Cancer Stem Cell News Volume 4.24 | Jun 24 2015


    Cancer Stem Cell News 4.24 June 24, 2015

    Cancer Stem Cell News

         In this issue: Publications | Industry News | Policy News | Events | Jobs
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    Critical Role for the DNA Sensor AIM2 in Stem Cell Proliferation and Cancer
    Researchers found that Aim2-deficient mice were hypersusceptible to colonic tumor development. Aberrant Wnt signaling expanded a population of tumor-initiating stem cells in the absence of AIM2. [Cell]
    | Graphical Abstract | Press Release
    FREE Wallchart: Glioblastoma Multiforme

    PUBLICATIONS (Ranked by impact factor of the journal)
    Sox9 Controls Self-Renewal of Oncogene Targeted Cells and Links Tumor Initiation and Invasion
    Transcriptional profiling of oncogene-expressing cells with Sox9 deletion, combined with in vivo ChIP sequencing, uncovered a cancer-specific gene network regulated by Sox9 that promotes stemness, extracellular matrix deposition, and cytoskeleton remodeling while repressing epidermal differentiation. [Cell Stem Cell] Abstract | Graphical Abstract | Press Release

    Loss of ATOH8 Increases Stem Cell Features of Hepatocellular Carcinoma Cells
    The authors investigated the effects of loss of atonal homolog 8 (ATOH8) in human hepatocellular carcinoma cells and cell lines. ATOH8 repressed transcription of stem-cell associated genes including OCT4, NANOG, and CD133. [Gastroenterology] Abstract

    FOXM1-Induced PRX3 Regulates Stemness and Survival of Colon Cancer Cells via Maintenance of Mitochondrial Function
    Cancer stem cells (CSCs) had a higher mitochondrial membrane potential and increased levels of ATP, Ca2+, reactive oxygen species, and oxygen consumption than non-CSCs. Levels of PRX3 were increased in colon CSCs compared with non-CSCs. [Gastroenterology] Abstract

    LGR5 Promotes Breast Cancer Progression and Maintains Stem-Like Cells through Activation Of Wnt/β-Catenin Signaling
    To determine the mechanism of cancer stem cells (CSCs) in breast cancer, scientists focused on LGR5, a marker of adult stem cells that potentially serves as a functional factor in CSCs. LGR5 promoted cell mobility, tumor formation and EMT in breast cancer cells by activating Wnt/β-catenin signaling. [Stem Cells] Abstract

    A Microfluidic Platform for Studying Chemotaxis of Adhesive Cells Revealed a Gradient-Dependent Migration and Acceleration of Cancer Stem Cells
    Researchers developed a microfluidic device capable of generating multiple stable gradients, culturing cells on-chip, and monitoring single cell migratory behavior. The microfluidic platform was used to study gradient-induced chemotaxis of lung cancer stem cell and differentiated LCSC in real time. [Anal Chem] Abstract

    Targeting PBK/TOPK Decreases Growth and Survival of Glioma Initiating Cells In Vitro and Attenuates Tumor Growth In Vivo
    Researchers investigated a protein kinase, PBK/TOPK as a candidate for regulating growth, survival and in vivo tumorigenicity of glioma initiating cells (GICs). They assessed viability, tumorsphere formation and apoptosis in three patient derived GIC cultures. [Mol Cancer] Full Article

    Regulation of Non Small-Cell Lung Cancer Stem Cell Like Cells by Neurotransmitters and Opioid Peptides
    Epinephrine increased the number of cancer stem cell like cells from three non small-cell lung cancer cell lines in spheroid formation assays while enhancing intracellular cAMP and the stem cell markers sonic hedgehog, aldehyde dehydrogenase-1 and Gli1, effects reversed by GABA or dynorphin B via Gαi-mediated inhibition of cAMP formation. [Int J Cancer] Abstract

    Co-Eradication of Breast Cancer Cells and Cancer Stem Cells by Cross-Linked Multilamellar Liposomes Enhances Tumor Treatment
    A novel drug delivery system, cross-linked multilamellar liposomal vesicles, was optimized to allow for the co-delivery salinomycin and doxorubicin, targeting both cancer stem cells and breast cancer cells. [Mol Pharmaceut] Abstract

    Targeted Therapy for Breast Cancer Stem Cells by Liposomal Delivery of siRNA against Fibronectin EDB
    A novel liposomal system (APTEDB-LS-siRNAEDB) that enables simultaneous targeting and knockdown of extra domain B (EDB) of fibronectin showed potent therapeutic efficacy in breast cancer stem cell-derived tumors in vivo. [Adv Healthc Mater] Abstract

    Transforming Growth Factor-Beta1 Promotes the Migration and Invasion of Sphere-Forming Stem-Like Cell Subpopulations in Esophageal Cancer
    Scientists enriched and identified the esophageal cancer cell subpopulation with stem-like properties and helped to develop new target therapy strategies for cancer stem cells. [Exp Cell Res] Abstract

    Precursor States of Brain Tumor Initiating Cell Lines Are Predictive of Survival in Xenografts and Associated with Glioblastoma Subtypes
    Investigators applied a stem cell biology approach and compared self-renewal, marker expression, label retention, and asymmetric cell division in 20 brain-tumor-initiating cell (BTIC) lines. Through cluster analysis, they identified two subgroups of BTIC lines with distinct precursor states, stem- or progenitor-like, predictive of survival after xenograft. [Stem Cell Rep] Full Article

    MethoCult: The most published medium for mouse hematopoietic colony-forming unit (CFU) assays. Click here to learn more.

    ImmunoCellular Therapeutics Establishes Agreement with Pure MHC for Novel Quality Control Assay for ICT-107 Phase 3 Registrational Trial
    ImmunoCellular Therapeutics, Ltd. announced an agreement with Pure MHC, for development of a novel assay for quality control that will be an important component of ImmunoCellular’s ICT-107 Phase III registrational clinical program in newly diagnosed glioblastoma. Pure MHC will develop and validate a new assay specifically created for ICT-107, a dendritic-cell based immunotherapy targeting six antigens found on glioblastoma cells, especially stem cells. [ImmunoCellular Therapeutics, Ltd.] Press Release

    TGen and Mayo Clinic Help Launch National Clinical Trials to Combat Advanced Skin Cancer
    The Translational Genomics Research Institute (TGen) and Mayo Clinic are helping launch a national clinical trial that will apply the latest in precision medicine to treat advanced melanoma skin cancer. [Translational Genomics Research Institute] Press Release

    ERYTECH Announces Two Positive DSMB Reviews
    ERYTECH Pharma announced positive safety reviews after the completion of the first cohort in the company’s US Phase I study with ERY-ASP in acute lymphoblastic leukemia, and following the treatment of the first three patients with ERY-ASP in combination with Folfox in its Phase II study in pancreatic cancer. [ERYTECH Pharma] Press Release

    Ontario Invests in Better Health and Economic Opportunity through Support for Ontario Institute for Regenerative Medicine
    A new $25 million commitment positions Ontario to be an early adopter of new treatments and technologies emerging from research and commercial developments in regenerative medicine. [Ontario Institute for Regenerative Medicine] Press Release

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    NEW 3rd Annual International Conference on Advances in Medical Research (CAMR 2015)
    August 17-18, 2015
    Singapore, Singapore

    Visit our events page to see a complete list of events in the cancer stem cell community.

    NEW PhD Position – Anti-Cancer Nano-Particle Drug Testing: Cell Pathways and Cytotoxicity (University of Southern Denmark)

    NEW Postdoctoral Position – Cancer Cell Biology and Pharmacogenomics (University of Copenhagen)

    Research Associate – Cell Separation (STEMCELL Technologies Inc.)

    Postdoctoral Researcher – Tumor Immunology and Cancer Immunotherapy (University of California, Los Angeles)

    Postdoctoral Researcher – Cancer Immunotherapeutics (City of Hope)

    Professor – Cancer Stem Cells (Dalian Medical University)

    Research Technician (Fred Hutchinson Cancer Research Center)

    Research Associate/Assistant Professor – NeuroOncology (University of Chicago)

    Postdoctoral Positions – Cancer, Stem Cell, and Developmental Biology (Columbia University Medical Center)

    Postdoctoral Position – Cancer Research (INSERM)

    Recruit Top Talent: Reach more than 60,000 potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.


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