 | | Vol. 12.37 – 20 September, 2023 |
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| Targeting the protein subcomplex in pancreatic cancer stem cells with a KMT2A-WDR5 inhibitor attenuated their self-renewal capacity, cell viability, and in vivo tumorigenicity.
[Nature Communications] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators cultured circulating tumor cells-like DU4475 triple negative breast cancer cells in mechanically tunable 3D fibrin hydrogel scaffolds. They showed that fibrin hydrogels supported DU4475 cell growth, resulting in spheroid formation.
[Advanced Healthcare Materials] |
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| ABCG2 was found to be markedly up–regulated in colorectal cancer (CRC) CSCs expansion and chemo–resistant CRC tissues and closely associated with CRC recurrence.
[PLOS Biology] |
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| The effects of bone marrow mesenchymal stem cell-derived extracellular vesicles enriched with GTF2I were evaluated on the epithelial–to–mesenchymal transition and stemness maintenance in thyroid carcinoma.
[Frontiers Of Medicine] |
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| Phenotypic effects of ubiquitin-specific peptidase 5 on the CSC-like properties and metastasis were examined by in vitro sphere formation assay, migration assay, invasion assay, and in vivo xenografted animal models.
[Cancer Cell International] |
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| Scientists investigated the functional mechanism by which Porphyromonas gingivalis (Pg) promoted esophageal squamous cell carcinoma chemoresistance and malignancy through inhibiting PDCD4 and enriching CSCs.
[ACS Infectious Diseases] |
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| Hub long interspersed nuclear element-1 (LINE01) antisense promoter-associated genes CENPU and MCM2 showed a correlation with immune infiltration, clinical T stage, and cancer stemness in pan-cancer.
[Mobile DNA] |
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| Researchers examined the expression profiles of ion transport-related molecules in the CSCs of esophageal adenocarcinoma.
[Annals Of Surgical Oncology] |
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| Scientists explored the influence of myelin protein zero-like protein 1 (MPZL1) on the stem-like properties of cancer cells and the underlying mechanism in lung adenocarcinoma.
[Functional & Integrative Genomics] |
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| The authors document the critical role of the gut microbiota on the therapeutic efficacy of existing anticancer drugs by altering the cancer plasticity.
[Cancer And Metastasis Reviews] |
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| Revolution Medicines, Inc. announced the first patient was dosed in its Phase I/Ib monotherapy clinical trial of RMC-9805, an oral, covalent, mutant-selective KRASG12D(ON) Inhibitor designed to treat patients with cancers driven by the KRASG12D mutation.
[Revolution Medicines, Inc. ] |
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| October 19 – 22, 2023
San Diego, California, United States |
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| | Baylor College of Medicine – Houston, Texas, United States |
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| | University of Houston – Houston, Texas, United States |
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| | King’s College London – London, England, United Kingdom |
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| | Chinese Academy of Sciences – Shanghai, China |
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| | Northwestern University – Chicago, Illinois, United States |
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