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Pulmonary Cell News| Cancer Stem Cell News 6.16 April 26, 2017 | |
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TOP STORYThrough proteomic analysis of the MSI2-interacting RNA-binding protein network and functional shRNA screening, researchers identified 24 genes required for in vivo leukemia. Syncrip was the most differentially required gene between normal and myeloid leukemia cells. SYNCRIP depletion increased apoptosis and differentiation while delaying leukemogenesis. [Nat Genet] Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)The authors found that the growth factor HGF promotes cancer stem-like cell (CSC) sphere formation in non-small cell lung cancer cell populations. In patient-derived sphere-forming assays with HGF, CD49f and CD104 were defined as novel markers of lung CSC. [Cancer Res] Abstract Spheroids derived from single polyploid giant cancer cells (PGCCs) grew into a wide spectrum of human neoplasms, including germ cell tumors, high-grade and low-grade carcinomas and benign tissues. Daughter cells derived from PGCCs showed attenuated capacity for invasion and increased resistance to paclitaxel. [Oncogene] Full Article Investigators estimated the potentiality of Cripto-1 (CR-1) as an esophageal squamous cell carcinoma (ESCC) cancer stem-like cells surface marker and investigated the clinical significance of CR-1 expression in ESCC. [Mol Cancer] Full Article Scientists found that depletion of β-Arrestin1 extended the population doubling time and the percentage of senile cells, the signatures of cellular senescence, of leukemia-initiating cells of B-lineage acute lymphoblastic leukemia (B-ALL LICs). Moreover, lack of β-Arrestin1 enhanced the expression of proteins and genes related to senescence in leukemic Reh cells and B-ALL-LICs-derived leukemic mice. [Cell Death Dis] Full Article CRB3 Downregulation Confers Breast Cancer Stem Cell Traits through TAZ/β-Catenin Researchers detected significantly lower or negative crumbs homolog 3 (CRB3) expression in human breast cancer tissues. Knockdown of CRB3 generated non-tumorigenic, immortalized breast epithelial cell line MCF 10A with cancer stem cell properties. [Oncogenesis] Full Article Endothelium Originated from Colorectal Cancer Stem Cells Constitute Cancer Blood Vessels Investigators showed that cancer stem cells of human colorectal carcinomas (CoCSCs) can give rise to vascular endothelial cells and compose the vasculatures in cancer tissues. The human-cell-specific nuclear antigen NuMA+ vascular endothelial cells were detected in the blood vessels in xenografts derived from CoCSCs. [Cancer Sci] Abstract Researchers provide the features of circulating gastric cancer stem cells (CGCSCs) isolated from human gastric adenocarcinoma. The CGCSCs and tissue gastric cancer stem cells were cultured in the same serum free stem cell culture medium, however their morphology were different from each other. [J Cancer Res Clin Oncol] Abstract miR-196a-5p Modulates Gastric Cancer Stem Cell Characteristics by Targeting Smad4 The authors analyzed the miRNA expression profiles regulating the cancer stem-like cell characteristics in gastric cancer. Gastric cancer stem cells were sorted using the stem cell marker CD44 by fluorescence-activated cell sorting. [Int J Oncol] Abstract Investigators determined the molecular mechanisms of secretory phospholipase A2 group IIa (sPLA2-IIa) in stimulating HER/ERBB-elicited signaling and supporting cancer stem cell properties. They found that sPLA2-IIa binds both EGFR and HER3 demonstrated by co-immunoprecipitation experiments and also indirectly interacts with HER2, suggesting that sPLA2-IIa functions as a ligand for both EGFR and HER3. [Int J Oncol] Abstract | |
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REVIEWSNanomedicine-Mediated Drug Targeting of Cancer Stem Cells The authors highlight the use of nanomedicine-mediated dual drug delivery to target cancer stem cells and bulk cancer cells simultaneously. They also summarize current prospects and challenges associated with this therapy. [Drug Discov Today] Abstract Scientists discuss the long non-coding RNAs (lncRNAs) that have been associated with the epithelial-mesenchymal transition (EMT) process in cancer and the variety of molecular mechanisms and signaling pathways through which they regulate EMT, and finally discuss how these EMT-regulating lncRNAs impact on both anti-cancer drug resistance and the cancer stem cell phenotype. [Cancers] Full Article Visit our reviews page to see a complete list of reviews in the cancer stem cell research field. | |
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INDUSTRY NEWSPfizer Inc. announced that the Committee for Medicinal Products for Human Use (CHMP) of the European Medicines Agency has adopted a positive opinion recommending approval of BESPONSA® in the European Union as monotherapy for the treatment of adults with relapsed or refractory CD22-positive B-cell precursor Philadelphia chromosome negative (Ph–) acute lymphoblastic leukemia (ALL) and Ph+ ALL, who have previously failed treatment with at least one tyrosine kinase inhibitor. [Pfizer Inc.] Press Release Stony Brook University Gala Raises More Than $6.9 Million for Cancer Research and Scholarships The University raised $6,946,000 in gifts and pledges including $2,051,000 for scholarships and $4,895,000 to support the Stony Brook University Cancer Center. [Stony Brook University] Press Release | |
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POLICY NEWSCalifornia’s $3-Billion Bet on Stem Cells Faces Final Test When California voters approved US$3 billion in funding for stem-cell research in 2004, biologists flocked to the state, and citizens dreamed of cures for Parkinson’s disease and spinal-cord injuries. Now, the pot of money — one of the biggest state investments in science — is running dry before treatments have emerged, raising questions about whether Californians will pour billions more into stem-cell research. [Nature News] Editorial NSF’s Uphill Road to Making Prestigious Early Career Award More Diverse Only five women have won the National Science Foundation’s (NSF) annual Alan T. Waterman Award in its 41-year history, and no woman of color has ever been selected. The 2017 winners announced this month mark the 13th year in a row that the $1 million research prize has gone to a man (two, actually, including the second black scientist ever chosen.) [ScienceInsider] Editorial The Broad Institute Is Testing the Limits of What ‘Nonprofit’ Means When a federal patent court ruled that the nonprofit Broad Institute of MIT and Harvard could legally license its version of the CRISPR-Cas9 genome-editing system, it opened the door to millions of dollars of revenue for the institute. It also contributed to the seismic shift occurring in science whereby tax-exempt research institutes established under an emerging model of “free market philanthropy” can amass money to further their research and protect their commercial interests. [STAT News] Editorial Cancer Institute Reinstates Director after Uproar from Staff and Funder Eight days after learning via email that she was no longer the head of the Huntsman Cancer Institute in Salt Lake City, cell biologist Mary Beckerle has been invited to reassume her position. The announcement from University of Utah President David Pershing seeks to smooth a tense relationship between the semiautonomous center, its main philanthropic funder and the university that houses it. [ScienceInsider] Editorial ‘Boffins and Their VERY Academic Chants’: How the Media Covered the March for Science “What do we want? Evidence-based policy. When do we want it? After peer review.” That slogan was a source of amusement for the U.K. tabloid The Daily Mail. “Boffins’ VERY academic chant as Doctor Who joins thousands protesting against Brexit during global March for Science,” the paper headlined its story about the march. [ScienceInsider] Editorial
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EVENTSNEW Gordon Research Conferences: Cancer Nanotechnology Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESPostdoctoral Fellows – Cancer Stem Cell Biology (Genome Institute of Singapore) Research Officers – Cancer Stem Cell Biology (Genome Institute of Singapore) Postdoctoral Fellows – Cancer Biology (University of Texas Medical School at Houston) Postdoctoral Positions – Epigenetics, Stem Cells and Cancer (University of Copenhagen) Postdoctoral Fellow – Breast Cancer Stem Cell (University of Kentucky) Postdoctoral Position – Stem Cell Research (Helmholtz Association) Postdoctoral Fellow – Breast Cancer (Tufts University School of Medicine) Postdoctoral Fellow – Cell Cycle Control and Tumorigenesis (Fred Hutchinson Cancer Research Center) Postdoctoral Fellow – Ubiquitin System and Cancer (Fred Hutchinson Cancer Research Center) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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