Cancer Stem Cell News Volume 7.12 | Mar 28 2018

TOP STORY

PSPC1 Mediates TGF-β1 Autocrine Signaling and Smad2/3 Target Switching to Promote EMT, Stemness and Metastasis

Paraspeckle component 1 (PSPC1) promoted tumorigenesis, epithelial-to-mesenchymal transition (EMT), stemness and metastasis in multiple cell types and in spontaneous mouse cancer models. PSPC1 is the master activator for transcription factors of EMT and stemness and accompanies c-Myc activation to facilitate tumor growth. [Nat Cell Biol] Abstract

(Ranked by impact factor of the journal)

JAM3 Maintains Leukemia-Initiating Cell Self-Renewal through LRP5/AKT/β-Catenin/CCND1 Signaling

Scientists revealed that junctional adhesion molecule 3 (JAM3) is highly enriched in both mouse and human leukemia-initiating cells. Leukemogenesis was almost completely abrogated upon Jam3 deletion during serial transplantations in an MLL-AF9-induced murine acute myeloid leukemia model. [J Clin Invest] Full Article

Bivalent Chromatin Domains in Glioblastoma Reveal a Subtype-Specific Signature of Glioma Stem Cells

Researchers profiled six histone modifications and CTCF binding as well as gene expression in primary gliomas, and identified chromatin states that define distinct regulatory elements across the tumor genome. [Cancer Res] Abstract

Targeting Brain-Adaptive Cancer Stem Cells Prohibits Brain Metastatic Colonization of Triple-Negative Breast Cancer

Scientists established novel animal models to investigate early tumor adaptation in brain metastases by introducing both patient-derived and cell line-derived CSC-enriched brain metastasis tumorsphere cells into mice. [Cancer Res] Abstract | Press Release

DC-CIK Cells Derived from Ovarian Cancer Patient Menstrual Blood Activate the TNFR1-ASK1-AIP1 Pathway to Kill Autologous Ovarian Cancer Stem Cells

Researchers collected ovarian cancer patient menstrual blood samples to acquire mononuclear cells and isolated dendritic cell (DC)-cytokine-induced killer (CIK) cells in vitro. In addition, autologous CD44⁺/CD133⁺ ovarian cancer stem cells were isolated and used as target cells. [J Cell Mol Med] Full Article

Comparison of EpCAM^highCD44⁺ Cancer Stem Cells with EpCAM^highCD44⁻ Tumor Cells in Colon Cancer by Single-Cell Sequencing

Investigators determined whether single CSCs and differentiated tumor cells could be distinguished in terms of somatic copy number alterations. [Cancer Biol Ther] Abstract

lncRNA XIST/miR-200c Regulates the Stemness Properties and Tumorigenicity of Human Bladder Cancer Stem Cell-Like Cells

Researchers examined the relationship between long non-coding RNA (lncRNA) X inactive specific transcript (XIST) and miR-200c and assessed their functions in the regulation of the stemness properties and tumorigenicity of human bladder cancer stem cell-like cells. [Cancer Cell Int] Full Article

Let-7c Restores Radio- and Chemo-Sensitivity and Impairs Stemness in Oral Cancer Cells through Inhibiting IL-8

Phenotypical behaviors and the radio/chemoresistance were examined subsequent to overexpression of let-7c. In addition, the expression of let-7c in cancer stem cells was evaluated and the effect of let-7c on stemness characteristics were assessed. [J Oral Pathol Med] Abstract

Role of p38 MAPK in Disease Relapse and Therapeutic Resistance by Maintenance of Cancer Stem Cells (CSCs) in Head and Neck Squamous Cell Carcinoma

The authors investigated the role of p38 MAPK in maintenance of CSC phenotype, therapy resistance and DNA damage repair and response in head and neck squamous cell carcinoma. [J Oral Pathol Med] Abstract

Investigations into the Cancer Stem Cell Niche Using In Vitro 3D Tumor Models and Microfluidics

The authors present a fundamental understanding of CSCs, as well as the CSC niche, and elucidate note-worthy examples of investigations being carried out with regard to each of the major tumor microenvironment components, along with our insights into the potential for further research. [Biotechnol Adv] Abstract

Visit our reviews page to see a complete list of reviews in the cancer stem cell research field.

i2020 to Accelerate Stelvio Therapeutics First-in-Class Epigenetic Platform for Glioblastoma

i2020 Accelerator announced that Stelvio Therapeutics has joined its early drug discovery ecosystem. The i2020 Accelerator deploys a world-wide network of well-established R&D resources, financial and BD&L capabilities to help Stelvio Therapeutics advance its proprietary epigenetic platform for glioblastoma therapies. [Stelvio Therapeutics (PR Newswire Association LLC.)] Press Release

Merus and the Vall d’Hebron Institute of Oncology Announce Research Collaboration to Develop Innovative Bispecific Antibodies for Therapeutic Applications in the Treatment of Cancer

Merus N.V. and the Vall d’Hebron Institute of Oncology announced a strategic research collaboration to develop novel agents for therapeutic applications. [Merus N.V.] Press Release

India Taps Biologist as New Science Adviser

India has a new science adviser. Prime Minister Narendra Modi’s government tapped Krishnaswamy VijayRaghavan, a molecular biologist and head of India’s Department of Biotechnology, to fill the post. [ScienceInsider] Editorial

Cambridge Analytica Controversy Must Spur Researchers to Update Data Ethics

Revelations keep emerging in the Cambridge Analytica personal-data scandal, which has captured global public attention. But when the dust settles, researchers harvesting data online will face greater scrutiny. And so they should. [Nature News] Editorial

Duke’s Mishandling of Misconduct Prompts New U.S. Government Grant Oversight

The U.S. National Institutes of Health imposed unusual new requirements on researchers based at Duke University in Durham, North Carolina, who receive federal funds. The changes are a response to concerns over how the institution handled recent cases involving research misconduct and grant management. [ScienceInsider] Editorial

Massive Cyberhack by Iran Allegedly Stole Research from 320 Universities, Governments, and Companies

Nine Iranians working on behalf of the Islamic Revolutionary Guard Corps hacked the computers of 7998 professors at 320 universities around the world over the past five years, an indictment filed by a federal grand jury alleges. [ScienceInsider] Editorial

NEW Cold Spring Harbor (CSH): Mechanisms & Models of Cancer
August 14-18, 2018
Cold Spring Harbor, New York, United States

Visit our events page to see a complete list of events in the community.

NEW Postdoctoral Position – Cancer, Immunotherapy, and Fibrosis (University of Alabama at Birmingham)

NEW Research Scientist – Gynecologic Cancers (The UCLA G.O. Discovery Laboratory)

NEW Postdoctoral Positions – Cancer Phylogenetics (Massachusetts General Hospital & Harvard Medical School)

Postdoctoral Fellow – Stem Cells and Breast Cancer (Albert Einstein College of Medicine)

Postdoctoral Position – Cancer Research (German Cancer Research Center)

Postdoctoral Fellow – Hematopoietic Stem Cells, Leukemia and Cancer Biology (Washington University School of Medicine, St. Louis)

Postdoctoral Fellowship – Cell and Molecular Biology (Canadian Nuclear Laboratories)

Postdoctoral Positions – Cancer Research (Memorial Sloan Kettering Cancer Center)

Assistant/Associate Investigator/Professor – Gastrointestinal Cancers (Baylor Scott & White Research Institute)

Senior Bioinformatician – Cancer Research (Children´s Cancer Research Institute)

Postdoctoral Fellow – Cancer Biology (Johns Hopkins University)

Faculty Positions – Cancer and Stem Cell Biology (Sun Yat-Sen University)

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