Cancer Stem Cell News Volume 13.11 | Apr 17 2024


    2024-04-17 | CSCN 13.11

    Cancer Stem Cell News by STEMCELL Technologies
    Vol. 13.11 – 17 April, 2024

    Circulating Tumor Cells Shielded with Extracellular Vesicle-Derived CD45 Evade T Cell Attack to Enable Metastasis

    Scientists unequivocally identified a subpopulation of circulating tumor cells (CTCs) shielded with extracellular vesicle-derived CD45 that resisted T cell attack. A higher percentage of CD45+ CTCs was found to be closely correlated with a higher incidence of metastasis and worse prognosis in cancer patients.
    [Signal Transduction And Targeted Therapy]

    Full Article
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    Loss of Stress Sensor GADD45A Promotes Stem Cell Activity and Ferroptosis Resistance in LGR4/HOXA9-Dependent AML

    Researchers defined GADD45A as a key downstream target of LGR4 oncogenic signaling and discovered a regulatory role for GADD45A loss in promoting leukemia-initiating activity and oxidative resistance in LGR4/HOXA9-dependent AML, a poor prognosis subset of leukemia.


    IFI35 Regulates Non-Canonical NF-κB Signaling to Maintain Glioblastoma Stem Cells and Recruit Tumor-Associated Macrophages

    The authors identified that IFI35, a transcriptional regulatory factor, played both cell-intrinsic and cell-extrinsic roles in maintaining glioma stem cells and the immunosuppressive tumor microenviroment.
    [Cell Death & Differentiation]


    Cancer Stem Cell-Immune Cell Crosstalk in the Tumor Microenvironment for Liver Cancer Progression

    Scientists shed light on the bidirectional crosstalk between liver CSCs and immune cells for liver cancer progression, as well as the underlying molecular mechanisms after presenting an overview of liver CSCs characteristic and their microenvironment.
    [Frontiers Of Medicine]


    TAK1 Inhibition Leads to RIPK1-Dependent Apoptosis in Immune-Activated Cancers

    To identify novel therapeutic approaches, researchers performed CRISPR/Cas9 knockout screens and discovered TGFβ activated kinase (TAK1) as a selective survival factor in a significant fraction of glioma stem cells.
    [Cell Death & Disease]

    Full Article

    DNMT1/miR-152-3p/SOS1 Signaling Axis Promotes Self-Renewal and Tumor Growth of Cancer Stem-Like Cells Derived from Non-Small Cell Lung Cancer

    Scientists elucidated the underlying mechanism involving the DNMT1/miR-152-3p/SOS1 axis in regulating the self-renewal and tumor growth of lung cancer stem-like cells.
    [Clinical Epigenetics]

    Full Article

    A Multistep In Silico Approach Identifies Potential Glioblastoma Drug Candidates via Inclusive Molecular Targeting of Glioblastoma Stem Cells

    Researchers used a multistep in silico screening strategy to identify repurposed candidate drugs against selected therapeutic molecular targets in glioblastoma with potential to concomitantly target glioblastoma stem cells.
    [Molecular Neurobiology]


    MSLN Induced EMT, Cancer Stem Cell Traits, and Chemotherapy Resistance of Pancreatic Cancer Cells

    The authors investigated the potential roles of mesothelin (MSLN) in chemoresistance and its relationship with proliferation, epithelial-mesenchymal transition, and cancer stemness of pancreatic cancer cells.

    Full ArticleGraphical Abstract

    Tumor Endothelial Cell-Derived Sfrp1 Supports the Maintenance of Cancer Stem Cells via Wnt Signaling

    Researchers elucidated angiocrine factors related to CSC maintenance, focusing on Secreted frizzled-related protein 1 (Sfrp1). Although Sfrp1 is a Wnt pathway-related factor, its impact on tumor tissues remains unknown.
    [In Vitro Cellular & Developmental Biology – Animal]

    Full Article
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    Transcriptional Regulation of Cancer Stem Cell: Regulatory Factors Elucidation and Cancer Treatment Strategies

    Investigators comprehensively review the traditional aspects of transcriptional regulation, and explore the progress and insights of the impact on CSC transcription and status through tumor microenvironment, hypoxia, metabolism and new meaningful regulatory factors in conjunction with the latest research.
    [Journal Of Experimental & Clinical Cancer Research]

    Full Article

    A Molecular Voyage: Multiomics Insights Into Circulating Tumor Cells

    The authors review how state-of-the-art multiomics applied to circulating tumor cells (CTCs) are shedding light on how cancer spreads. They highlight the potential implications of CTC profiling for clinical applications aimed at enhancing cancer diagnosis and treatment.
    [Academic Pediatrics]


    Evaxion Announces Phase II Clinical Trial Update: First Patient Completed Dosing with Personalized Cancer Vaccine EVX-01

    Evaxion Biotech A/S announced that the first patient in its EVX-01 Phase II trial in metastatic melanoma received the last vaccine dose in combination with KEYTRUDA®. The study assessed the efficacy, safety, and ability to induce a tumor-specific immune response of the EVX-01 cancer vaccine.
    [Evaxion Biotech A/S (Globe Newswire)]

    Press Release

    Myeloid Targeting Strategies for Cancer Treatment

    May 6 – 9, 2024
    Killarney, Ireland

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    Postdoctoral Fellow – Stem Cell Cancer Research

    City of Hope – Duarte, California, United States

    Postdoctoral Fellow – Host-Immune Cell Interactions

    Cold Spring Harbor Laboratory – Cold Spring Harbor, New York, United States

    Research Fellow – Brain Tumors

    University of Michigan – Ann Arbor, Michigan, United States

    Postdoctoral Position – Cancer Cell Signaling and Mechanobiology

    Trieste University – Trieste, Italy

    PhD Position – Translational Immune-Oncology in Blood Cancers

    Georg-Speyer-Haus – Frankfurt, Germany

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