 | | Vol. 12.39 – 18 October, 2023 |
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| The effect of LUBAC on sorafenib response was evaluated. The role of HOIL-1 in promoting sorafenib resistance and the CSCs properties of HCC were investigated in vitro and in vivo.
[Hepatology] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators evaluated the potential role of circulating extracellular vesicles from hronic obstructive pulmonary disease (COPD)subjects in lung cancer onset.
[Cell Death & Disease] |
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| Researchers utilized single-cell transcriptome sequencing to uncover the molecular mechanisms by which the CHI3L1/MAF/CTLA4 signaling pathway may mediate immune evasion in triple-negative breast cancer through the interaction between tumor stem cells and immune cells.
[Journal Of Translational Medicine] |
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| Investigators identified the downregulation of HOXA5 in prostate cancer (PCa) tissues based on the TCGA database and further verified in 30-paired PCa and adjacent normal tissues.
[Cell Death Discovery] |
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| The authors investigated the antitumor effect of berbamine, extracted from berberis amurensis, on prostate cancer stem cells.
[The Prostate] |
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| Scientists confirmed that BIRC5 was a key factor regulating CSCs and epithelial to mesenchymal transition (EMT). BIRC5 was simultaneously overexpressed in lung cancer stem cells and glioma stem cells, and when the expression was suppressed, the characteristics of CSCs disappeared.
[Biochemical And Biophysical Research Communications] |
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| Investigators demonstrated that Celastrus orbiculatus ethyl acetate extract (COE) displayed a strong inhibitory effect on GCSCs growth and CSCs markers. Moreover, COE was shown to efficiently inhibited the development of tumor spheres and accelerate GCSCs apoptosis.
[Journal Of Natural Medicines] |
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| Characteristics of CSCs-exosomes were examined by transmission electron microscope and nanoparticle tracking analysis. PKH67 dye was used to observe the cellular uptake of exosomes.
[BMC Urology] |
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| Scientists review recent developments in characterizing mutation accumulation in healthy tissues and compare mutation rates in stem cells during development and adult life with corresponding cancer risk.
[Cell Stem Cell] |
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| CSCs maintain the cancer cell plasticity, epithelial-to-mesenchymal transition, and epigenetic plasticity. EMT contributes to increased cell migration and greater diversity within tumors.
[Cancer And Metastasis Reviews] |
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| Some advanced forms of prostate cancer find it is able to evade treatment by using their immune system to resist the impact of drugs. Now scientists have discovered a way to stop it being able to do this, opening up the possibility of treatments for men left with little hope.
[The Guardian] |
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| Researchers at Washington University School of Medicine in St. Louis have received a Specialized Programs of Research Excellence grant from the National Cancer Institute (NCI) of the National Institutes of Health to support research and clinical trials aimed at improving therapies for pancreatic cancer.
[Washington University School of Medicine in St. Louis] |
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| November 28 – 30, 2023
Philadelphia, Pennsylvania, United States |
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| | Francis Crick Institute – London, England, United Kingdom |
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| | St. Anna Children’s Cancer Research Institute – Vienna, Austria |
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| | University of Turku – Turku, Finland |
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| | Ume̴ University РUme̴, Sweden |
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| | Fred Hutchinson Cancer Center – Seattle, Washington, United States |
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