Cancer Stem Cell News Volume 13.23 | Oct 2 2024

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    2024-10-02 | CSCN 13.23



    Cancer Stem Cell News by STEMCELL Technologies
    Vol. 13.23 – 2 October, 2024
    TOP STORY

    RNA m5C Oxidation by TET2 Regulates Chromatin State and Leukaemogenesis

    The authors showed that chromatin-associated retrotransposon RNA 5-methylcytosine (m5C) could be recognized by the methyl-CpG-binding-domain protein MBD6, which guided deubiquitination of nearby monoubiquitinated Lys119 of histone H2A to promote an open chromatin state.
    [Nature]

    Full Article

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    PUBLICATIONSListed by the impact factor of the journal

    Interleukin-34-Orchestrated Tumor-Associated Macrophage Reprogramming Is Required for Tumor Immune Escape Driven by p53 Inactivation

    Scientists found that CSCs established an interleukin-34-orchestrated niche to promote tumorigenesis in p53-inactivated liver cancer.
    [Immunity]

    Full ArticleGraphical Abstract

    Combinations of HDAC Inhibitor and PPAR Agonist Induce Ferroptosis of Leukemic Stem Cell-Like Cells in Acute Myeloid Leukemia

    Leukemia stem cell-like cell lines, CD34+ primary AML cells purified from AML patients treated with CS055 and/or chiglitazar and were analyzed for viability, death, and colony formation assay.
    [Clinical Cancer Research]

    Abstract

    Nivolumab in Patients with Metastatic Castration-Resistant Prostate Cancer with and without DNA Repair Defects

    Researchers conducted a Phase II, multi-center, single-arm trial evaluating nivolumab in post-docetaxel metastatic castration-resistant prostate cancer patients. DNA repair defects was assessed using circulating tumor DNA.
    [Clinical Cancer Research]

    Abstract

    An ILK/STAT3 Pathway Controls Glioblastoma Stem Cell Plasticity

    Investigators showed that the extracellular matrix-cell adhesion protein integrin-linked kinase (ILK) stimulated phenotypic plasticity and mesenchymal-like, invasive behavior in a murine glioblastoma stem cell model.
    [Developmental Cell]

    Full ArticleGraphical Abstract

    Cellular Taxonomy of the Preleukemic Bone Marrow Niche of Acute Myeloid Leukemia

    Using an acute myeloid leukemia-murine model, researchers performed single-cell RNA-sequencing of preleukemic bone marrow microenvironment cells. They found normal HSC-regulating LepR+ mesenchymal stem cells, and endothelial cells were decreased, along with increases in CD55+ fibroblasts and pericytes.
    [Leukemia]

    Full Article

    Nuclear Receptor TLX Functions to Promote Cancer Stemness and EMT in Prostate Cancer via Its Direct Transactivation of CD44 and Stem Cell-Regulatory Transcription Factors

    Prostate cancer stem cells were isolated from various prostate cancer cell lines and clinical tumour tissues using multiple methods for various in vitro and in vivo oncogenic growth analyses.
    [British Journal of Cancer]

    AbstractGraphical Abstract

    ZFP64 Drives Glycolysis-Mediated Stem Cell-Like Properties and Tumorigenesis in Breast Cancer

    Researchers investigated whether zinc finger protein 64 (ZFP64) regulated stem cell-like properties and tumorigenesis in breast cancer by the glycolytic pathway.
    [Biology Direct]

    Full Article

    Targeting CREB-Binding Protein (CBP) Abrogates Colorectal Cancer Stemness through Epigenetic Regulation of C-MYC

    Investigators converted hiPSCs into cancer stem-like cells by culture with conditioned medium from colorectal cancer cells. These transformed cells, termed hiPSC-CSCs, displayed cancer stem-like properties, including a spheroid morphology and the expression of both pluripotency and CSC markers.
    [Cancer Gene Therapy]

    Abstract

    A Live Single-Cell Reporter System Reveals Drug-Induced Plasticity of a Cancer Stem Cell-Like Population in Cholangiocarcinoma

    Since dual expression of the core pluripotent factors SOX2/OCT4 has been shown to correlate with poor outcome in cholangiocarcinoma patients, researchers selected the SOX2/OCT4 activating short half-life GFP-based live reporter to study CSC dynamics at the single-cell level.
    [Scientific Reports]

    Full Article

    Integration of Single-Cell Sequencing and Bulk Transcriptome Data Develops Prognostic Markers Based on PCLAF+ Stem-Like Tumor Cells Using Artificial Neural Network in Gastric Cancer

    Stem-like tumor cells were identified by mining single-cell transcriptomic data from multiple samples. Integrated analysis of single-cell and bulk transcriptome data was performed to analyze the role of stem-like tumor cells in predicting clinical outcomes by introducing the intermediate variable mRNA stemness degree.
    [Heliyon]

    Full ArticleGraphical Abstract

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    REVIEWS

    Aneuploidy as a Driver of Human Cancer

    The authors delve into the context-dependent identification and functional characterization of the driver genes underlying driver aneuploidies and examine emerging strategies to uncover these driver genes using cancer genomics data and cancer models.
    [Nature Genetics]

    Abstract
    INDUSTRY AND POLICY NEWS

    Clinical Cancer Research in the US Increasingly Dominated by Pharmaceutical Industry Sponsors

    Researchers at Fred Hutch Cancer Center identified a substantial increase over the past decade in the proportion of patients with cancer in the US who participate in pharmaceutical industry sponsored clinical trials compared to those conducted with federal government support.
    [Fred Hutch]

    Press Release

    New Funding for Brain Cancer Research at UCL

    The announcement will support the Cancer Research UK Glioma Brain Tumor Centre of Excellence, a collaboration between UCL and the University of Edinburgh, whose work aims to better understand the disease and find new treatments.
    [UCL News]

    Press Release
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    November 4-6, 2024
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    JOB OPPORTUNITIES

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    Memorial Sloan Kettering Cancer Center – New York, New York, United States

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    Cancer Research UK – Manchester, England, United Kingdom

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    Dana-Farber Cancer Institute – Boston, Massachusetts, United States

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    Northwell Health – Manhasset, New York, United States

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