|Cancer Stem Cell News 7.04 January 31, 2018|
Scientists demonstrated that two cell-surface molecules, CD10 and GPR77, specifically define a carcinoma-associated fibroblast (CAF) subset correlated with chemoresistance and poor survival in multiple cohorts of breast and lung cancer patients. CD10+GPR77+ CAFs promoted tumor formation and chemoresistance by providing a survival niche for CSCs. [Cell]
In a mouse model of acute myelogenous leukemia (AML) expressing the MOZ-TIF2 fusion, the authors found that Ring1A and Ring1B, components of Polycomb repressive complex 1, play crucial roles in maintaining AML stem cells. [Blood]
Investigators report the first tumor initiating cell (TIC)-specific fluorescent chemical probe, TiY, with the identification of the molecular target as vimentin, a marker for epithelial-to-mesenchymal transition. [Angew Chem Int Ed Engl]
In clinical colorectal cancer specimens, expression of miRNA-508 negatively correlated with stemness and epithelial-mesenchymal transition-associated gene expression and inversely correlated with patient survival. [Cancer Res]
Investigators conducted an HLA ligandome analysis to survey HLA-A24 peptides displayed by CSCs and non-CSCs of colorectal cancer. [Cancer Immunol Res]
Scientists found that the entire EpCAM+CD45+ population is highly invasive with signature mesenchymal gene expression and also consists of subpopulations of ovarian CSCs. [Oncogene]
Investigators found that annexin A3 knockdown inhibited the NFκB pathway via upregulating IκBα, resulting in mesenchymal–epithelial transition and a heterogeneity change of breast CSCs. [Cell Death Dis]
The authors evaluated the effect of trichostatin A on histone deacetylase (HDAC) expression, tumor cell proliferation, and CSC activities in pancreatic ductal adenocarnoma cells. [Sci Rep]
To uncover tyrosine kinase/s critical for the survival of the CD44+PSA−/lo subpopulation, researchers performed an unbiased screen targeting 87 tyrosine kinases with gene specific siRNAs. Among a subset of tyrosine kinases crucial for prostate cancer stem-like cell survival, was a non-receptor tyrosine kinase, ACK1/TNK2, a critical regulator of castration resistant prostate cancer growth. [Sci Rep]
The authors provide the latest updates and knowledge on the inherent characteristics of pancreatic CSCs, particularly their unique biological properties including chemoresistance, epithelial to mesenchymal transition, plasticity, metabolism and autophagy. [Cancers]
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Diffusion Pharmaceuticals Inc. announced that the first patient has been dosed in the company’s Phase III clinical trial with trans sodium crocetinate (TSC) in patients with newly-diagnosed inoperable glioblastoma multiforme. [Diffusion Pharmaceuticals Inc.]
Amgen announced that the Committee for Medicinal Products for Human Use (CHMP) of the European Medicines Agency has adopted a positive opinion recommending a label variation for KYPROLIS® to include updated overall survival data from the Phase III head-to-head ENDEAVOR trial in patients with relapsed or refractory multiple myeloma. [Amgen]
The research chimpanzees owned or supported by the US National Institutes of Health are ready to retire — but nearly 300 are still stuck in 3 US research facilities, awaiting spots at the country’s only federally funded sanctuary. [Nature News]
Computer scientist Antoine Petit, 57, is the new head of Europe’s largest research organization. There was an unusual twist to Petit’s appointment, however. A week before the official procedure ended, the French government named Petit interim president of the National Center for Scientific Research, a position that had been held by cell biologist Anne Peyroche since Fuchs’s departure. [ScienceInsider]
NEW Advances in Cell and Tissue Culture (ACTC) 2018
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