Stem Cells Increase in Numbers in Peri-Necrotic Areas in Human Renal Cancer Scientists hypothesized that sunitinib-induced tumor necrosis-associated hypoxia could interact with renal cancer stem-cells in patients with metastatic renal-cell carcinoma (RCC). When they studied the six RCC xenograft models at the time necrosis, whether spontaneous or sunitinib-induced, occurred, necrosis area correlated with stem-cell number in all 120 xenografted RCCs. [Clin Cancer Res] Abstract
Toll Like Receptor 4 Facilitates Invasion and Migration as a Cancer Stem Cell Marker in Hepatocellular Carcinoma Two hepatocellular carcinoma (HCC) cell lines and a splenic vein metastasis of the nude mouse model were used to study the invasive ability of toll like receptor 4 (TLR4) positive HCC cells in vitro and in vivo. Stem-like features were also detected in TLR4 positive HCC cells. [Cancer Lett] Abstract
Inhibition of Mesothelioma Cancer Stem-Like Cells with Adenovirus-Mediated NK4 Gene Therapy Researchers show that the NK4 adenovirus (Ad-NK4) potently inhibits cell viability, invasiveness, and tumorigenicity of human malignant mesothelioma (MM) cells. They demonstrate for the first time that Ad-NK4 inhibits cancer stem-like cell properties as assessed by spheroid formation assay, side population analysis, and flow cytometric sorting of CD24 cells. [Int J Cancer] Abstract
Honokiol Inhibits Melanoma Stem Cells by Targeting Notch Signaling Investigators determined the effects of honokiol (HNK), a biphenolic natural compound on melanoma cells and stemness. HNK significantly inhibited melanoma cell proliferation, viability, clonogenicity and induced autophagy. [Mol Carcinog] Abstract
Sevoflurane Promotes the Expansion of Glioma Stem Cells through Activation of Hypoxia-Inducible Factors In Vitro Scientists investigated the effect of sevoflurane on glioma stem cells (GSCs) in vitro and the underlying molecular mechanisms in this process. Cultured GSCs were exposed to clinically relevant concentrations and durations of sevoflurane exposure. Cell proliferation and self-renewal capacity were determined. [Br J Anaesth] Abstract
Salinomycin Exerts Anticancer Effects on Human Breast Carcinoma MCF-7 Cancer Stem Cells via Modulation of Hedgehog Signaling Salinomycin’s ability to modulate the activity of key elements in the Hedgehog pathway was examined in the human breast cancer cell line MCF-7, as well as in a subpopulation of cancer stem cells identified within this cancer cell line. [Chem Biol Interact] Abstract
MicroRNA-17 Promotes Normal Ovarian Cancer Cells to Cancer Stem Cells Development via Suppression of the LKB1-p53-p21/WAF1 Pathway Investigators examined the role of miR-17 in the expression of liver kinase protein (LKB1) and the downstream effects on proliferation and invasion capacity of normal ovarian cancer cells and ovarian stem cells. [Tumor Biol] Abstract
Pancreatic Ductal Adenocarcinoma Cell Lines Display a Plastic Ability to Bi‑Directionally Convert into Cancer Stem Cells Pancreatic ductal adenocarcinoma cancer stem cells were generally more resistant to the action of five anticancer drugs than parental cell lines and were characterized by an increased expression of EpCAM and CD44v6, typical stem cell surface markers, and a decreased expression of E-cadherin, the main marker of the epithelial state. [Int J Oncol] Abstract
A Flexible Reporter System for Direct Observation and Isolation of Cancer Stem Cells Researchers developed a flexible lentiviral-based reporter system that allows direct visualization of cancer stem cells based on functional properties. The reporter responds to the core stem cell transcription factors OCT4 and SOX2, with further selectivity and kinetic resolution coming from use of a proteasome-targeting degron. [Stem Cell Reports] Full Article | Graphical Abstract
|