Cancer Stem Cell News Volume 12.38 | Oct 11 2023

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    2023-10-11 | CSCN 12.38


    Cancer Stem Cell News by STEMCELL Technologies
    Vol. 12.38 – 11 October, 2023
    TOP STORY

    TIM-3 Blockade in Diffuse Intrinsic Pontine Glioma Models Promotes Tumor Regression and Antitumor Immune Memory

    Investigators demonstrated that the immune checkpoint T cell immunoglobulin mucin-3 (TIM-3) was highly expressed in both tumor cells and microenvironmental cells, mainly microglia and macrophages, in diffuse intrinsic pontine glioma.
    [Cancer Cell]

    Full ArticleGraphical Abstract
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    PUBLICATIONSRanked by the impact factor of the journal

    A Redox-Responsive Nanosystem to Suppress Chemoresistant Lung Cancer through Targeting STAT3

    Researchers confirmed that BBI608 could efficiently suppress the proliferation and migration of non-small cell lung cancer (NSCLC) cells, and specifically kill the stemness-high population in chemoresistant NSCLC cells.
    [Journal Of Controlled Release]

    Abstract

    DNA Damage Response Inhibitors Enhance Tumor Treating Fields (TTFields) Potency in Glioma Stem-Like Cells

    The authors used patient-derived, typically resistant, glioma stem-like cells in combination with the previously validated preclinical Inovitro™ TTFields system together with a number of therapeutic DNA damage response inhibitors.
    [British Journal Of Cancer]

    Full Article

    Mechanisms of Breast Cancer Stem Cell Specification and Self-Renewal Mediated by Hypoxia-Inducible Factor 1

    PLXNB3 bound to and activated the MET receptor tyrosine kinase, leading to activation of the SRC non-receptor tyrosine kinase and subsequently focal adhesion kinase, which promotes cancer cell migration and invasion.
    [Stem Cells Translational Medicine]

    Full Article

    Graphical Abstract

    Muc1-C Integrates Aerobic Glycolysis with Suppression of Oxidative Phosphorylation in Triple-Negative Breast Cancer Stem Cells

    Researchers performed on enriched populations of triple-negative breast cancer CSCs demonstrate that MUC1-C was essential for integrating activation of glycolytic pathway genes with self-renewal and tumorigenicity.
    [iScience]

    AbstractFull ArticleGraphical Abstract

    Phenotypic and Molecular Characterization of Novel Pulmonary Adenocarcinoma Cell Lines Established from a Dog

    Scientists successfully established various novel canine canine pulmonary adenocarcinoma cell lines from a single lesion in a dog, including two parent cell lines and fourteen cloned cell lines, and characterized their cellular properties in vitro.
    [Scientific Reports]

    Full Article

    LRPPRC Regulates Malignant Behaviors, Protects Mitochondrial Homeostasis, Mitochondrial Function in Osteosarcoma and Derived Cancer Stem-Like Cells

    Leucine-rich pentatricopeptide repeat containing (LRPPRC) level in osteosarcoma cells and CSCs were detected by western blot. Effects of LRPPRC on CSCs were accessed after LRPPRC knockdown by introducing lentivirus containing shRNA targeting to LRPPRC mRNA.
    [BMC Cancer]

    Full Article

    Microdevices for Cancer Stem Cell Culture as a Predictive Chemotherapeutic Response Platform

    The authors evaluated individual sphere proliferation and stemness toward chemotherapeutic treatment with doxorubicin and cisplatin in bladder cancer cell lines cultured in microfluidic devices used as CSC treatment response platform.
    [Journal Of Molecular Medicine]

    Abstract

    Inhibiting BRAF/EGFR/MEK Suppresses Cancer Stemness and Drug Resistance of Primary Colorectal Cancer Cells

    Researchers developed spheroid cultures of patient-derived BRAFmut and KRASmut tumor cells and studied resistance mechanisms to inhibition of MAPK pathway through phenotypic and gene and protein expression analysis.
    [Oncotarget]

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    REVIEWS

    Stem-Cell Aging and Pathways to Precancer Evolution

    Stem cells can renew themselves without differentiating. Aging, inflammation, and environmental exposures may drive phenotypic changes in tissue stem cells that cause them to become CSCs.
    [New England Journal Of Medicine]

    Abstract

    Exploring the Dynamic Interplay Between Cancer Stem Cells and the Tumor Microenvironment: Implications for Novel Therapeutic Strategies

    Scientists highlight the intricate strategies employed by CSCs to evade immune surveillance and develop resistance to therapies. They examine the dynamic interplay between CSCs and the tumor microenvironment, shedding light on how this interaction impacts cancer progression.
    [Journal Of Translational Medicine]

    Full Article
    INDUSTRY AND POLICY NEWS

    USask Researchers Break Ground with Promising Cancer Treatment

    Dr. James Benson and Dr. Laura Hopkins believe the University of Saskatchewan has the tools to provide groundbreaking cancer treatment services to women across Canada.
    [SaskToday]

    Press Release

    UC San Diego Cancer Biologist Receives Claugus Award for Medical Research

    University of California San Diego cancer biologist Tatiana Hurtado de Mendoza has been named the recipient of the 2023 Claugus Award for Medical Research. The award was established in 2021 by the Foundation For A Better World.
    [UC San Diego]

    Press Release
    FEATURED EVENT

    AACR-KCA Joint Conference on Precision Medicine in Cancer

    November 15 – 17, 2023
    Seoul, Korea

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Position – Fusion Oncogene Driven Pediatric Tumors

    St. Anna Children’s Cancer Research Institute – Vienna, Austria

    Director – Center of Emphasis in Diabetes and Metabolism

    Texas Tech University Health Sciences Center El Paso – El Paso, Texas, United States

    Clinical Research Coordinator – Pediatric Oncology, Leukemia & Neuroblastoma

    University of San Francisco – San Francisco, California, United States

    Postdoctoral Positions – HER2+ Breast Cancer Cells

    NYU Medical Center – New York, New York, United States

    Oncologist – Leukemia

    University of Nebraska Medical Center – Omaha, Nebraska, United States

    > See All Jobs

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