Cancer Stem Cell News Volume 7.30 | Aug 1 2018

TOP STORY

CCL20 Triggered by Chemotherapy Hinders the Therapeutic Efficacy of Breast Cancer

CCL20 promoted the self-renewal and maintenance of breast CSCs (BCSCs) or breast cancer stem-like cells through protein kinase Cζ or p38 mitogen-activated protein kinase-mediated activation of p65 nuclear factor kappa B (NF-κB) pathway, significantly increasing the frequency and taxane resistance of BCSCs. [PLoS Biol] Full Article

(Ranked by impact factor of the journal)

Adaptive Fibrogenic Reprogramming of Osteosarcoma Stem Cells Promotes Metastatic Growth

Adaptive myofibroblastic reprogramming of osteosarcoma stem cells resulted in a critical advantage when establishing lung macro-metastases and spheroid growth but did not affect the growth of primary lesions or monolayer cultures. [Cell Rep] Full Article | Graphical Abstract

Differential Regulation of the Sphere Formation and Maintenance of Cancer-Initiating Cells of Malignant Mesothelioma via CD44 and ALK4 Signaling Pathways

Cancer-initiating cells, which had high aldehyde dehydrogenase levels and stem cell-associated genes, were expanded in malignant mesothelioma cells cultured under sphere-forming conditions. The knockdown of CD44 or ALK4 strongly suppressed tumor growth in immunodeficient mice. [Oncogene] Full Article

Highly Charged, Cytotoxic, Cyclometalated Iridium(III) Complexes as Cancer Stem Cell Mitochondriotropics

The CSC toxicity and mechanism of action of a series of iridium(III) complexes bearing polypridyl and charged 1-methyl-2-(2-pyridyl)pyridinium ligands, 1-4 is reported. The complex induced CSC apoptosis by mitochondrial membrane depolarization, inhibition of mitochondrial metabolism, and intracellular reactive oxygen species generation. [Chemistry] Abstract

Co-Inhibition of mTORC1, HDAC and ESR1α Retards the Growth of Triple-Negative Breast Cancer and Suppresses Cancer Stem Cells

Fractionated CSCs expressed higher levels of mTORC1 and HDAC than non-CSCs. As a result, co-inhibition of mTORC1, HDAC, and ESR1 was capable of reducing both bulk and CSC subpopulations as well as the conversion of fractionated non-CSC to CSCs in triple-negative breast cancer cells. [Cell Death Dis] Full Article

miR-205-5p Inhibition by Locked Nucleic Acids Impairs Metastatic Potential of Breast Cancer Cells

Scientists showed that miR-205-5p regulated tumorigenic properties of breast cancer cells, as well as epithelial to mesenchymal transition. Silencing this miRNA in breast cancer resulted in reduced tumor growth and metastatic spreading in mouse models. [Cell Death Dis] Abstract

Thyroid Cancer Stem-Like Cell Exosomes: Regulation of EMT via Transfer of lncRNAs

Exosomes from the CSC model transferred the long-non-coding RNAs MALAT1 and the transcription factors SLUG and SOX2 but additionally transferred linc-ROR and induced epithelial-mesenchymal transition (EMT) in normal thyroid cells. Preliminary siRNA studies directed towards linc-ROR reduced invasion. [Lab Invest] Abstract

Stroma-Derived IL-6, G-CSF and Activin-A Mediated Dedifferentiation of Lung Carcinoma Cells into Cancer Stem Cells

Using an elegant co-culture cellular system, investigators were able to prove that nutrients and oxygen deprivation activated non-malignant stromal fibroblasts, which in turn established with tumor cells a paracrine loop mediated by interleukin-6 (IL-6), activin-A and granulocyte colony-stimulating factor (G-CSF), that drove subsequent tumor formation and cellular dedifferentiation. [Sci Rep] Full Article

CLT030, a Leukemic Stem Cell-Targeting CLL1 Antibody-Drug Conjugate for Treatment of Acute Myeloid Leukemia

C-type lectin domain family 12 member A (CLL1)-antibody-drug conjugate inhibited in vitro leukemic stem cell colony formation and demonstrated robust in vivo efficacy in acute myeloid leukemia (AML) cell tumor models and tumor growth inhibition in the AML patient-derived xenograft model. [Blood Adv] Full Article | Graphical Abstract

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Metastatic Niche Functions and Therapeutic Opportunities

The authors highlight the emerging role of the metastatic niche in maintaining cancer stemness and promoting immune evasion, and discuss therapeutic opportunities against the metastatic niche. [Nat Cell Biol] Abstract

Breast Cancer Stem Cells: Features, Key Drivers and Treatment Options

The current view is that breast cancer is a stem cell disease characterized by the existence of cancer cells with stem-like features and tumor-initiating potential. Common therapies by chemotherapeutic drugs fail to eradicate these cells and rather increase the pool of cancer stem cells in tumors, an effect that may increase the likelihood of recurrence. [Semin Cancer Biol] Abstract

Emerging Roles of Myc in Stem Cell Biology and Novel Tumor Therapies

The pathophysiological roles and the therapeutic potentials of Myc family are reviewed. The physiological functions and molecular machineries in stem cells, including embryonic stem cells and induced pluripotent stem cells, are clearly described. [J Exp Clin Cancer Res] Full Article

Visit our reviews page to see a complete list of reviews in the cancer stem cell research field.

Cellectar and Orano Med Announce Collaboration to Develop New Phospholipid Drug Conjugate

Cellectar Biosciences and Orano Med announced that the two companies have entered into an agreement to combine certain proprietary technologies from each company to create a novel oncologic therapy. [Cellectar Biosciences, Inc.; Orano Med (Globe Newswire, Inc.)] Press Release

Lilly Announces Extension of Cancer Research Collaboration with Dana-Farber Cancer Institute

Eli Lilly and Company announced a three-year extension of its cancer research collaboration with Dana-Farber Cancer Institute. Since 2015, scientists from Lilly and Dana-Farber have been working together on pre-clinical and clinical studies, molecular analyses of patient samples and the design and conduct of clinical trials to help advance cancer care. [Eli Lilly and Company] Press Release

FDA Grants Breakthrough Therapy Designation to Daiichi Sankyo’s FLT3 Inhibitor Quizartinib for Relapsed/Refractory FLT3-ITD AML

Daiichi Sankyo Company, Limited announced that the FDA has granted Breakthrough Therapy designation to Quizartinib, an investigational FLT3 inhibitor, for the treatment of adult patients with relapsed/refractory FLT3-ITD acute myeloid leukemia (AML). [Daiichi Sankyo Company, Limited] Press Release

Trump’s Pick to Head White House Science Office Gets Good Reviews

The long wait for a White House science adviser is over. President Donald Trump announced that he intends to nominate meteorologist Kelvin Droegemeier, a university administrator and former vice-chair of the governing board of the U.S. National Science Foundation, to be director of the White House Office of Science and Technology Policy. [ScienceInsider] Editorial

Series of Ethical Stumbles Tests NIH’s Reliance on Private Sector for Research Funding

NIH officials told STAT that the agency is completing a plan to ensure better ethical compliance and better delineate the actual process for private-sector collaboration. The officials said the plan will be presented to an advisory committee in December. [STAT News] Editorial

NEW 6^th Annual Metastatic Breast Cancer Conference
November 15-16, 2018
Baltimore, Maryland, United States

Visit our events page to see a complete list of events in the community.

NEW PhD Student – Translational Bio-Medicine (German Cancer Research Center)

NEW Postdoctoral Fellow – Cancer Stem Cells in Murine Models of Kidney Cancer and Head and Neck Cancer (Weill Cornell Medicine)

Group Leader Positions – Precision Medicine (Italian Institute for Genomic Medicine)

Postdoctoral Fellow – Cancer Research (The University of Texas MD Anderson Cancer Center)

Postdoctoral Scholar – Statistical Bioinformatics (The University of Iowa)

Postdoctoral Positions – Gene Regulation and/or Cancer Biology (University of North Carolina at Chapel Hill School of Medicine)

Postdoctoral Researcher – Cancer Stem Cells and Epitranscriptomics (University of California San Diego)

Postdoctoral Fellowship – Structure-Based Studies for a Search of New Drug Leads for Leukemia Treatment (European Molecular Biology Laboratory)

Postdoctoral Fellow – Cancer Biology (Children’s Cancer Therapy Development Institute)

Tenure-Track Faculty Positions – Various (The Ohio State University)

Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.

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