Cancer Stem Cell News Volume 4.12 | Apr 1 2015

Cancer Stem Cell News 4.12 April 1, 2015

Cancer Stem Cell News

     In this issue: Publications | Reviews | Science News | Industry News | Policy News | Events | Jobs
Cell Therapy News on Facebook   CSCN on Twitter

ID4 Controls Mammary Stem Cells and Marks Breast Cancers with a Stem Cell-Like Phenotype
Researchers showed that ​inhibitor of differentiation 4 (​ID4) is a key regulator of mammary stem cell self-renewal and marks a subset of basal-like breast cancer with a putative mammary basal cell of origin. [Nat Commun] Abstract | Press Release
FREE Wallchart: Glioblastoma Multiforme

PUBLICATIONS (Ranked by impact factor of the journal)
Tenascin-C Protects Cancer Stem-Like Cells from Immune Surveillance by Arresting T Cell Activation
Researchers present evidence that prostate cancer stem-like cells (CSCs) can be found in histopathologically negative prostate draining lymph nodes (PDLN) in mice harboring oncogene-driven prostate intraepithelial neoplasia (mPIN). PDLN-derived CSCs were phenotypically and functionally identical to CSCs obtained from mPIN lesions, but distinct from CSCs obtained from frank prostate tumors. [Cancer Res] Abstract

CD133 and DNA-PK Regulate MDR1 via the PI3K- or Akt-NF-κB Pathway in Multidrug-Resistant Glioblastoma Cells In Vitro
Although CD133, DNA-dependent protein kinase (DNA-PK), and multidrug resistance protein 1 (MDR1) are elevated in CD133 positive glioma cancer stem-like cells, the relationship among these molecules has not been studied. Investigators report that CD133 and DNA-PK may increase MDR1 via the phosphatidylinositol-3-kinase (PI3K)-Akt signal pathway. [Oncogene] Abstract

Keratin 19, a Cancer Stem Cell Marker in Human Hepatocellular Carcinoma
Researchers determined whether keratin 19 (K19) can be used as a new cancer stem cell (CSC) marker and therapeutic target in hepatocellular carcinoma. CSC characteristics, epithelial-mesenchymal transition, and transforming growth factor beta/Smad signaling were examined in fluorescence-activated cell sorting-isolated K19+/K19 cells. [Clin Cancer Res] Abstract

The Rab2A GTPase Promotes Breast Cancer Stem Cells and Tumorigenesis via Erk Signaling Activation
Proline-directed phosphorylation is regulated by the prolyl isomerase Pin1, which plays a fundamental role in driving breast cancer stem-like cells (BCSCs). Scientists showed that Pin1 increases Rab2A transcription to promote BCSC expansion and tumorigenesis in vitro and in vivo. [Cell Rep] Full Article | Graphical Abstract

Progesterone Generates Cancer Stem Cells through Membrane Progesterone Receptor-Triggered Signaling in Basal-Like Human Mammary Cells
Scientists report that in irradiated MCF10A cells, progesterone activated the PI3k/Akt pathway via membrane progesterone receptor. Inhibition of the PI3k/Akt pathway counteracted the generation of cancer stem cells by progesterone and irradiation. [Cancer Lett] Abstract

Sialidase NEU3 Contributes Neoplastic Potential on Colon Cancer Cells as a Key Modulator of Gangliosides by Regulating Wnt Signaling
Researchers provide evidence of a close link between NEU3 expression and Wnt/β-catenin signaling in colon cancer cells by analyzing tumorigenic potential and cancer stem-like characteristics. [Int J Cancer] Abstract

Dopamine Enhances the Response of Sunitinib in the Treatment of Drug-Resistant Breast Cancer: Involvement of Eradicating Cancer Stem-Like Cells
The authors evaluated the effect of dopamine on the enhancement of sunitinib’s efficacy in the treatment of drug-resistant breast cancer, investigating the involved activation type of dopamine receptor pathway and exploring the underlying anti-cancer stem-like cells mechanisms. [Biochem Pharmacol] Abstract

Specific Preferences in Lineage Choice and Phenotypic Plasticity of Glioma Stem Cells under BMP4 and Noggin Influence
Investigators evaluated glioma stem cell-enriched cell lines behavior towards differentiating conditions by depriving them of growth factors and/or by adding BMP4 at different concentrations. [Brain Pathol] Abstract

Long Noncoding RNA MALAT-1 Enhances Stem Cell-Like Phenotypes in Pancreatic Cancer Cells
Researchers hypothesized that MALAT-1 might enhance stem cell-like phenotypes in pancreatic cancer cells. Their data showed that MALAT-1 could increase the proportion of pancreatic cancer stem cells, maintain self-renewing capacity, decrease the chemosensitivity to anticancer drugs, and accelerate tumor angiogenesis in vitro. [Int J Mol Sci] Abstract | Download Full Article

View Webinar: Genome Editing: From Modeling Disease to Novel Therapeutics

NANOG in Cancer Stem Cells and Tumor Development: An Update and Outstanding Questions
The authors surmise that NANOG potentiates the molecular circuitry of tumorigenesis, and thus may represent a novel therapeutic target or biomarker for the diagnosis, prognosis and treatment outcome of cancer. They also present critical pending questions relating NANOG to cancer stem cells and tumor development. [Stem Cells] Abstract

Visit our reviews page to see a complete list of reviews in the cancer stem cell research field.

Your Favorite Immunology Newsletters Are Now on Facebook! Like Us Today!

Cantrixil Proves Highly Effective at Killing Human Ovarian Stem Cells in Pre-Clinical Study
Novogen Ltd, its subsidiary, CanTx, Inc., and Yale University, released pre-clinical data on experimental anticancer drug, Cantrixil. In both in vitro and in animal studies, Cantrixil, has proved highly effective at killing human ovarian stem cells. [Press Release from Novogen Ltd discussing research presented at the 62nd Annual Scientific Meeting of the Society of Reproductive Investigation, San Francisco] Press Release

From our sponsor: Free mouse hematopoietic progenitors wallchart. Request your copy.

Taconic Biosciences and Cellaria Biosciences Agree to Scientific Collaboration to Facilitate Xenograft Use in Oncology Research
Taconic Biosciences and Cellaria Biosciences announced that the two companies have entered into a scientific collaboration designed to facilitate and improve the utility of patient-derived xenografts in animal models for oncology and immuno-oncology research. [Taconic Biosciences, Inc.] Press Release

Cancer Research UK Partners with the Engineering and Physical Sciences Research Council to Inspire Innovation
Cancer Research UK has partnered with the Engineering and Physical Sciences Research Council, to co-fund multidisciplinary research projects. The new partnership increases the amount of funding for collaborative research to up to £37.5 million over five years. [Cancer Research UK] Press Release

Global Oncology Launches Global Cancer Project Map to Improve Cancer Control Worldwide – in Collaboration with the National Cancer Institute
Nonprofit Global Oncology, Inc. (GO) announced the launch of the Global Cancer Project Map, a first-of-its-kind online resource and virtual information exchange for connecting the global cancer community. Developed by GO in collaboration with the National Cancer Institute Center for Global Health, the Map enables worldwide access to cancer projects and expertise to improve cancer practices and patient outcomes, especially in low-resource settings. [Global Oncology, Inc.] Press Release | Map

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

NEW Stem Cells: From Basic Research to Bioprocessing
June 9-11, 2015
London, United Kingdom

Visit our events page to see a complete list of events in the cancer stem cell community.

NEW Postdoctoral Scholar – Cancer Stem Cell Biology (Case Western Reserve University)

NEW Postdoctoral Position – Cancer Imaging (King’s College London)

Postdoctoral Position – Triple Negative Breast Cancer (King’s College London)

Postdoctoral Fellow – Breast Cancer & Stem Cell Biology (University of Cincinnati)

PhD Position – Peptide-Drug Conjugates for Targeted Delivery in Tumor Therapy (EXIRIS Oncology Research)

PhD Positions – Immunological Aspects of Cancer and Allergy (University of Salzburg)

Postdoctoral Positions – Stem Cell and Cancer (Brigham & Women’s Hospital)

Research Technician II – Pediatric Cancer and Stem Cells (Massachusetts General Hospital)

Recruit Top Talent: Reach more than 60,000 potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.


Have we missed an important article or publication in Cancer Stem Cell News? Click here to submit!

Comments or suggestions? Submit your feedback here

Learn more about Cancer Stem Cell News: Archives | Events | Contact Us