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Vol. 13.13 – 15 May, 2024
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Using a combination of transcriptomic, proteomic, and phosphoproteomic analyses, longitudinal imaging, and other assays, investigators demonstrated that chemoradiation and brain vasculature induce cell transition to a functional state named vessel co-opting and resistant cell state.
[Nature Communications]
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PUBLICATIONSRanked by the impact factor of the journal
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SMYD2-induced PGC1α methylation and followed nuclear export was confirmed by co-immunoprecipitation, cellular fractionation, and immunofluorescence.
[Neuro-Oncology]
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Researchers designed a bispecific T cell engager capable of cross-linking CD3 on T cells with NKG2DL-expressing GBM cells. They then engineered the G207 virus to express the NKG2D BiTE and secrete it from infected cells.
[Journal For Immunotherapy Of Cancer]
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The authors generated GPC3-targeted CAR-T cells overexpressing GLUT1 or AGK for the treatment of HCC. GPC3-targeted CAR-T cells overexpressing GLUT1 or AGK specifically and effectively lysed GPC3-positive tumor cells in vitro in an antigen-dependent manner.
[Acta Pharmacologica Sinica]
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In vitro and in vivo experiments confirmed that overexpression of Circ-0075305 could effectively reduce stem cell-like properties and enhanced the sensitivity of gastric cancer cells to Oxaliplatin compared with the control group.
[Communications Biology]
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The authors showed that CD271 mRNA, but not CD271 protein, facilitated spheroid cell proliferation. They established CD271−/− cells lacking both mRNA and protein of CD271, as well as CD271 protein knockout cells lacking only CD271 protein, from hypopharyngeal and oral squamous cell carcinoma lines.
[Cancer Science]
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Researchers reported that TRIM58 was underexpressed in TNBC tissues and cells compared to adjacent mucosa tissue, and its downregulation was significantly associated with shorter survival.
[Cancer Gene Therapy]
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Investigators isolated exosomes (Exos) from MSCs, and using probe-sonication approach loaded them with vincristine (VCR) sulfate. Using SRB assay, the cytotoxicity of VCR sulfate-Exo was assessed in T47D breast cancer cells, and the results were contrasted with those of free VCR sulfate.
[Scientific Reports]
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Bladder cancer cells were used to investigate the effects of Nup93 overexpression or knockdown on cell growth, invasion, stemness , and Wnt/β-catenin signaling in vitro.
[Molecular Biotechnology]
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Scientists discuss the state of the art of CSC biology and their potential exploitation as therapeutic target in uveal melanoma.
[Biochimica Et Biophysica Acta-Reviews On Cancer]
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Scientists discuss next-generation sequencing workflows, the structure of next-generation sequencing reports, and our recommendations for best practice thereof.
[British Journal Of Cancer]
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Investigators explore recent advances in iron metabolism in CSCs, conventional cancer therapies targeting iron biochemistry, therapeutic resistance in these cells, and potential treatment options that could overcome them.
[Cancer Cell International]
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Intensity Therapeutics, Inc. announced that they executed a collaboration agreement with The Swiss Group for Clinical Cancer Research SAKK to conduct a Phase II randomized, controlled trial evaluating clinical and biological effects of intratumoral INT230-6 in early-stage triple-negative breast cancer.
[Intensity Therapeutics, Inc.]
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Researchers at Washington University School of Medicine in St. Louis have received a $5 million grant from the Leukemia & Lymphoma Society to support research aimed at developing new immunotherapies for different types of blood-based cancers.
[Washington University School of Medicine in St. Louis]
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June 13 – 16, 2024
Madrid, Spain & Online
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The University of Texas MD Anderson Cancer Center – Houston, Texas, United States
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BC Cancer – Vancouver, British Columbia, Canada
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University of Copenhagen – Copenhagen, Denmark
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Case Western Reserve University – Cleveland, Ohio, United States
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Cedars-Sinai Medical Center – Los Angeles, California, United States
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Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News