 | | Vol. 13.11 – 17 April, 2024 |
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| Scientists unequivocally identified a subpopulation of circulating tumor cells (CTCs) shielded with extracellular vesicle-derived CD45 that resisted T cell attack. A higher percentage of CD45+ CTCs was found to be closely correlated with a higher incidence of metastasis and worse prognosis in cancer patients.
[Signal Transduction And Targeted Therapy] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers defined GADD45A as a key downstream target of LGR4 oncogenic signaling and discovered a regulatory role for GADD45A loss in promoting leukemia-initiating activity and oxidative resistance in LGR4/HOXA9-dependent AML, a poor prognosis subset of leukemia.
[Blood] |
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| The authors identified that IFI35, a transcriptional regulatory factor, played both cell-intrinsic and cell-extrinsic roles in maintaining glioma stem cells and the immunosuppressive tumor microenviroment.
[Cell Death & Differentiation] |
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| Scientists shed light on the bidirectional crosstalk between liver CSCs and immune cells for liver cancer progression, as well as the underlying molecular mechanisms after presenting an overview of liver CSCs characteristic and their microenvironment.
[Frontiers Of Medicine] |
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| To identify novel therapeutic approaches, researchers performed CRISPR/Cas9 knockout screens and discovered TGFβ activated kinase (TAK1) as a selective survival factor in a significant fraction of glioma stem cells.
[Cell Death & Disease] |
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| Scientists elucidated the underlying mechanism involving the DNMT1/miR-152-3p/SOS1 axis in regulating the self-renewal and tumor growth of lung cancer stem-like cells.
[Clinical Epigenetics] |
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| Researchers used a multistep in silico screening strategy to identify repurposed candidate drugs against selected therapeutic molecular targets in glioblastoma with potential to concomitantly target glioblastoma stem cells.
[Molecular Neurobiology] |
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| The authors investigated the potential roles of mesothelin (MSLN) in chemoresistance and its relationship with proliferation, epithelial-mesenchymal transition, and cancer stemness of pancreatic cancer cells.
[Heliyon] |
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| Researchers elucidated angiocrine factors related to CSC maintenance, focusing on Secreted frizzled-related protein 1 (Sfrp1). Although Sfrp1 is a Wnt pathway-related factor, its impact on tumor tissues remains unknown.
[In Vitro Cellular & Developmental Biology – Animal] |
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| Investigators comprehensively review the traditional aspects of transcriptional regulation, and explore the progress and insights of the impact on CSC transcription and status through tumor microenvironment, hypoxia, metabolism and new meaningful regulatory factors in conjunction with the latest research.
[Journal Of Experimental & Clinical Cancer Research] |
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| The authors review how state-of-the-art multiomics applied to circulating tumor cells (CTCs) are shedding light on how cancer spreads. They highlight the potential implications of CTC profiling for clinical applications aimed at enhancing cancer diagnosis and treatment.
[Academic Pediatrics] |
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| Evaxion Biotech A/S announced that the first patient in its EVX-01 Phase II trial in metastatic melanoma received the last vaccine dose in combination with KEYTRUDA®. The study assessed the efficacy, safety, and ability to induce a tumor-specific immune response of the EVX-01 cancer vaccine.
[Evaxion Biotech A/S (Globe Newswire)] |
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| May 6 – 9, 2024
Killarney, Ireland |
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| | City of Hope – Duarte, California, United States |
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| | Cold Spring Harbor Laboratory – Cold Spring Harbor, New York, United States |
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| | University of Michigan – Ann Arbor, Michigan, United States |
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| | Trieste University – Trieste, Italy |
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| | Georg-Speyer-Haus – Frankfurt, Germany |
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