Cancer Stem Cell News Volume 2.38 | Sep 25 2013

    Cancer Stem Cell News 2.38 September 25, 2013

    Cancer Stem Cell News

         In this issue: Publications | Reviews | Industry News | Policy News | Events | Jobs
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    c-Myc and Her2 Cooperate to Drive a Stem-Like Phenotype with Poor Prognosis in Breast Cancer
    Using a novel chimeric mammary transgenic approach and in vitro models, scientists demonstrated markedly increased self-renewal and tumor-propagating capability of cells transformed with Her2 and c-Myc. [Oncogene] Abstract
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    PUBLICATIONS (Ranked by impact factor of the journal)
    The Receptor Tyrosine Kinase Axl Regulates Cell-Cell Adhesion and Stemness in Cutaneous Squamous Cell Carcinoma
    Axl expression correlates with poor prognosis and induction of epithelial-mesenchymal transition, hence the authors hypothesized that Axl is involved in the disruption of cell-cell adhesion to allow invasion and chemotherapy resistance of the cancer stem cell population. [Oncogene] Abstract

    Stem Cell-Like ALDHbright Cellular States in EGFR-Mutant Non-Small Cell Lung Cancer: A Novel Mechanism of Acquired Resistance to Erlotinib Targetable with the Natural Polyphenol Silibinin
    The enrichment of cancer stem cell-like cellular states has not previously been considered to be a causative mechanism in the generalized progression of EGFR-mutant non-small cell lung carcinomas (NSCLC) after an initial response to the EGFR tyrosine kinase inhibitor erlotinib. To explore this possibility, investigators utilized a pre-clinical model of acquired erlotinib resistance established by growing NSCLC cells containing a TKI-sensitizing EGFR exon 19 deletion in the continuous presence of high doses of erlotinib. [Cell Cycle]
    Full Article

    Drug Screening Identifies Niclosamide as an Inhibitor of Breast Cancer Stem-Like Cells
    The authors aimed to discover novel compounds that target breast cancer stem-like cells. They used a dye-exclusion method to isolate side population (SP) cancer cells and, subsequently, subjected these SP cells to a sphere formation assay to generate SP spheres from breast cancer cell lines. [PLoS One] Full Article

    YB-1 Dependent Oncolytic Adenovirus Efficiently Inhibits Tumor Growth of Glioma Cancer Stem Like Cells
    Researchers determined the expression of YB-1 in glioblastoma specimen in vivo and in brain cancer stem cell (CSC) lines. In addition, the capacity of Ad-Delo3-RGD, an YB-1 dependent oncolytic adenovirus, to eradicate CSCs was evaluated both in vitro and in vivo. [J Transl Med] Abstract | Full Article

    Prognostic Value of Musashi-1 in Gliomas
    Scientists investigated the prognostic value of the RNA-binding protein Musashi-1 in adult patients with primary gliomas. Musashi-1 has been suggested to be a cancer stem cell-related marker in gliomas, and high levels of Musashi-1 have been associated with high tumor grades and hence poor prognosis. [J Neurooncol] Abstract

    Epithelial-Mesenchymal Transition Increases During the Progression of In Situ to Invasive Basal-Like Breast Cancer
    Investigators performed immunohistochemical analyses of epithelial-mesenchymal transition (EMT) markers (expression of vimentin, smooth muscle actin, osteonectin, and N-cadherin; loss of E-cadherin; alteration of β-catenin), breast cancer stem cell markers (CD44+/CD24-, ALDH1), and CD146, an EMT inducer, in invasive carcinomas and ductal carcinoma in situ of the breast. [Hum Pathol] Abstract

    Epigenetic Silencing of MicroRNA-203 Is Required for EMT and Cancer Stem Cell Properties
    Scientists profiled changes in microRNA expression during epithelial-mesenchymal transition (EMT) in conjunction with changes in DNA methylation at microRNA promoters to discover essential mediators of EMT-imparted stemness properties. [Sci Rep] Full Article

    Detect 7 times more prostate epithelial progenitors with ProstaCult

    Tumor Heterogeneity and Cancer Cell Plasticity
    Studies using lineage tracing and deep sequencing could have implications for the cancer stem-cell model and may help to determine the extent to which it accounts for therapy resistance and disease progression. [Nature] Full Article

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    Verastem Initiates Trial of Defactinib in Japan
    Verastem, Inc. announced the initiation of a Phase I trial of defactinib, a potent inhibitor of focal adhesion kinase (FAK), in Japanese patients with advanced solid tumors. FAK is a pathway critical for the growth and survival of cancer stem cells and the study marks the launch of Verastem’s development efforts in Japan. [Verastem, Inc.] Press Release

    OncoMed Pharmaceuticals Initiates Phase Ib/II Clinical Trial of Demcizumab (Anti-DLL4) in Combination with Paclitaxel in Ovarian Cancer
    OncoMed Pharmaceuticals, Inc. announced that it has started a Phase Ib/II clinical trial of its anti-cancer stem cell product candidate, demcizumab (OMP-21M18) in ovarian cancer. [The Wall Street Journal]
    Press Release

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    NEW San Antonio Breast Cancer Symposium
    December 10-14, 2013
    San Antonio, United States

    Visit our events page to see a complete list of events in the cancer stem cell community.

    NEW Postdoctoral Position – Breast Cancer Stem Cell Biology (UC College of Medicine)

    Research Associate – Leukemia & Stem Cell Biology (King’s College London)

    Tenure Track Faculty Positions – Cancer Biology (Memorial Sloan-Kettering Cancer Center)

    Assistant Professor – Developmental and Stem Cell Biology (METU Department of Biology)

    Principal Scientist – Cancer Stem Cells (Pharma Professionals Europe Ltd)

    Postdoctoral Appointee – Cell Cycle Regulation in Tumor Stem Cells (Rutgers University, Rutgers Cancer Institute of New Jersey)

    Research Technologist – Human Pluripotent Stem Cell Products (STEMCELL Technologies Inc.)

    Research Technologist – Mesenchymal Cell Research (STEMCELL Technologies Inc.)

    Research Technologist – Cell Culture Media & Matrices (STEMCELL Technologies Inc.)

    Research Associate/Scientist – Antibodies Group (STEMCELL Technologies Inc.)

    Research Associate – Particle Chemistry (STEMCELL Technologies Inc.)

    Quality Control Analyst – Media (STEMCELL Technologies Inc.)

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