Cancer Stem Cell News Volume 12.39 | Oct 18 2023


    2023-10-18 | CSCN 12.39

    Cancer Stem Cell News by STEMCELL Technologies
    Vol. 12.39 – 18 October, 2023

    Noncanonical Regulation of HOIL-1 on Cancer Stemness and Sorafenib Resistance Identifies Pixantrone as a Novel Therapeutic Agent for Hepatocellular Carcinoma

    The effect of LUBAC on sorafenib response was evaluated. The role of HOIL-1 in promoting sorafenib resistance and the CSCs properties of HCC were investigated in vitro and in vivo.

    AbstractGraphical Abstract
    Watch the webinar where Dr. Suzan Imren discusses factors affecting the balance between HSC self-renewal and leukemic transformation
    PUBLICATIONSRanked by the impact factor of the journal

    Extracellular Vesicles from Subjects with COPD Modulate Cancer Initiating Cells Phenotype through HIF-1α Shuttling

    Investigators evaluated the potential role of circulating extracellular vesicles from hronic obstructive pulmonary disease (COPD)subjects in lung cancer onset.
    [Cell Death & Disease]

    Full Article

    Cancer Stem Cell-Derived CHI3L1 Activates the MAF/CTLA4 Signaling Pathway to Promote Immune Escape in Triple-Negative Breast Cancer

    Researchers utilized single-cell transcriptome sequencing to uncover the molecular mechanisms by which the CHI3L1/MAF/CTLA4 signaling pathway may mediate immune evasion in triple-negative breast cancer through the interaction between tumor stem cells and immune cells.
    [Journal Of Translational Medicine]


    TRAF7-Targeted HOXA5 Acts as a Tumor Suppressor in Prostate Cancer Progression and Stemness via Transcriptionally Activating SPRY2 and Regulating MEK/ERK Signaling

    Investigators identified the downregulation of HOXA5 in prostate cancer (PCa) tissues based on the TCGA database and further verified in 30-paired PCa and adjacent normal tissues.
    [Cell Death Discovery]

    Full ArticleGraphical Abstract

    Berbamine Targets Cancer Stem Cells and Reverses Cabazitaxel Resistance via Inhibiting IGF2BP1 and P-STAT3 in Prostate Cancer

    The authors investigated the antitumor effect of berbamine, extracted from berberis amurensis, on prostate cancer stem cells.
    [The Prostate]

    Full Article

    BIRC5: A Novel Therapeutic Target for Lung Cancer Stem Cells and Glioma Stem Cells

    Scientists confirmed that BIRC5 was a key factor regulating CSCs and epithelial to mesenchymal transition (EMT). BIRC5 was simultaneously overexpressed in lung cancer stem cells and glioma stem cells, and when the expression was suppressed, the characteristics of CSCs disappeared.
    [Biochemical And Biophysical Research Communications]

    Full Article

    Celastrus orbiculatus Extract Suppresses Gastric Cancer Stem Cells through the TGF-β/Smad Signaling Pathway

    Investigators demonstrated that Celastrus orbiculatus ethyl acetate extract (COE) displayed a strong inhibitory effect on GCSCs growth and CSCs markers. Moreover, COE was shown to efficiently inhibited the development of tumor spheres and accelerate GCSCs apoptosis.
    [Journal Of Natural Medicines]


    Exosomal miR-105-5p Derived from Bladder Cancer Stem Cells Targets for GPR12 to Promote the Malignancy of Bladder Cancer

    Characteristics of CSCs-exosomes were examined by transmission electron microscope and nanoparticle tracking analysis. PKH67 dye was used to observe the cellular uptake of exosomes.
    [BMC Urology]

    Full Article
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    Stem Cell Mutations, Associated Cancer Risk, and Consequences for Regenerative Medicine

    Scientists review recent developments in characterizing mutation accumulation in healthy tissues and compare mutation rates in stem cells during development and adult life with corresponding cancer risk.
    [Cell Stem Cell]

    Full Article

    Cancer Cell Plasticity, Stem Cell Factors, and Therapy Resistance: How Are They Linked?

    CSCs maintain the cancer cell plasticity, epithelial-to-mesenchymal transition, and epigenetic plasticity. EMT contributes to increased cell migration and greater diversity within tumors.
    [Cancer And Metastasis Reviews]


    New Prostate Cancer Treatment May Be ‘On the Horizon’, Say Scientists

    Some advanced forms of prostate cancer find it is able to evade treatment by using their immune system to resist the impact of drugs. Now scientists have discovered a way to stop it being able to do this, opening up the possibility of treatments for men left with little hope.
    [The Guardian]

    Press Release

    Pancreatic Cancer Research, Clinical Trials Supported with $10.9 Million NCI Grant

    Researchers at Washington University School of Medicine in St. Louis have received a Specialized Programs of Research Excellence grant from the National Cancer Institute (NCI) of the National Institutes of Health to support research and clinical trials aimed at improving therapies for pancreatic cancer.
    [Washington University School of Medicine in St. Louis]

    Press Release

    Cell Therapy for Autoimmune Disease Summit

    November 28 – 30, 2023
    Philadelphia, Pennsylvania, United States

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    Postdoctoral Fellow – Intestinal Stem Cell and Cancer

    Francis Crick Institute – London, England, United Kingdom

    Postdoctoral Position – Fusion Oncogene Driven Pediatric Tumors

    St. Anna Children’s Cancer Research Institute – Vienna, Austria

    Postdoctoral Researcher – Cancer Immunotherapy Research

    University of Turku – Turku, Finland

    Postdoctoral Scholarship – Structural Biology in Targeted Cancer Therapy

    Umeå University – Umeå, Sweden

    Assistant/Associate Professor – Prostate Cancer

    Fred Hutchinson Cancer Center – Seattle, Washington, United States

    > See All Jobs

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