|Cancer Stem Cell News 7.08 February 28, 2018|
Investigators found that irradiation-resistant cells exhibited increased stem cell-like properties together with elevated anchorage-independent growth and metastasis ability. EGFR not only lead to increased acquisition of endometrial cancer stem cell markers in radioresistant sublines but was critical for the cancer stem-cell phenotype and tumorigenicity. [Cancer Lett]
Scientists used the biomarker combination of aldehyde dehydrogenase and CD24/CD44 to sort four populations isolated from triple-negative breast cancer patient-derived xenografts, and performed whole-transcriptome sequencing on each population. [Mol Cancer]
A synthetic ligand that specifically binds to CSCs over non-CSCs of breast cancer cells was identified for the first time via a cell-binding screening of a chemical library. The ligand showed specific binding to CD24−/CD44+/ALDH+ CSC population of MCF-7 and MDA-MB-231. [Chemistry]
Investigators screened a panel of markers of normal stem cells and CSCs and found that ALCAM+ stromal cells possessed characteristics of stem-like cells. [Cell Death Dis]
The authors report that human mammary carcinoma cells induced to undergo apoptosis could recover with increased tumorigenicity in vitro and in vivo, and induced lymph node metastasis. Specifically, the reversed cells underwent epithelial-to-mesenchymal transitions in the primary tumors in situ, and mesenchymal-to-epithelial transitions in the metastatic cells. [Neoplasia]
Researchers investigated the preclinical efficacy of talazoparib, a new PARP inhibitor, in association with low and high linear energy transfer irradiation in two glioblastoma cancer stem cell lines. [Sci Rep]
The authors report a new method that cultures glioblastoma tumor-initiating cells (TICs) in microscale alginate hydrogel tubes (AlgTubes). The AlgTubes allowed long-term culturing of glioblastoma TICs with high growth rate, high cell viability and high volumetric yield without losing the stem cell properties, all offered large advancements over current culturing methods. [Sci Rep]
Transcriptomes, DNA methylomes and histone modifications were compared between CSCs and non-CSCs. Transcriptome analysis revealed several pathways that were activated in CSCs, whereas cell cycle regulation pathways were inhibited. [Epigenomics]
Human umbilical vein endothelial cells were subjected to different microenvironmental conditions, such as the presence of highly metastatic PC-3M and highly invasive PC-3S prostate cancer cell lines, in addition to the angiogenic activator vascular endothelial growth factor, under normoxia. [PLoS One]
Researchers studied the cell-cycle alterations of glioblastoma stem-like cells (GSLCs) after irradiation, possibly enriching the mechanisms of radioresistance of GSLCs. [Int J Radiat Biol]
The discovery of leucine-rich repeat-containing G protein-coupled receptor 5 (Lgr5) as both a marker of adult stem cells and a critical modulator of their activity via its role as an effector of Wnt/R-spondin signaling has driven major advances in the understanding of stem cell biology during homeostasis, regeneration, and disease. [Trends Cell Biol]
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Kite and Sangamo Therapeutics, Inc. announced that the companies have entered into a worldwide collaboration using Sangamo’s zinc finger nuclease technology platform for the development of next-generation ex vivo cell therapies in oncology. [Sangamo Therapeutics, Inc.]
A new collaboration established between Georgetown University and the Frederick National Laboratory for Cancer Research aims to expand both institutions’ research and training missions in the biomedical sciences. [Georgetown University Medical Center]
Actinium Pharmaceuticals, Inc. announced that the company has successfully activated sixteen clinical trial sites in the pivotal Phase III SIERRA (Study of Iomab-B in Elderly Relapsed or Refractory Acute Myeloid Leukemia) trial. [Actinium Pharmaceuticals, Inc.]
Female scientists in India hope that more academics will report sexual harassment without fear of jeopardizing their career or reputation, after a prominent biologist was sacked for allegedly harassing a staff member. [Nature News]
They’re trained problem-solvers, but they have to learn to move beyond data to run successful campaigns. [The Atlantic]
Canadian Prime Minister Justin Trudeau’s administration released its 2018 budget and scientists couldn’t be happier. It includes almost CAD 4 billion (USD 3.1 billion) in new funding for science over the next five years, a significant portion of which will go to the country’s three granting councils. [Nature News]
Robert-Jan Smits is about to stand down from one of the most important science-policy jobs in Europe. After eight years, he will hand over his role as director-general of the European Commission’s research directorate to Jean-Eric Paquet, currently a deputy-secretary-general at the commission. [Nature News]
NEW Case Western Reserve University: Cancer Stem Cell Conference (CSC) 2018
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