|Cancer Stem Cell News 6.07 February 22, 2017|
Investigators report that hTERThigh prostate cancer cells exhibit cancer stem-like cell properties, including a stem cell-associated gene expression signature, long term tumor-propagating capacity and epithelial-to-mensenchymal transition. [Cancer Res]
Scientists investigated the interactions between cancer stem cells (CSCs) and cancer associated fibroblasts (CAFs) in mammary gland tumors driven by combined activation of Wnt/β-catenin and Hgf/Met signaling in mouse mammary epithelial cells. In this setting, CSCs secreted the hedgehog ligand SHH, which regulated CAFs via paracrine activation of Hedgehog signaling. [Cancer Res]
Researchers identified a highly tumorigenic cancer stem cell population in a mouse model of transitional epithelial carcinoma and uncovered a mechanism by which loss of TGFβ receptor II mediates invasion and metastasis through de-repression of ELMO1, a RAC-activating guanine exchange factor, specifically in cancer stem cells of transition zone tumors. [eLife]
The authors found that chemotherapy induces the expression of glutathione S-transferase omega 1 (GSTO1), which is dependent on hypoxia-inducible factor (HIF)-1 and HIF-2. Knockdown of GSTO1 expression abrogated carboplatin-induced breast cancer stem cells enrichment, decreased tumor initiation and metastatic capacity, and delayed tumor recurrence after chemotherapy. [Cell Rep]
Researchers showed that stem-like traits of specific human cancer cells are reduced by overexpression of the histone deacetylase sirtuin 6 (SIRT6). Tumor metabolomic and transcriptomic analyses revealed that SIRT6 overexpression dampens phosphatidylinositol-3-kinase (PI3K) signaling and stem-like characteristics and caused metabolic rearrangements in this cancer model. [Cell Rep]
Using transcriptomic analysis of activated PIK3CA–expressing basal-like breast cancers cells, investigators identified the gene encoding the humoral pattern recognition molecule pentraxin-3 as a critical target of oncogenic phosphoinositide 3-kinase (PI3K) signaling. [Sci Signal]
Scientists screened the expression of homeobox genes in mammary stem cells to establish their role in stem cell transformation in breast cancer. They demonstrated altered expression of homeobox genes in breast cancer stem/progenitor cells. HOXC8 was consistently downregulated in stem/progenitor cells of all breast molecular subtypes, thus representing a tumor suppressor candidate. [Mol Cancer]
In order to understand how Cdk5 inhibition affects tumorsphere formation, researchers identified a role of Cdk5 in detachment-induced cell death: Cdk5 inhibition induced apoptosis in tumorspheres by stabilizing the transcription factor Foxo1 which results in increased levels of the pro-apoptotic protein Bim. [Br J Cancer]
The authors generated two tumor tissue-derived breast cancer stem cell (BCSC) lines that showed prolonged maintenance over 20 serial passages in vitro, while retaining their tumor-initiating biological properties. They found that inhibition of pro-opiomelanocortin (POMC) attenuates phosphorylation of AKT2 and GSK3β in BCSC. [Int J Cancer]
A rapid and high-sensitivity approach for circulating tumor cells (CTCs) detection using an integrated microfluidic system, consisting of a deterministic lateral displacement isolating structure, an automatic purifying device with CD45-labeled immunomagnetic beads and a capturing platform coated with rat-tail collagen was reported. [Sci Rep]
Scientists examined the roles of contractile dynamics of cancer stem like cells (CSCs) in cell invasion and delineated the underlying molecular mechanisms of their distinct cell invasion potential. Using de-adhesion assay and atomic force microscopy, they showed that CSCs derived from melanoma and breast cancer cell lines exhibit increased contractility compared to non-CSCs across all tumor types. [Oncotarget]
The authors review the recent advances in cancer stem cells and autophagy, analyze the complex relationship between them, and hope to apply this new knowledge to the strategies for anticancer therapy. [Cancer Lett]
Researchers discuss the latest developments in isolation and culturing approaches of tumor-initiating cells (TICs), with focus on colorectal cancer. [Mol Cancer]
Visit our reviews page to see a complete list of reviews in the cancer stem cell research field.
Boston Biomedical has initiated dosing of the first patient in a new global Phase III study, CanStem111P. The study will investigate napabucasin – an orally administered, first-in-class, investigational agent designed to inhibit cancer stemness pathways by targeting STAT3 – in combination with standard of care in patients with metastatic pancreatic cancer. [Boston Biomedical]
Cellectar Biosciences, Inc. announced the successful completion of Cohort 3 and initiation of Cohort 4 in the company’s Phase I clinical study of CLR 131 in patients with relapsed and refractory multiple myeloma. [Cellectar Biosciences, Inc.]
At least two dozen junior and senior researchers are stuck in scientific limbo after being barred from publishing data collected over a 25-year period at a National Institutes of Health (NIH) lab. The unusual ban follows the firing last summer of veteran neurologist Allen Braun by the National Institute on Deafness and Other Communication Disorders for what many scientists have told Science are relatively minor, if widespread, violations of his lab’s experimental protocol. [ScienceInsider]
A consortium of academic institutes near Paris is hoping to lure British universities to create research campuses in France, dangling as bait the possibility of access to European Union research funds after Brexit. [Nature News]
NEW 2nd Global Cancer Summit 2017
NEW 2nd International Conference on Stem Cells
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