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Pulmonary Cell News| Cancer Stem Cell News 6.23 June 14, 2017 | |
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TOP STORYIntegrin α7 Is a Functional Marker and Potential Therapeutic Target in Glioblastoma In vitro and in vivo analyses showed that integrin α7 (ITGA7) plays a key functional role in growth and invasiveness of glioblastoma stem-like cells. They also found that targeting of ITGA7 by RNAi or blocking mAbs impaired laminin-induced signaling, and it led to a significant delay in tumor engraftment plus a strong reduction in tumor size and invasion. [Cell Stem Cell] Abstract | Graphical Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)Investigators showed that chronic phase chronic myelogenous leukemia (CP-CML), blast crisis-CML, and acute myeloid leukemia stem cells upregulate MHCII in allogeneic hematopoietic stem cell transplantation recipients. [J Clin Invest] Full Article Researchers addressed the effects of the pharmacological inhibition of hypoxia-inducible factor-1 (HIF-1), a critical regulator of leukemia stem cell survival, on the maintenance of chronic myeloid leukemia (CML) stem cell potential. They found that the HIF-1 inhibitor acriflavine decreased survival and growth of CML cells. [Blood] Abstract Scientists showed that anti-progastrin antibodies decrease self-renewal of CSCs both in vitro and in vivo, either alone or in combination with chemotherapy. Furthermore, migration and invasion of CRC cells are diminished; chemosensitivity is prolonged in SW620 and HT29 cells and post-treatment relapse is significantly delayed in T84 cells, xenografted nude mice. [Clin Cancer Res] Abstract EMP2 Is a Novel Therapeutic Target for Endometrial Cancer Stem Cells To understand the role of epithelial membrane protein-2 (EMP2) in the etiology of disease, gene analysis was performed to show transcripts that are reciprocally regulated by EMP2 levels. In particular, EMP2 expression correlated with and helped to regulate the expression of several cancer stem cell associated markers including aldehyde dehydrogenase 1. [Oncogene] Abstract The authors used single cell cloning to isolate and characterize four isogenic cell clones from a triple-negative breast cancer cell line; two exhibited mesenchymal-like and two epithelial-like characteristics. Within these pairs, one, but not the other, resulted in tumors in immunodeficient NOG mice and efficiently formed mammospheres. [Stem Cells] Abstract Scientists report a potential solution to these issues that involves a type of novel multifunctional vinblastine liposomes equipped with transferrin receptor binding peptide TfR-T12 and octa-arginine conjugate stearyl-R8. Studies were performed on brain glioma and glioma stem cells in vitro and were verified in brain glioma-bearing mice. [Sci Rep] Full Article Investigators provide evidence that the mitochondrial nicotinamide adenine dinucleotide (NAD)+ levels affect the characteristics of glioma-driven SSEA1+ tumor-initiating cells, including clonogenic growth potential. [Exp Mol Med] Full Article Nectin-4 Is a Breast Cancer Stem Cell Marker that Induces WNT/β-Catenin Signaling via Pi3k/Akt Axis Using the breast cancer metastasis model system, scientists revealed that Nectin-4 is a marker for breast cancer stem cells (BCSCs) and provide experimental evidence suggesting that it utilizes WNT/β-Catenin signaling via Pi3k/Akt axis for self renewal of BCSCs. [Int J Biochem Cell Biol] Abstract The authors investigated the inhibitory effect of A. cinnamomea mycelium and extract on cancer stem cells derived from various human cancer cell lines using their in-house therapeutics and human genome-wide miRNA screening panels. [J Ethnopharmacol] Abstract | |
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REVIEWSAs regenerative stem cells (RSCs) are known for their trophic effects, anti-tumorogenicity and better migration towards an injury site, this review aims to address the use of adult stem cells such as dental pulp derived; cord blood derived pure populations of regenerative stem cells for targeting CSCs. [J Cell Biochem] Abstract Visit our reviews page to see a complete list of reviews in the cancer stem cell research field. | |
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INDUSTRY NEWSNantKwest and Nantworks announced the expansion of the company’s existing NANT Cancer Vaccine program in pancreatic cancer to target a number of additional tumor types. [NantKwest] Press Release DanDrit Biotech Announces New Therapeutic Research Strategy DanDrit Biotech USA, Inc. announced that Mr. Rene Sindlev and Mr. Torben Bjørn Christensen joined DanDrit’s Board of Directors as part of a new strategy to expand the company’s focus beyond its ongoing clinical drug trials to develop new therapeutic programs to treat cancer and other serious diseases. [DanDrit Biotech USA, Inc.] Press Release | |
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POLICY NEWSTrump Names Sharpless to Lead U.S. Cancer Institute President Donald Trump announced his intention to appoint Norman “Ned” Sharpless to be the next director of the National Cancer Institute in Bethesda, Maryland. Sharpless, who is 50 years old, is a physician and currently director of the Lineberger Comprehensive Cancer Center at the University of North Carolina in Chapel Hill. He also holds an academic appointment at the university’s school of medicine. [ScienceInsider] Editorial Empty Rhetoric over Data Sharing Slows Science Government agencies lack the funds to build platforms for data sharing and resist taking responsibility for such infrastructure. They may hope that universities will host data, but the development of institutional repositories is patchy, and to rely on them is effectively to discourage common data standards and curation. [Nature News] Editorial Can Fake Names Tease Out NIH Reviewer Bias? When the label “white male” is attached to a research grant application, do peer reviewers give it a better score? That’s the question psychologist Patricia Devine of the University of Wisconsin in Madison has spent the past four years, and more than $1 million from the National Institutes of Health (NIH) in Bethesda, Maryland, trying to answer with an unusual experiment. [ScienceInsider] Editorial Curiosity and Irritation Meet Macron’s Effort to Lure Foreign Scientists to France The French government unveiled a website aimed at attracting foreign scientists with four-year grants worth up to €1.5 million each. [ScienceInsider] Editorial
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EVENTSNEW Advances in Modeling Cancer in Mice: Technology, Biology, and Beyond Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Postdoctoral Position – Cancer Biology (UCLA) Postdoctoral Scholar – Cancer Research (UCLA G.O. Discovery Laboratory) Postdoctoral Fellow – Stem Cell Biology and Epigenetics (University of South Carolina) Professor – Stem Cell Biology (University College London) Postdoctoral Fellow – Cancer Biology (Case Western Reserve University) Postdoctoral Positions – Cancer Biology (University of Minnesota) Faculty Positions – Cancer and Stem Cell Biology (Sun Yat-Sen University) Postdoctoral Associate – Cancer Biology/Immunology/Leukemia Research (University of Miami) Postdoctoral Associate – Cancer Research/Oncology (University of Miami) Postdoctoral Fellows – Cancer Stem Cell Biology (Genome Institute of Singapore) Research Officers – Cancer Stem Cell Biology (Genome Institute of Singapore) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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