Niche Displacement of Human Leukemic Stem Cells Uniquely Allows Their Competitive Replacement with Healthy HSPCs Scientists provide functional evidence that the spatial localization of phenotypically primitive human acute myeloid leukemia cells is restricted to niche elements shared with their normal counterparts, and that their intrinsic ability to initiate and retain occupancy of these niches can be rivaled by healthy hematopoietic stem and progenitor cells (HSPCs). [J Exp Med] Abstract
Arachidonate 15-Lipoxygenase Is Required for Chronic Myeloid Leukemia Stem Cell Survival Researchers determined that the gene encoding arachidonate 15-lipoxygenase (Alox15/15-LO) is essential for the survival of leukemia stem cells in a murine model of BCR-ABL-induced chronic myeloid leukemia (CML). In the absence of Alox15, BCR-ABL was unable to induce CML in mice. [J Clin Invest] Full Article
Metastatic Consequences of Immune Escape from NK Cell Cytotoxicity by Human Breast Cancer Stem Cells Scientists report that tumor-infiltrating natural killer (NK) cells failed to limit metastasis and were not associated with improved therapeutic outcome of breast cancer stem-like cell-rich breast cancer. [Cancer Res] Abstract
Involvement of Autophagy in Melatonin-Induced Cytotoxicity in Glioma-Initiating Cells Researchers evaluated the effect of the indolamine alone in glioblastoma initiating cells (GICs) and found that melatonin treatment reduces GICs proliferation and induces a decrease in self-renewal and clonogenic ability accompanied by a reduction in the expression of stem cell markers. [J Pineal Res] Abstract
Luminal Cells Are Favored as the Cell of Origin for Prostate Cancer Scientists used a novel lineage-tracing strategy to assess the cell of origin in a diverse range of mouse models as well as a hormonal carcinogenesis model. Their results show that luminal cells are consistently the observed cell of origin for each model in situ; however, explanted basal cells from these mice can generate tumors in grafts. [Cell Rep] Full Article | Graphical Abstract
Lipid Droplets: A New Player in Colorectal Cancer Stem Cells Unveiled by Spectroscopic Imaging Researchers show that high levels of lipid droplets are a distinctive mark of cancer stem cell (CSCs) in colorectal (CR) cancer. This increased lipid content was clearly revealed by label free Raman spectroscopy and it directly correlates with well-accepted CR-CSCs markers as CD133 and Wnt pathway activity. [Stem Cells] Abstract
Targeting the SMO Oncogene by miR-326 Inhibits Glioma Biological Behaviors and Stemness Researchers investigated whether targeting smoothened (SMO) with microRNA (miR)-326 would affect glioma biological behavior and stemness. [Neuro Oncol] Abstract
Ovarian Tumor-Initiating Cells Display a Flexible Metabolism The metabolic phenotype of cancer stem or tumor-initiating cells, small tumor cell populations that are able to recapitulate the original tumor, has not been well characterized. Scientists compared the metabolic phenotype of the stem cell enriched cell variant, MOSE-LFFLv, derived from mouse ovarian surface epithelial cells, to their parental and benign precursor cells. [Exp Cell Res] Abstract
EGCG Inhibits Properties of Glioma Stem-Like Cells and Synergizes with Temozolomide through Downregulation of P-Glycoprotein Inhibition Researchers examined the molecular mechanisms by which epigallocatechin gallate (EGCG), a bioactive polyphenol in green tea, inhibits the stem cell characteristics of glioma stem-like cells and synergizes with temozolomide, a DNA-methylating agent commonly used as first-line chemotherapy in gliomas. [J Neurooncol] Abstract
MicroRNA-29b-1 Impairs In Vitro Cell Proliferation, Self-Renewal and Chemoresistance of Human Osteosarcoma 3AB-OS Cancer Stem Cells After stable transfection of 3AB-OS cells with microRNA (miR)-29b-1, scientists investigated the role of miR-29b-1 in regulating cell proliferation, sarcosphere-forming ability, clonogenic growth, chemosensitivity, migration and invasive ability of 3AB-OS cells, in vitro. [Int J Oncol] Abstract
Neural Stem Cells Preferentially Migrate to Glioma Stem Cells and Reduce Their Stemness Phenotypes Researchers show that glioma stem cells (GSCs) exhibited enhanced chemotaxis for neural stem cell (NSC) tropism compared with their differentiated cells. Chemokines secreted by GSCs contributed to the targeted migration of NSCs. [Int J Oncol] Abstract
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