Cancer Stem Cell News Volume 13.13 | May 15 2024

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    2024-05-15 | CSCN 13.13


    Cancer Stem Cell News by STEMCELL Technologies
    Vol. 13.13 – 15 May, 2024
    TOP STORY

    VC-Resist Glioblastoma Cell State: Vessel Co-Option as a Key Driver of Chemoradiation Resistance

    Using a combination of transcriptomic, proteomic, and phosphoproteomic analyses, longitudinal imaging, and other assays, investigators demonstrated that chemoradiation and brain vasculature induce cell transition to a functional state named vessel co-opting and resistant cell state.
    [Nature Communications]

    Full Article
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    SMYD2 Induced PGC1α Methylation Promotes Stemness Maintenance of Glioblastoma Stem Cells

    SMYD2-induced PGC1α methylation and followed nuclear export was confirmed by co-immunoprecipitation, cellular fractionation, and immunofluorescence.
    [Neuro-Oncology]

    AbstractGraphical Abstract

    Targeting NKG2D Ligands in Glioblastoma with a Bispecific T-Cell Engager Is Augmented with Conventional Therapy and Enhances Oncolytic Virotherapy of Glioma Stem-Like Cells

    Researchers designed a bispecific T cell engager capable of cross-linking CD3 on T cells with NKG2DL-expressing GBM cells. They then engineered the G207 virus to express the NKG2D BiTE and secrete it from infected cells.
    [Journal For Immunotherapy Of Cancer]

    Full Article

    GPC3-Targeted CAR-T Cells Expressing GLUT1 or AGK Exhibit Enhanced Antitumor Activity against Hepatocellular Carcinoma

    The authors generated GPC3-targeted CAR-T cells overexpressing GLUT1 or AGK for the treatment of HCC. GPC3-targeted CAR-T cells overexpressing GLUT1 or AGK specifically and effectively lysed GPC3-positive tumor cells in vitro in an antigen-dependent manner.
    [Acta Pharmacologica Sinica]

    Abstract

    Circ-0075305 Hinders Gastric Cancer Stem Cells by Indirectly Disrupting TCF4–β-Catenin Complex and Downregulation of SOX9

    In vitro and in vivo experiments confirmed that overexpression of Circ-0075305 could effectively reduce stem cell-like properties and enhanced the sensitivity of gastric cancer cells to Oxaliplatin compared with the control group.
    [Communications Biology]

    Full Article

    CD271 mRNA/hnRNPA2B1 Complex Promotes Proliferation and Stemness in Oral and Head and Neck Squamous Cell Carcinoma

    The authors showed that CD271 mRNA, but not CD271 protein, facilitated spheroid cell proliferation. They established CD271−/− cells lacking both mRNA and protein of CD271, as well as CD271 protein knockout cells lacking only CD271 protein, from hypopharyngeal and oral squamous cell carcinoma lines.
    [Cancer Science]

    Full Article

    TRIM58 Downregulation Maintains Stemness via MYH9-GRK3-YAP Axis Activation in Triple-Negative Breast Cancer Stem Cells

    Researchers reported that TRIM58 was underexpressed in TNBC tissues and cells compared to adjacent mucosa tissue, and its downregulation was significantly associated with shorter survival.
    [Cancer Gene Therapy]

    AbstractGraphical Abstract

    Stem Cells Derived Exosomes as Biological Nano Carriers for VCR Sulfate for Treating Breast Cancer Stem Cells

    Investigators isolated exosomes (Exos) from MSCs, and using probe-sonication approach loaded them with vincristine (VCR) sulfate. Using SRB assay, the cytotoxicity of VCR sulfate-Exo was assessed in T47D breast cancer cells, and the results were contrasted with those of free VCR sulfate.
    [Scientific Reports]

    Full Article

    Nucleoporin 93 Regulates Cancer Cell Growth and Stemness in Bladder Cancer via Wnt/β-Catenin Signaling

    Bladder cancer cells were used to investigate the effects of Nup93 overexpression or knockdown on cell growth, invasion, stemness , and Wnt/β-catenin signaling in vitro.
    [Molecular Biotechnology]

    Abstract
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    REVIEWS

    Cancer Stem-Like Cells in Uveal Melanoma: Novel Insights and Therapeutic Implications

    Scientists discuss the state of the art of CSC biology and their potential exploitation as therapeutic target in uveal melanoma.
    [Biochimica Et Biophysica Acta-Reviews On Cancer]

    Full ArticleGraphical Abstract

    Recommendations for Reporting Tissue and Circulating Tumor (ct)DNA Next-Generation Sequencing Results in Non-Small Cell Lung Cancer

    Scientists discuss next-generation sequencing workflows, the structure of next-generation sequencing reports, and our recommendations for best practice thereof.
    [British Journal Of Cancer]

    Full Article

    Iron Metabolism: Backfire of Cancer Cell Stemness and Therapeutic Modalities

    Investigators explore recent advances in iron metabolism in CSCs, conventional cancer therapies targeting iron biochemistry, therapeutic resistance in these cells, and potential treatment options that could overcome them.
    [Cancer Cell International]

    Full Article
    INDUSTRY AND POLICY NEWS

    Intensity Therapeutics, Inc. and The Swiss Group for Clinical Cancer Research SAKK Sign a Collaboration Agreement to Conduct a Phase II Randomized, Clinical Trial in Early-Stage Breast Cancer in Europe for INT230-6, Intensity’s Lead Drug Candidate

    Intensity Therapeutics, Inc. announced that they executed a collaboration agreement with The Swiss Group for Clinical Cancer Research SAKK to conduct a Phase II randomized, controlled trial evaluating clinical and biological effects of intratumoral INT230-6 in early-stage triple-negative breast cancer.
    [Intensity Therapeutics, Inc.]

    Press Release

    $5 Million Grant Supports Innovative Immunotherapies against Blood Cancers

    Researchers at Washington University School of Medicine in St. Louis have received a $5 million grant from the Leukemia & Lymphoma Society to support research aimed at developing new immunotherapies for different types of blood-based cancers.
    [Washington University School of Medicine in St. Louis]

    Press Release
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