Cancer Stem Cell News Volume 7.08 | Feb 28 2018

TOP STORY

Nuclear EGFR-PKM2 Axis Induces Cancer Stem Cell-Like Characteristics in Irradiation-Resistant Cells

Investigators found that irradiation-resistant cells exhibited increased stem cell-like properties together with elevated anchorage-independent growth and metastasis ability. EGFR not only lead to increased acquisition of endometrial cancer stem cell markers in radioresistant sublines but was critical for the cancer stem-cell phenotype and tumorigenicity. [Cancer Lett] Abstract

(Ranked by impact factor of the journal)

Transcriptional Profiles of Different States of Cancer Stem Cells in Triple-Negative Breast Cancer

Scientists used the biomarker combination of aldehyde dehydrogenase and CD24/CD44 to sort four populations isolated from triple-negative breast cancer patient-derived xenografts, and performed whole-transcriptome sequencing on each population. [Mol Cancer] Full Article

A Synthetic Binder of Breast Cancer Stem Cells

A synthetic ligand that specifically binds to CSCs over non-CSCs of breast cancer cells was identified for the first time via a cell-binding screening of a chemical library. The ligand showed specific binding to CD24⁻/CD44⁺/ALDH⁺ CSC population of MCF-7 and MDA-MB-231. [Chemistry] Abstract | Press Release

ALCAM⁺ Stromal Cells: Role in Giant Cell Tumor of Bone Progression

Investigators screened a panel of markers of normal stem cells and CSCs and found that ALCAM⁺ stromal cells possessed characteristics of stem-like cells. [Cell Death Dis] Full Article

Apoptosis Reversal Promotes Cancer Stem Cell-Like Cell Formation

The authors report that human mammary carcinoma cells induced to undergo apoptosis could recover with increased tumorigenicity in vitro and in vivo, and induced lymph node metastasis. Specifically, the reversed cells underwent epithelial-to-mesenchymal transitions in the primary tumors in situ, and mesenchymal-to-epithelial transitions in the metastatic cells. [Neoplasia] Abstract

Radiosensitization Effect of Talazoparib, a Parp Inhibitor, on Glioblastoma Stem Cells Exposed to Low and High Linear Energy Transfer Radiation

Researchers investigated the preclinical efficacy of talazoparib, a new PARP inhibitor, in association with low and high linear energy transfer irradiation in two glioblastoma cancer stem cell lines. [Sci Rep] Full Article

Scalable Culturing of Primary Human Glioblastoma Tumor-Initiating Cells with a Cell-Friendly Culture System

The authors report a new method that cultures glioblastoma tumor-initiating cells (TICs) in microscale alginate hydrogel tubes (AlgTubes). The AlgTubes allowed long-term culturing of glioblastoma TICs with high growth rate, high cell viability and high volumetric yield without losing the stem cell properties, all offered large advancements over current culturing methods. [Sci Rep] Full Article

Transcriptomic and Epigenetic Analysis of Breast Cancer Stem Cells

Transcriptomes, DNA methylomes and histone modifications were compared between CSCs and non-CSCs. Transcriptome analysis revealed several pathways that were activated in CSCs, whereas cell cycle regulation pathways were inhibited. [Epigenomics] Abstract

Untargeted Metabolomics Reveals Distinct Metabolic Reprogramming in Endothelial Cells Co-Cultured with CSC and Non-CSC Prostate Cancer Cell Subpopulations

Human umbilical vein endothelial cells were subjected to different microenvironmental conditions, such as the presence of highly metastatic PC-3M and highly invasive PC-3S prostate cancer cell lines, in addition to the angiogenic activator vascular endothelial growth factor, under normoxia. [PLoS One] Full Article

Radiation-Induced G2/M Arrest Rarely Occurred in Glioblastoma Stem-Like Cells

Researchers studied the cell-cycle alterations of glioblastoma stem-like cells (GSLCs) after irradiation, possibly enriching the mechanisms of radioresistance of GSLCs. [Int J Radiat Biol] Full Article

Recent Advances in Lgr5⁺ Stem Cell Research

The discovery of leucine-rich repeat-containing G protein-coupled receptor 5 (Lgr5) as both a marker of adult stem cells and a critical modulator of their activity via its role as an effector of Wnt/R-spondin signaling has driven major advances in the understanding of stem cell biology during homeostasis, regeneration, and disease. [Trends Cell Biol] Abstract

Visit our reviews page to see a complete list of reviews in the cancer stem cell research field.

Kite, a Gilead Company, and Sangamo Therapeutics Announce Collaboration to Develop Next-Generation Engineered Cell Therapies for the Treatment of Cancer

Kite and Sangamo Therapeutics, Inc. announced that the companies have entered into a worldwide collaboration using Sangamo’s zinc finger nuclease technology platform for the development of next-generation ex vivo cell therapies in oncology. [Sangamo Therapeutics, Inc.] Press Release

Frederick National Laboratory for Cancer Research and Georgetown University Launch Research, Education Collaboration

A new collaboration established between Georgetown University and the Frederick National Laboratory for Cancer Research aims to expand both institutions’ research and training missions in the biomedical sciences. [Georgetown University Medical Center] Press Release

Actinium Pharmaceuticals Announces Activation of Sixteenth Clinical Trial Site in the Pivotal Phase III SIERRA Trial for Iomab-B

Actinium Pharmaceuticals, Inc. announced that the company has successfully activated sixteen clinical trial sites in the pivotal Phase III SIERRA (Study of Iomab-B in Elderly Relapsed or Refractory Acute Myeloid Leukemia) trial. [Actinium Pharmaceuticals, Inc.] Press Release

Indian Scientist’s Sacking Spotlights Sexual Harassment

Female scientists in India hope that more academics will report sexual harassment without fear of jeopardizing their career or reputation, after a prominent biologist was sacked for allegedly harassing a staff member. [Nature News] Editorial

Here’s How the Scientists Running for Office Are Doing

They’re trained problem-solvers, but they have to learn to move beyond data to run successful campaigns. [The Atlantic] Editorial

Canadian Science Wins Billions in New Budget

Canadian Prime Minister Justin Trudeau’s administration released its 2018 budget and scientists couldn’t be happier. It includes almost CAD 4 billion (USD 3.1 billion) in new funding for science over the next five years, a significant portion of which will go to the country’s three granting councils. [Nature News] Editorial

Europe’s Influential Science-Policy Chief on His Successes and Disappointments

Robert-Jan Smits is about to stand down from one of the most important science-policy jobs in Europe. After eight years, he will hand over his role as director-general of the European Commission’s research directorate to Jean-Eric Paquet, currently a deputy-secretary-general at the commission. [Nature News] Editorial

NEW Case Western Reserve University: Cancer Stem Cell Conference (CSC) 2018
August 6-8, 2018
Cleveland, Ohio, United States

Visit our events page to see a complete list of events in the community.

NEW Postdoctoral Fellowship – Cell and Molecular Biology (Canadian Nuclear Laboratories)

NEW Postdoctoral Positions – Cancer Research (Memorial Sloan Kettering Cancer Center)

Bioinformatician/Senior Bioinformatician – Cancer Research (Wellcome Trust Sanger Institute)

Assistant/Associate Investigator/Professor – Gastrointestinal Cancers (Baylor Scott & White Research Institute)

Senior Bioinformatician – Cancer Research (Children´s Cancer Research Institute)

PhD Program – Cellular Biology (Institut de Génétique et de Biologie Moléculaire et Cellulaire)

Postdoctoral Fellow – Cancer Biology (Johns Hopkins University)

Postdoctoral Fellow – Cancer Stem Cell Biology (Wake Forest Baptist Comprehensive Cancer Center)

Postdoctoral Associate – Cerebral Organoids and Tumor Stem Cell Biology (Weill Cornell Medicine)

Postdoctoral Fellow – Cancer Biology (University of Pennsylvania)

Faculty Positions – Cancer and Stem Cell Biology (Sun Yat-Sen University)

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