|Cancer Stem Cell News 7.12 March 28, 2018|
Paraspeckle component 1 (PSPC1) promoted tumorigenesis, epithelial-to-mesenchymal transition (EMT), stemness and metastasis in multiple cell types and in spontaneous mouse cancer models. PSPC1 is the master activator for transcription factors of EMT and stemness and accompanies c-Myc activation to facilitate tumor growth. [Nat Cell Biol]
Scientists revealed that junctional adhesion molecule 3 (JAM3) is highly enriched in both mouse and human leukemia-initiating cells. Leukemogenesis was almost completely abrogated upon Jam3 deletion during serial transplantations in an MLL-AF9-induced murine acute myeloid leukemia model. [J Clin Invest]
Researchers profiled six histone modifications and CTCF binding as well as gene expression in primary gliomas, and identified chromatin states that define distinct regulatory elements across the tumor genome. [Cancer Res]
Scientists established novel animal models to investigate early tumor adaptation in brain metastases by introducing both patient-derived and cell line-derived CSC-enriched brain metastasis tumorsphere cells into mice. [Cancer Res]
Researchers collected ovarian cancer patient menstrual blood samples to acquire mononuclear cells and isolated dendritic cell (DC)-cytokine-induced killer (CIK) cells in vitro. In addition, autologous CD44+/CD133+ ovarian cancer stem cells were isolated and used as target cells. [J Cell Mol Med]
Investigators determined whether single CSCs and differentiated tumor cells could be distinguished in terms of somatic copy number alterations. [Cancer Biol Ther]
Researchers examined the relationship between long non-coding RNA (lncRNA) X inactive specific transcript (XIST) and miR-200c and assessed their functions in the regulation of the stemness properties and tumorigenicity of human bladder cancer stem cell-like cells. [Cancer Cell Int]
Phenotypical behaviors and the radio/chemoresistance were examined subsequent to overexpression of let-7c. In addition, the expression of let-7c in cancer stem cells was evaluated and the effect of let-7c on stemness characteristics were assessed. [J Oral Pathol Med]
The authors investigated the role of p38 MAPK in maintenance of CSC phenotype, therapy resistance and DNA damage repair and response in head and neck squamous cell carcinoma. [J Oral Pathol Med]
The authors present a fundamental understanding of CSCs, as well as the CSC niche, and elucidate note-worthy examples of investigations being carried out with regard to each of the major tumor microenvironment components, along with our insights into the potential for further research. [Biotechnol Adv]
Visit our reviews page to see a complete list of reviews in the cancer stem cell research field.
i2020 Accelerator announced that Stelvio Therapeutics has joined its early drug discovery ecosystem. The i2020 Accelerator deploys a world-wide network of well-established R&D resources, financial and BD&L capabilities to help Stelvio Therapeutics advance its proprietary epigenetic platform for glioblastoma therapies. [Stelvio Therapeutics (PR Newswire Association LLC.)]
Merus N.V. and the Vall d’Hebron Institute of Oncology announced a strategic research collaboration to develop novel agents for therapeutic applications. [Merus N.V.]
India has a new science adviser. Prime Minister Narendra Modi’s government tapped Krishnaswamy VijayRaghavan, a molecular biologist and head of India’s Department of Biotechnology, to fill the post. [ScienceInsider]
Revelations keep emerging in the Cambridge Analytica personal-data scandal, which has captured global public attention. But when the dust settles, researchers harvesting data online will face greater scrutiny. And so they should. [Nature News]
The U.S. National Institutes of Health imposed unusual new requirements on researchers based at Duke University in Durham, North Carolina, who receive federal funds. The changes are a response to concerns over how the institution handled recent cases involving research misconduct and grant management. [ScienceInsider]
Nine Iranians working on behalf of the Islamic Revolutionary Guard Corps hacked the computers of 7998 professors at 320 universities around the world over the past five years, an indictment filed by a federal grand jury alleges. [ScienceInsider]
NEW Cold Spring Harbor (CSH): Mechanisms & Models of Cancer
Visit our events page to see a complete list of events in the community.
Have we missed an important article or publication in Cancer Stem Cell News? Click here to submit!
Comments or suggestions? Submit your feedback here.