|Cancer Stem Cell News 6.42 October 25, 2017|
Through NOD.Cg-PrkdcscidIl2rgtmlWjl/Sz xenotransplantation, researchers functionally identified preleukemic and leukemic stem cell populations present in FMS-like tyrosine kinase 3 internal tandem duplication–positive acute myeloid leukemia patient samples. [Sci Transl Med]
Scientists showed that BCL-XL expression is selectively advantageous to cancer cell populations even in the absence of pro-apoptotic pressure. In transformed human mammary epithelial cells BCL-XL favored full activation of signaling downstream of constitutively active RAS with which it interacts in a BH4-dependent manner. [Nat Commun]
The authors demonstrated that miR-31 promotes mammary epithelial proliferation and mammary stem cell expansion at the expense of differentiation in vivo. Loss of miR-31 compromised mammary tumor growth, reduced the number of cancer stem cells, as well as decreased tumor-initiating ability and metastasis to the lung, supporting its pro-oncogenic function. [Nat Commun]
Microarray analyses were used to identify invasion-related genes in J3T-2 cells, and the expressed genes and their intracellular and intratumoral distribution patterns were evaluated in J3T-2 cell lines, human glioma cell lines, human glioblastoma stem cells and human glioblastoma specimens. [Oncogene]
The authors demonstrated the capacities of the non-saponin fraction of P. ginseng and its active principle panaxynol to inhibit Hsp90 function and viability of both non-CSC and CSC populations of non-small-cell lung carcinoma in vitro and in vivo. [Cancer Lett]
Researchers showed that by carefully modulating the amphiphilic nature of a monoamine-based glycosylated antitumor ether lipid, they can generate a potent triamino scaffold that is active against a panel of hard-to-kill epithelial cancer cell lines and BT474 CSCs. [J Med Chem]
Investigators elucidated the relationship between CSC hierarchies and chemoresistance in an ovarian cancer model. Using a single cell-based approach to CSC discovery and validation, they report a novel, four-component CSC hierarchy based around the markers cluster of differentiation 10 and aldehyde dehydrogenase. [Cell Death Dis]
Scientists investigated the expression of CD44, CD24 and ALDH1 in different subtypes of breast cancer cells, and explored their relationship with cancer progression. They defined a parameter CD44/CD24 ratio to present the expression level of CD44 and CD24 and found that high CD44/CD24 ratio and ALDH1+ are both indicators for cancer malignancy, but play different functions during tumor progression. [Sci Rep]
The authors studied and functionally characterized acid sensing ion channels (ASICs) in two primary glioblastoma stem cell lines as cell culture models. They detected transcripts of the ACCN2 and ACCN3 genes, coding for ASIC1 and ASIC3, respectively, but not transcripts of ACCN1. [Sci Rep]
Controlling the geometry at the interface of a population of melanoma cells reveals a role for perimeter topology in promoting a stem-like state with enhanced tumorigenicity. Investigators showed that this putative melanoma-initiating cell (MIC) demonstrates significant enhancement in the secretion of proangiogenic molecules. This finding suggests the possibility of an “invasive niche” at the perimeter of a growing tumor that promotes a MIC state with angiogenic activity. [Sci Adv]
MiRNA and small-molecule targeted therapies have emerged as a potential new therapeutic paradigm in medulloblastoma treatment. However, the development of chemoresistance due to surviving cancer stem cells and dysregulation of miRNAs remains a challenge. [Trends Pharmacol Sci]
Colorectal cancer stem cells are responsible for the initiation, progression and metastasis of human colorectal cancers, and have been characterized by the expression of cell surface markers, such as CD44, CD133, CD166 and LGR5. MicroRNAs are differentially expressed between CSCs and non-tumorigenic cancer cells, and play important roles in the maintenance and regulation of stem cell properties of CSCs. [Cancers]
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AbbVie and Harpoon Therapeutics announced that they have entered an immuno-oncology research collaboration. [AbbVie, Inc.]
Actinium Pharmaceuticals, Inc. announced that the company has successfully activated fifteen clinical trial sites in the pivotal Phase III SIERRA (Study of Iomab-B in Elderly Relapsed or Refractory Acute Myeloid Leukemia) trial. [Actinium Pharmaceuticals, Inc.]
The Association of American Medical Colleges and three allied groups are pushing for sweeping changes to animal research rules. In a report, the groups call for moving all oversight to a single, unnamed agency, conducting less frequent lab inspections, and giving researchers greater say in crafting new rules. [ScienceInsider]
A group of French scientists is due to meet government officials in a bid to resolve a row that has left many of the country’s leading biomedical researchers furious. Scientists were shocked when the government unexpectedly postponed a call for applications to create a new crop of medical-research clusters just days before the closing date, and said that it would slash the budget earmarked for the project. [Nature News]
A judge in Tehran has ordered the death penalty for Iranian researcher Ahmadreza Djalali, according to his wife and diplomatic sources in Italy. Djalali is affiliated with the Karolinska Institute in Stockholm, Sweden, and the University of Eastern Piedmont in Novara, Italy. A resident of Sweden with his family, Djalali was arrested in April 2016 on an academic visit to Tehran and accused of “collaboration with a hostile government”. [Nature News]
With time and money running out, Brazilian scientists are turning up the pressure on the federal government to avoid a total collapse of the national science and technology funding system before the end of the year. Researchers delivered a petition with more than 82,000 signatures to congressional leaders in Brasília, demanding the reversal of deep budget cuts that have left research institutions struggling to pay even basic water and electricity bills. [ScienceInsider]
NEW 37th World Congress of Hematology (ISH)
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