Cancer Stem Cell News Volume 7.04 | Jan 31 2018

TOP STORY

CD10⁺GPR77⁺ Cancer-Associated Fibroblasts Promote Cancer Formation and Chemoresistance by Sustaining Cancer Stemness

Scientists demonstrated that two cell-surface molecules, CD10 and GPR77, specifically define a carcinoma-associated fibroblast (CAF) subset correlated with chemoresistance and poor survival in multiple cohorts of breast and lung cancer patients. CD10⁺GPR77⁺ CAFs promoted tumor formation and chemoresistance by providing a survival niche for CSCs. [Cell] Abstract | Graphical Abstract

(Ranked by impact factor of the journal)

Ring1A and Ring 1B Inhibit Expression of Glis2 to Maintain Murine MOZ-TIF2 AML Stem Cells

In a mouse model of acute myelogenous leukemia (AML) expressing the MOZ-TIF2 fusion, the authors found that Ring1A and Ring1B, components of Polycomb repressive complex 1, play crucial roles in maintaining AML stem cells. [Blood] Abstract

Identification of Tumor Initiating Cells by a Small Molecule Fluorescent Probe through Vimentin as the Biomarker

Investigators report the first tumor initiating cell (TIC)-specific fluorescent chemical probe, TiY, with the identification of the molecular target as vimentin, a marker for epithelial-to-mesenchymal transition. [Angew Chem Int Ed Engl] Abstract

MicroRNA-508 Defines the Stem-Like/Mesenchymal Subtype in Colorectal Cancer

In clinical colorectal cancer specimens, expression of miRNA-508 negatively correlated with stemness and epithelial-mesenchymal transition-associated gene expression and inversely correlated with patient survival. [Cancer Res] Abstract

The Antigen ASB4 on Cancer Stem Cells Serves as a Target for CTL Immunotherapy of Colorectal Cancer

Investigators conducted an HLA ligandome analysis to survey HLA-A24 peptides displayed by CSCs and non-CSCs of colorectal cancer. [Cancer Immunol Res] Abstract | Full Article

Aggressive Serous Epithelial Ovarian Cancer Is Potentially Propagated by EpCAM⁺CD45⁺ Phenotype

Scientists found that the entire EpCAM⁺CD45⁺ population is highly invasive with signature mesenchymal gene expression and also consists of subpopulations of ovarian CSCs. [Oncogene] Abstract

Downregulation of Annexin A3 Inhibits Tumor Metastasis and Decreases Drug Resistance in Breast Cancer

Investigators found that annexin A3 knockdown inhibited the NFκB pathway via upregulating IκBα, resulting in mesenchymal–epithelial transition and a heterogeneity change of breast CSCs. [Cell Death Dis] Full Article

Depletion of HDAC1, 7 and 8 by Histone Deacetylase Inhibition Confers Elimination of Pancreatic Cancer Stem Cells in Combination with Gemcitabine

The authors evaluated the effect of trichostatin A on histone deacetylase (HDAC) expression, tumor cell proliferation, and CSC activities in pancreatic ductal adenocarnoma cells. [Sci Rep] Full Article

Blockade of ACK1/TNK2 to Squelch the Survival of Prostate Cancer Stem-Like Cells

To uncover tyrosine kinase/s critical for the survival of the CD44⁺PSA^−/lo subpopulation, researchers performed an unbiased screen targeting 87 tyrosine kinases with gene specific siRNAs. Among a subset of tyrosine kinases crucial for prostate cancer stem-like cell survival, was a non-receptor tyrosine kinase, ACK1/TNK2, a critical regulator of castration resistant prostate cancer growth. [Sci Rep] Full Article

The Ever-Evolving Concept of the Cancer Stem Cell in Pancreatic Cancer

The authors provide the latest updates and knowledge on the inherent characteristics of pancreatic CSCs, particularly their unique biological properties including chemoresistance, epithelial to mesenchymal transition, plasticity, metabolism and autophagy. [Cancers] Full Article

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Diffusion Pharmaceuticals Announces First Patient Dosed in Phase III Trial with TSC in Inoperable Glioblastoma Multiforme

Diffusion Pharmaceuticals Inc. announced that the first patient has been dosed in the company’s Phase III clinical trial with trans sodium crocetinate (TSC) in patients with newly-diagnosed inoperable glioblastoma multiforme. [Diffusion Pharmaceuticals Inc.] Press Release

Amgen Receives CHMP Positive Opinion to Add Updated Overall Survival Data to KYPROLIS^® (Carfilzomib) Label

Amgen announced that the Committee for Medicinal Products for Human Use (CHMP) of the European Medicines Agency has adopted a positive opinion recommending a label variation for KYPROLIS^® to include updated overall survival data from the Phase III head-to-head ENDEAVOR trial in patients with relapsed or refractory multiple myeloma. [Amgen] Press Release

US Government Rethinks How to Retire Research Chimps

The research chimpanzees owned or supported by the US National Institutes of Health are ready to retire — but nearly 300 are still stuck in 3 US research facilities, awaiting spots at the country’s only federally funded sanctuary. [Nature News] Editorial

Computer Scientist to Lead French Research Giant; Interim Head Leaves Amid Misconduct Allegations

Computer scientist Antoine Petit, 57, is the new head of Europe’s largest research organization. There was an unusual twist to Petit’s appointment, however. A week before the official procedure ended, the French government named Petit interim president of the National Center for Scientific Research, a position that had been held by cell biologist Anne Peyroche since Fuchs’s departure. [ScienceInsider] Editorial

NEW Advances in Cell and Tissue Culture (ACTC) 2018
May 21-23, 2018
Cardiff, United Kingdom

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NEW Postdoctoral Fellow – Cancer Biology (Johns Hopkins University)

Postdoctoral Fellow – Cancer Stem Cell Biology (Wake Forest Baptist Comprehensive Cancer Center)

Postdoctoral Associate – Cerebral Organoids and Tumor Stem Cell Biology (Weill Cornell Medicine)

Postdoctoral Scholarship – Translational Cancer Stem Cell Biology (Lund University)

Postdoctoral Positions – Gene Regulation and/or Cancer Biology (University of North Carolina)

Postdoctoral Fellow – Cancer Biology (University of Pennsylvania)

Postdoctoral Associate – Control of Metastasis/Cancer Stem Cell Regulation (University of Miami)

Faculty Positions – Cancer and Stem Cell Biology (Sun Yat-Sen University)

Postdoctoral Fellows – Cancer Stem Cell Biology (Genome Institute of Singapore)

Research Officers – Cancer Stem Cell Biology (Genome Institute of Singapore)

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