miR-205-5p-Mediated Downregulation of ErbB/HER Receptors in Breast Cancer Stem Cells Results in Targeted Therapy Resistance Researchers report that miR-205-5p is highly expressed in breast cancer stem cells and represses directly ERBB2 and indirectly EGFR leading to resistance to targeted therapy. [Cell Death Dis] Full Article CD34+ Liver Cancer Stem Cells Were Formed by Fusion of Hepatobiliary Stem/Progenitor Cells with Hematopoietic Precursor-Derived Myeloid Intermediates Researchers found that CD34+ lung cancer stem cells co-expressed liver stem cell and myelomonocytic cell markers, showing a mixed phenotype, a combination of hepatobiliary stem/progenitor cells and myelomonocytic cells. [Stem Cells Dev] Abstract miR-491 Attenuates Cancer Stem Cells-Like Properties of Hepatocellular Carcinoma by Inhibition of GIT-1/NF-κB-Mediated EMT. Scientists showed that microRNA (miR)-491 had a negative relationship with cancer stem cell (CSC)-like properties both in cell lines and tissue samples of hepatocellular carcinoma (HCC). In HCC cell lines, nuclear factor kappa B (NF-κB)/snail pathway was involved in the epithelial to mesenchymal transition and the maintenance of CSCs-like properties. [Tumor Biol] Abstract Prolonged and Repetitive Exposure to Porphyromonas gingivalis Increases Aggressiveness of Oral Cancer Cells by Promoting Acquisition of Cancer Stem Cell Properties Repeated infection of oral cancer cells by P. gingivalis resulted in morphological changes of host cancer cells into an elongated shape, along with the decreased expression of epithelial cell markers, suggesting acquisition of an epithelial-to-mesenchymal transition phenotype. [Tumor Biol] Abstract Treatment Analysis in a Cancer Stem Cell Context Using a Tumor Growth Model Based on Cellular Automata A cellular automata model based on the presence of hallmarks in the cells, which includes a simulation of the behavior of cancer stem cells and their implications for the resultant growth behavior of the multicellular system, was employed. This modeling of cancer growth, in the avascular phase, was employed to analyze the effect of cancer treatments in a cancer stem cell context. [PLoS One] Full Article Different Effects of BORIS/CTCFL on Stemness Gene Expression, Sphere Formation and Cell Survival in Epithelial Cancer Stem Cells Researchers studied the role of BORIS (brother of regulator of imprinted sites) in epithelial tumor cells. Using BORIS-molecular beacon that was already validated, they were able to show the presence of BORIS mRNA in cancer stem cell-enriched populations (side population and spheres) of cervical, colon and breast tumor cells. [PLoS One] Full Article A Pivotal Role of Krüppel-Like Factor 5 in Regulation of Cancer Stem-Like Cells in Hepatocellular Carcinoma Krüppel-like factor 5 (KLF5) overexpression enriched the CD44High/CD133High subpopulation and, consistent with the up-regulation of CD44High/CD133High, KLF5 overexpressing cells were more resistant to anti-cancer drugs and displayed enhanced colony-formation capacity. [Cancer Biol Ther] Abstract Regulation of Stem Cells-Related Signaling Pathways in Response to Doxorubicin Treatment in Hs578T Triple-Negative Breast Cancer Cells The authors investigated the cellular and molecular signaling of two claudin-low triple-negative breast cancer cells to doxorubicin and docetaxel treatment. While the treatment reduced the proliferation, aggregation and mammosphere forming ability of stem-like cells derived from Hs578T cell line, stem-like cells derived from MDA-MB-231 cells were not significantly affected. [Mol Cell Biochem] Abstract |