Dominant-Negative Ikaros Cooperates with BCR-ABL1 to Induce Human Acute Myeloid Leukemia in Xenografts Ik6 induced transcriptional programs in BCR-ABL1 transduced progenitors that contained repressed B cell progenitor programs, along with strong stemness, proliferation, and granulocyte-monocytic progenitor signatures; a novel combination not induced in control groups. [Leukemia] Abstract Progranulin Promotes Temozolomide Resistance of Glioblastoma by Orchestrating DNA Repair and Tumor Stemness Researchers showed that progranulin (PGRN) was overexpressed in most glioblastoma multiforme (GBM) cell lines and the majority of human tumor samples. PGRN overexpression conferred GBM cells with tumorigenic properties and temozolomide resistance by upregulating DNA repair and cancer stemness genes, in part via an AP-1 transcription factor, specifically cFos/JunB. [Oncogene] Abstract Chloroquine Targets Pancreatic Cancer Stem Cells via Inhibition of CXCR4 and Hedgehog Signaling Researchers screened established and new compounds for their ability to eliminate cancer stem cells in primary pancreatic cancer cells in vitro and corresponding patient-derived pancreatic cancer tissue xenografts in vivo. [Mol Cancer Ther] Abstract Anti-Neoplastic Activity of Low-Dose Endothelial-Monocyte Activating Polypeptide-II Results from Defective Autophagy and G2/M Arrest Mediated by PI3 K/Akt/FoxO1 Axis in Human Glioblastoma Stem Cells Investigators demonstrated that low-dose endothelial-monocyte activating polypeptide-II reduces cell viability and mitochondrial membrane potential in vitro. [Biochem Pharmacol] Abstract XAV939 Inhibits the Stemness and Migration of Neuroblastoma Cancer Stem Cells via Repression of Tankyrase 1 Scientists showed that the surface marker CD133 method was more suitable for isolating neuroblastoma (NB) cancer stem cells (CSCs) than the side-population method, and 60 µM etoposide was optimal for enriching NB CSCs. [Int J Oncol] Abstract Downregulation of SCAI Enhances Glioma Cell Invasion and Stem Cell Like Phenotype by Activating wnt/ß-Catenin Signaling Researchers found that levels of suppressor of cancer cell invasion (SCAI) protein and mRNA expression were significantly downregulated in glioma tissues and cell lines. Overexpression of SCAI inhibited, but silencing of SCAI robustly promoted the invasive and cancer stem cell-like phenotypes of glioma cells. [Biochem Biophys Res Commun] Abstract NOTCH1 Signaling Promotes Chemoresistance via Regulating ABCC1 Expression in Prostate Cancer Stem Cells Scientists revealed that the sorted prostate cancer stem cells (PCSCs) showed enhanced chemoresistance ability than matched non-PCSCs. Protein level of activated form of NOTCH1 was significantly higher in PCSCs. [Mol Cell Biochem] Abstract Wnt-Responsive Cancer Stem Cells Are Located Close to Distorted Blood Vessels and Not in Hypoxic Regions in a p53-Null Mouse Model of Human Breast Cancer Researchers analyzed the relationship between a Wnt-responsive, cancer stem cells-enriched population and the tumor vasculature using p53-null mouse mammary tumors transduced with a lentiviral Wnt signaling reporter. [Stem Cells Transl Med] Abstract |