| Vol. 13.23 – 2 October, 2024 |
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| The authors showed that chromatin-associated retrotransposon RNA 5-methylcytosine (m5C) could be recognized by the methyl-CpG-binding-domain protein MBD6, which guided deubiquitination of nearby monoubiquitinated Lys119 of histone H2A to promote an open chromatin state. [Nature] |
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PUBLICATIONSListed by the impact factor of the journal |
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| Scientists found that CSCs established an interleukin-34-orchestrated niche to promote tumorigenesis in p53-inactivated liver cancer. [Immunity] |
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| Leukemia stem cell-like cell lines, CD34+ primary AML cells purified from AML patients treated with CS055 and/or chiglitazar and were analyzed for viability, death, and colony formation assay. [Clinical Cancer Research] |
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| Researchers conducted a Phase II, multi-center, single-arm trial evaluating nivolumab in post-docetaxel metastatic castration-resistant prostate cancer patients. DNA repair defects was assessed using circulating tumor DNA. [Clinical Cancer Research] |
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| Investigators showed that the extracellular matrix-cell adhesion protein integrin-linked kinase (ILK) stimulated phenotypic plasticity and mesenchymal-like, invasive behavior in a murine glioblastoma stem cell model. [Developmental Cell] |
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| Using an acute myeloid leukemia-murine model, researchers performed single-cell RNA-sequencing of preleukemic bone marrow microenvironment cells. They found normal HSC-regulating LepR+ mesenchymal stem cells, and endothelial cells were decreased, along with increases in CD55+ fibroblasts and pericytes. [Leukemia] |
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| Prostate cancer stem cells were isolated from various prostate cancer cell lines and clinical tumour tissues using multiple methods for various in vitro and in vivo oncogenic growth analyses. [British Journal of Cancer] |
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| Researchers investigated whether zinc finger protein 64 (ZFP64) regulated stem cell-like properties and tumorigenesis in breast cancer by the glycolytic pathway. [Biology Direct] |
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| Investigators converted hiPSCs into cancer stem-like cells by culture with conditioned medium from colorectal cancer cells. These transformed cells, termed hiPSC-CSCs, displayed cancer stem-like properties, including a spheroid morphology and the expression of both pluripotency and CSC markers. [Cancer Gene Therapy] |
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| Since dual expression of the core pluripotent factors SOX2/OCT4 has been shown to correlate with poor outcome in cholangiocarcinoma patients, researchers selected the SOX2/OCT4 activating short half-life GFP-based live reporter to study CSC dynamics at the single-cell level. [Scientific Reports] |
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| Stem-like tumor cells were identified by mining single-cell transcriptomic data from multiple samples. Integrated analysis of single-cell and bulk transcriptome data was performed to analyze the role of stem-like tumor cells in predicting clinical outcomes by introducing the intermediate variable mRNA stemness degree. [Heliyon] |
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| The authors delve into the context-dependent identification and functional characterization of the driver genes underlying driver aneuploidies and examine emerging strategies to uncover these driver genes using cancer genomics data and cancer models. [Nature Genetics] |
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| Researchers at Fred Hutch Cancer Center identified a substantial increase over the past decade in the proportion of patients with cancer in the US who participate in pharmaceutical industry sponsored clinical trials compared to those conducted with federal government support. [Fred Hutch] |
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| The announcement will support the Cancer Research UK Glioma Brain Tumor Centre of Excellence, a collaboration between UCL and the University of Edinburgh, whose work aims to better understand the disease and find new treatments. [UCL News] |
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| November 4-6, 2024 Montreal, Quebec, Canada |
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| Memorial Sloan Kettering Cancer Center – New York, New York, United States |
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| BC Provincial Health Services Authority – Vancouver, British Columbia, Canada |
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| Cancer Research UK – Manchester, England, United Kingdom |
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| Dana-Farber Cancer Institute – Boston, Massachusetts, United States |
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| Northwell Health – Manhasset, New York, United States |
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