| Vol. 13.13 – 15 May, 2024 |
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| Using a combination of transcriptomic, proteomic, and phosphoproteomic analyses, longitudinal imaging, and other assays, investigators demonstrated that chemoradiation and brain vasculature induce cell transition to a functional state named vessel co-opting and resistant cell state. [Nature Communications] |
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PUBLICATIONSRanked by the impact factor of the journal |
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| SMYD2-induced PGC1α methylation and followed nuclear export was confirmed by co-immunoprecipitation, cellular fractionation, and immunofluorescence. [Neuro-Oncology] |
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| Researchers designed a bispecific T cell engager capable of cross-linking CD3 on T cells with NKG2DL-expressing GBM cells. They then engineered the G207 virus to express the NKG2D BiTE and secrete it from infected cells. [Journal For Immunotherapy Of Cancer] |
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| The authors generated GPC3-targeted CAR-T cells overexpressing GLUT1 or AGK for the treatment of HCC. GPC3-targeted CAR-T cells overexpressing GLUT1 or AGK specifically and effectively lysed GPC3-positive tumor cells in vitro in an antigen-dependent manner. [Acta Pharmacologica Sinica] |
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| In vitro and in vivo experiments confirmed that overexpression of Circ-0075305 could effectively reduce stem cell-like properties and enhanced the sensitivity of gastric cancer cells to Oxaliplatin compared with the control group. [Communications Biology] |
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| The authors showed that CD271 mRNA, but not CD271 protein, facilitated spheroid cell proliferation. They established CD271−/− cells lacking both mRNA and protein of CD271, as well as CD271 protein knockout cells lacking only CD271 protein, from hypopharyngeal and oral squamous cell carcinoma lines. [Cancer Science] |
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| Researchers reported that TRIM58 was underexpressed in TNBC tissues and cells compared to adjacent mucosa tissue, and its downregulation was significantly associated with shorter survival. [Cancer Gene Therapy] |
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| Investigators isolated exosomes (Exos) from MSCs, and using probe-sonication approach loaded them with vincristine (VCR) sulfate. Using SRB assay, the cytotoxicity of VCR sulfate-Exo was assessed in T47D breast cancer cells, and the results were contrasted with those of free VCR sulfate. [Scientific Reports] |
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| Bladder cancer cells were used to investigate the effects of Nup93 overexpression or knockdown on cell growth, invasion, stemness , and Wnt/β-catenin signaling in vitro. [Molecular Biotechnology] |
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| Scientists discuss the state of the art of CSC biology and their potential exploitation as therapeutic target in uveal melanoma. [Biochimica Et Biophysica Acta-Reviews On Cancer] |
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| Scientists discuss next-generation sequencing workflows, the structure of next-generation sequencing reports, and our recommendations for best practice thereof. [British Journal Of Cancer] |
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| Investigators explore recent advances in iron metabolism in CSCs, conventional cancer therapies targeting iron biochemistry, therapeutic resistance in these cells, and potential treatment options that could overcome them. [Cancer Cell International] |
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| Intensity Therapeutics, Inc. announced that they executed a collaboration agreement with The Swiss Group for Clinical Cancer Research SAKK to conduct a Phase II randomized, controlled trial evaluating clinical and biological effects of intratumoral INT230-6 in early-stage triple-negative breast cancer. [Intensity Therapeutics, Inc.] |
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| Researchers at Washington University School of Medicine in St. Louis have received a $5 million grant from the Leukemia & Lymphoma Society to support research aimed at developing new immunotherapies for different types of blood-based cancers. [Washington University School of Medicine in St. Louis] |
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| June 13 – 16, 2024 Madrid, Spain & Online |
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| The University of Texas MD Anderson Cancer Center – Houston, Texas, United States |
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| BC Cancer – Vancouver, British Columbia, Canada |
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| University of Copenhagen – Copenhagen, Denmark |
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| Case Western Reserve University – Cleveland, Ohio, United States |
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| Cedars-Sinai Medical Center – Los Angeles, California, United States |
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