Disease]

    Full Article

    Chronic Hypoxia Remodels the Tumor Microenvironment to Support Glioma Stem Cell Growth

    Researchers describe long-term cerebral organoids (COs) co-cultured with patient derived glioma stem cells (GSCs), a novel model in which COs were grown from embryonic stem cell cultures containing low levels of GSCs and tumor development wasmonitored over extended durations
    [Acta Neuropathologica Communications]

    Full Article

    Coordinated Activation of DNMT3a and TET2 in Cancer Stem Cell-Like Cells Initiates and Sustains Drug Resistance in Hepatocellular Carcinoma

    Scientists addressed whether and how dysregulated epigenetic regulators have regulatory and functional communications in establishing and maintaining drug resistance.
    [Cancer Cell International]

    Full Article

    YTHDF1 Promotes the Viability and Self-Renewal of Glioma Stem Cells by Enhancing LINC00900 Stability

    Researchers investigated the molecular mechanism underlying the regulatory effects of YTHDF1 on the viability, invasion and self‑renewal of glioma stem cells.
    [International Journal Of Oncology]

    Abstract

    Hypoxia Drives Shared and Distinct Transcriptomic Changes in Two Invasive Glioma Stem Cell Lines

    Investigators surveyed eight patient-derived glioblastoma (GBM) stem cell lines for invasion phenotypes in 3D culture, which identified two GBM lines showing increased invasiveness in response to hypoxia.
    [Scientific Reports]

    Full Article

    Involvement of TGFBI-TAGLN Axis in Cancer Stem Cell Property of Head and Neck Squamous Cell Carcinoma

    Through RNA-sequencing data from the TCGA database, scientists validated that increased TGFBI expression correlated with a higher occurrence of lymph node metastasis and unfavorable prognosis in head and neck squamous cell carcinoma cases.
    [Scientific Reports]

    Full Article

    Uracil- and Pyridine-Containing HDAC Inhibitors Displayed Cytotoxicity in Colorectal and Glioblastoma Cancer Stem Cells

    Seven HDACi, showing either hydroxamate or 2′-aminoanilide function, were tested in colorectal cancer and glioblastoma multiforme CSCs to determine their effects on cell proliferation, H3 acetylation levels and in-cell HDAC activity.
    [ChemMedChem]

    Abstract
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    REVIEWS

    Exploiting Transcription Factors to Target EMT and Cancer Stem Cells for Tumor Modulation and Therapy

    Understanding how transcription factors interact with their downstream targets for determining cell fate during embryogenesis and tumor development is a critical area of research.
    [Seminars In Cancer Biology]

    Abstract

    Glioblastoma Stem Cell Metabolism and Immunity

    The mechanisms by which glioma stem cells (GSCs) alter metabolic cues and escape elimination by immune cells are discussed, along with potential strategies to harness effector immune cells against GSCs.
    [Cancer And Metastasis Reviews]

    Abstract
    INDUSTRY AND POLICY NEWS

    Datopotamab Deruxtecan Biologics License Application Accepted in the US for Patients with Previously Treated Metastatic HR-Positive, HER2-Negative Breast Cancer

    AstraZeneca and Daiichi Sankyo’s Biologics License Application for datopotamab deruxtecan has been accepted in the US for the treatment of adult patients with unresectable or metastatic hormone receptor-positive, HER2-negative breast cancer who have received prior systemic therapy.
    [AstraZeneca]

    Press Release

    Syndax Announces FDA Priority Review of NDA for Revumenib for the Treatment of Relapsed/Refractory KMT2Ar Acute Leukemia

    Syndax Pharmaceuticals announced that the US FDA has granted Priority Review for its New Drug Application (NDA) for revumenib for the treatment of adult and pediatric relapsed or refractory KMT2A-rearranged acute leukemia.
    [Syndax Pharmaceuticals]

    Press Release
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    JOB OPPORTUNITIES

    Postdoctoral Position – Pancreatic Cancer Research

    Umeå University – Umeå, Sweden

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    Universitätsklinikum Köln – Cologne, Germany

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    Francis Crick Institute – London, England, United Kingdom

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    University of Montpellier – Montpellier, France

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    Foundation for Liver Research – London, England, United Kingdom

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