Cancer Stem Cell News Volume 2.48 | Dec 4 2013

An In Vivo RNAi Screen Identifies SALL1 as a Tumor Suppressor in Human Breast Cancer with a Role in CDH1 Regulation
Scientists showed that inhibition of SALL correlates with reduced levels of CDH1, an important contributor to epithelial-to-mesenchymal transition. Furthermore, SALL1 expression led to an increased migration and more than twice as many cells expressing a cancer stem cell signature. [Oncogene] Full Article

LGR5 Positivity Defines Stem-Like Cells in Colorectal Cancer
Silencing of leucine-rich-repeat-containing G-protein-coupled receptor 5 (LGR5) in SW480 colorectal carcinoma cells resulted in a depletion of spheres but did not affect adherently growing cells. Spheres expressed higher levels of several stem cell-associated genes than adherent cells, including LGR5. [Carcinogenesis] Abstract

Prostaglandin E Receptor EP4 Is a Therapeutic Target in Breast Cancer Cells with Stem-Like Properties
Treatment of mammosphere-forming cells with Prostaglandin E receptor 4 (EP4) inhibitors (RQ-15986, AH23848, Frondoside A) or EP4 gene silencing, but not with a cyclooxygenase inhibitor (Indomethacin) reduces both mammosphere-forming capacity and the expression of phenotypic markers (CD44^hi/CD24^low, aldehyde dehydrogenase) of breast cancer stem cells. [Breast Cancer Res Treat] Full Article

Prognostic Value of Cancer Stem Cell Marker Aldehyde Dehydrogenase in Ovarian Cancer: A Meta-Analysis
Investigators aimed to evaluate the association between the expression of aldehyde dehydrogenase and the outcome of ovarian cancer patients by performing a meta-analysis. [PLoS One] Full Article

Differential Effects of Drugs Targeting Cancer Stem Cell (CSC) and Non-CSC Populations on Lung Primary Tumors and Metastasis
Researchers investigated the effect of salinomycin, a selective inhibitor of CSCs, with or without combination with paclitaxel, in a metastatic model. [PLoS One] Full Article

The Novel Myxofibrosarcoma Cell Line MUG-Myx1 Expresses a Tumorigenic Stem-Like Cell Population with High Aldehyde Dehydrogenase 1 Activity
A stem-like cell population with high enzymatic activity of aldehyde dehydrogenase 1 was isolated for the first time from myxofibrosarcoma cells using the ALDEFLUOR® assay followed by FACS analysis. [BMC Cancer] Abstract | Full Article

In Vitro and In Vivo Expression of Aldehyde Dehydrogenase 1 in Oral Squamous Cell Carcinoma
Scientists investigated whether alterations in Aldehyde dehydrogenase isoform 1 immunostaining and enzymatic activity in tumor cell populations predicted clinicopathological factors of prognostic importance for cancer progression and contributed to the characteristics of cancer-initiating cells in cisplatin-treated oral squamous cell cancer cells. [Int J Oncol] Abstract

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NEW Chief Medical Officer – Novel Therapeutics in Oncology and Autoimmune Disease (Immunomedics, Inc.)

NEW Postdoctoral Position – Apoptosis, Cancer Biology (Washington State University)

Postdoctoral Position – Skin Stem Cell and Cancer Biology (Karolinska Institutet)

Postdoctoral Position – Nervous System Development and Tumor Biology (Karolinska Institutet)

Postdoctoral Fellow – Breast Cancer Stem Cell Biology (University of Cincinnati)

Research Fellowship – Cancer Biology (Harvard Medical School)

Assistant Professor – Fundamental Mechanisms in Cancer Biology (Cornell University)

Faculty Position – Stem Cell Biology (University of Notre Dame)

Postdoctoral Position – Translational Research Studying Glioblastoma Biology (UC San Francisco)

Scientist – Particle Chemistry (STEMCELL Technologies Inc.)

Research Technologist – Human Pluripotent Stem Cell Products (STEMCELL Technologies Inc.)

Research Associate/Scientist – Antibodies Group (STEMCELL Technologies Inc.)

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