 | | Vol. 12.38 – 11 October, 2023 |
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| Investigators demonstrated that the immune checkpoint T cell immunoglobulin mucin-3 (TIM-3) was highly expressed in both tumor cells and microenvironmental cells, mainly microglia and macrophages, in diffuse intrinsic pontine glioma.
[Cancer Cell] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers confirmed that BBI608 could efficiently suppress the proliferation and migration of non-small cell lung cancer (NSCLC) cells, and specifically kill the stemness-high population in chemoresistant NSCLC cells.
[Journal Of Controlled Release] |
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| The authors used patient-derived, typically resistant, glioma stem-like cells in combination with the previously validated preclinical Inovitro™ TTFields system together with a number of therapeutic DNA damage response inhibitors.
[British Journal Of Cancer] |
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| PLXNB3 bound to and activated the MET receptor tyrosine kinase, leading to activation of the SRC non-receptor tyrosine kinase and subsequently focal adhesion kinase, which promotes cancer cell migration and invasion.
[Stem Cells Translational Medicine] |
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| Researchers performed on enriched populations of triple-negative breast cancer CSCs demonstrate that MUC1-C was essential for integrating activation of glycolytic pathway genes with self-renewal and tumorigenicity.
[iScience] |
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| Scientists successfully established various novel canine canine pulmonary adenocarcinoma cell lines from a single lesion in a dog, including two parent cell lines and fourteen cloned cell lines, and characterized their cellular properties in vitro.
[Scientific Reports] |
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| Leucine-rich pentatricopeptide repeat containing (LRPPRC) level in osteosarcoma cells and CSCs were detected by western blot. Effects of LRPPRC on CSCs were accessed after LRPPRC knockdown by introducing lentivirus containing shRNA targeting to LRPPRC mRNA.
[BMC Cancer] |
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| The authors evaluated individual sphere proliferation and stemness toward chemotherapeutic treatment with doxorubicin and cisplatin in bladder cancer cell lines cultured in microfluidic devices used as CSC treatment response platform.
[Journal Of Molecular Medicine] |
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| Researchers developed spheroid cultures of patient-derived BRAFmut and KRASmut tumor cells and studied resistance mechanisms to inhibition of MAPK pathway through phenotypic and gene and protein expression analysis.
[Oncotarget] |
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| Stem cells can renew themselves without differentiating. Aging, inflammation, and environmental exposures may drive phenotypic changes in tissue stem cells that cause them to become CSCs.
[New England Journal Of Medicine] |
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| Scientists highlight the intricate strategies employed by CSCs to evade immune surveillance and develop resistance to therapies. They examine the dynamic interplay between CSCs and the tumor microenvironment, shedding light on how this interaction impacts cancer progression.
[Journal Of Translational Medicine] |
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| Dr. James Benson and Dr. Laura Hopkins believe the University of Saskatchewan has the tools to provide groundbreaking cancer treatment services to women across Canada.
[SaskToday] |
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| University of California San Diego cancer biologist Tatiana Hurtado de Mendoza has been named the recipient of the 2023 Claugus Award for Medical Research. The award was established in 2021 by the Foundation For A Better World.
[UC San Diego] |
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| November 15 – 17, 2023
Seoul, Korea |
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| | St. Anna Children’s Cancer Research Institute – Vienna, Austria |
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| | Texas Tech University Health Sciences Center El Paso – El Paso, Texas, United States |
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| | University of San Francisco – San Francisco, California, United States |
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| | NYU Medical Center – New York, New York, United States |
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| | University of Nebraska Medical Center – Omaha, Nebraska, United States |
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