Suppression of Intestinal Tumors by Targeting the Mitotic Spindle of Intestinal Stem Cells Using organoid cultures established from conditional knockout mice and in vitro gene ablation, the authors showed that adenomatous polyposis coli inactivation led to aberrant intestinal stem cells proliferation and the expansion of the crypt domain. [Oncogene] Abstract All-Trans Retinoic Acid Targets Gastric Cancer Stem Cells and Inhibits Patient-Derived Gastric Carcinoma Tumor Growth Investigators evaluated the effects of all-trans-retinoic acid (ATRA) on cancer stem cells in human gastric carcinoma. ATRA effects were evaluated on the proliferation and tumorigenic properties of gastric carcinoma cells from patient-derived tumors and cell lines in conventional 2D cultures, in 3D culture systems and in mouse xenograft models. [Oncogene] Abstract Cancer Stem Cell-Secreted Macrophage Migration Inhibitory Factor Stimulates Myeloid Derived Suppressor Cell Function and Facilitates Glioblastoma Immune Evasion Investigators have identified immune-suppressive myeloid-derived suppressor cells (MDSCs) in the brains of glioblastoma patients and found that they were in close proximity to self-renewing cancer stem cells. MDSCs were selectively depleted using 5-flurouracil in a low-dose administration paradigm, which resulted in prolonged survival in a syngeneic mouse model of glioma. [Stem Cells] Abstract Effective Elimination of Liver Cancer Stem-Like Cells by CD90 Antibody Targeted Thermosensitive Magnetoliposomes The authors aimed to investigate the use of thermosensitive magnetoliposomes loaded with magnetic iron oxide and the anti-cancer stem cell marker CD90 to target and kill CD90+ liver cancer stem cells. [Oncotarget] Full Article Cisplatin Induces Stemness in Ovarian Cancer Researchers utilized a GFP reporter driven by the NANOG-promoter to enrich and track ovarian cancer stem cells (CSCs). Using this approach, they identified a population of cells with CSC properties including enhanced expression of stem cell transcription factors, self-renewal, and tumor initiation. [Oncotarget] Full Article Non-Tumor Tissue Derived Interleukin-17B Activates IL-17RB/AKT/β-Catenin Pathway to Enhance the Stemness of Gastric Cancer The authors confirmed that the expression of interleukin-17 receptor B (IL-17RB) in gastric cancer tissues was significantly increased, that overexpression was associated with poor prognosis of gastric cancer patients, and that overexpression was positively correlated with some stemness markers. Exogenous rIL-17B significantly promoted the stemness of gastric cancer cells depending on IL-17RB and induced the expression of IL-17RB. [Sci Rep] Full Article Identification of CD90 as Putative Cancer Stem Cell Marker and Therapeutic Target in Insulinomas Researchers characterized and targeted putative malignant insulinoma (INS) cancer stem cells. Using fluorescence-activated cell sorting, human INS cell line CM and pancreatic carcinoid cell line BON1 were screened for the presence of stem cell-associated markers. [Stem Cells Dev] Abstract Bone Microenvironment-Mediated Resistance of Cancer Cells to Bisphosphonates and Impact on Bone Osteocytes/Stem Cells Scientist provide insights into the interplay between cancer stem cells and osteocytes/osteoblasts and mesenchymal stem cells using a three-dimensional live cancer-bone interactive model. [Clin Exp Metastasis] Abstract Associations between Markers of Colorectal Cancer Stem Cells, Mutation, miRNA and the Clinical Features of Ulcerative Colitis Researchers investigated markers of cancer cell pluripotency, including CD44 and CD166, microRNA-21 and microRNA-215, and APC, K-ras and DCC mutations in biopsy specimens from patients with ulcerative colitis to evaluate any correlations with clinical risk factors. [Colorectal Dis] Abstract |