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Pulmonary Cell News| Cancer Stem Cell News 7.34 August 29, 2018 | |
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TOP STORYResearchers showed that blocking CKIα together with CDK7 and/or CDK9 synergistically stabilized p53, deprived leukemia cells of survival and proliferation-maintaining super-enhancer-driven oncogenes, and induced apoptosis. Leukemia progenitors were selectively eliminated by inhibitors, explaining their therapeutic efficacy with preserved hematopoiesis and leukemia cure potential. [Cell] Abstract | Press Release | Graphical Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)Spheroid cultured TUBO cells, derived from a BALB/neuT primary tumor, developed a cancer stem cell like phenotype and expressed mouse Cripto-1 (mCr-1). Vaccination against mCr-1 reduced primary tumor growth in the 4T1 metastatic breast cancer model and reduced lung metastatic burden. [Cancer Immunol Res] Abstract | Full Article Upon treatment with montelukast, colonospheres derived from HT-29 and SW-480 human colon cancer cells exhibited a significant phenotypic change coupled with the downregulation of mRNA and protein expression of cancer stem cell markers ALDH1 and DCLK1. Montelukast reduced the size of HT-29 cell-derived tumors in mice. [Cancer Lett] Abstract In vitro, chloride intracellular channel 1 (CLIC1) inhibition led to a significant arrest of glioblastoma CSCs in the G1 phase of the cell cycle. Impeding CLIC1-mediated chloride current prevented both intracellular ROS accumulation and pH changes. [Mol Cancer Ther] Abstract Reconstitution experiments indicated that secreted frizzled-related protein-1 (SFRP1) secretion was crucial for Rab37-mediated cancer stemness suppression and treatment with SRPP1 recombinant protein reduced xenograft tumor initiation ability. [Cell Death Dis] Full Article The overexpression of PinX1 in CD133+ CSCs significantly decreased hTERT, inhibited proliferation, migration, and invasion, induced apoptosis, and significantly decreased c-Myc mRNA levels, while it increased TRF1, Mad1, and p53 mRNA levels. [Cell Physiol Biochem] Full Article Silencing tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta (YWHAZ) restored the sensitivity of resistant ovarian cancer cells to cisplatin and paclitaxel. In vitro studies showed that down-regulation of YWHAZ inhibited cell cycle progression, migration, and the expression of stem cell markers. [Cell Physiol Biochem] Full Article PLK1 Inhibitor Facilitates the Suppressing Effect of Temozolomide on Human Brain Glioma Stem Cells As the concentration of temozolomide (TMZ) increased, the expression of polo like kinase 1 (PLK1) protein increased in U87 cells, CD133+ U87 stem cells and CD133-U87 cells. TMZ treatment in cells with low PLK1 protein expression efficiently suppressed cell proliferation and sphere formation, while G2/M arrest was strongly induced. TMZ and PLK1 inhibitor synergized to inhibit glioma growth in vivo. [J Cell Mol Med] Full Article Scientists demonstrated that niclosamide inhibited cisplatin-induced oral squamous cell carcinoma (OSCC) stem cell enrichment and enhanced sensitivity to cisplatin in ALDH+ tumorspheres. [Sci Rep] Full Article ΔNp63 Regulates the Expression of Hyaluronic Acid-Related Genes in Breast Cancer Cells Investigators found that ΔNp63 regulated the expression of hyaluronic acid (HA)-related genes, such as the HA synthase HAS3, the hyaluronidase HYAL-1 and CD44, the major HA cell membrane receptor. By controlling this pathway, ∆Np63 contributed to maintain the self-renewal of breast cancer stem cells. [Oncogenesis] Full Article Subscribe to one of our other 19 science newsletters such as Neural Cell News & Hematopoiesis News. | |
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REVIEWSRole of Tumor Microenvironment in Cancer Stem Cell Chemoresistance and Recurrence The authors highlight the factors that have important roles in chemoresistance and are associated with the bone marrow microenvironment. They discuss the recent progress regarding CSC-targeted therapies to throw light towards developing more effective therapeutic strategies to eradicate cancer in patients. [Int J Biochem Cell Biol] Abstract Visit our reviews page to see a complete list of reviews in the cancer stem cell research field. | |
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INDUSTRY NEWSBaylor Awarded CPRIT Grants for Research, Recruitment Baylor College of Medicine has been awarded more than $31 million by the Cancer Prevention & Research Institute of Texas (CPRIT) to support new research, core facilities and recruitment of new faculty to support the fight against cancer. [Baylor College of Medicine] Press Release Researchers to Test Novel Drug Combination Against Toughest Breast Cancers Tesearchers at the University of California San Diego School of Medicine have launched a Phase Ib clinical trial to assess the safety and tolerability of cirmtuzumab, in combination with standard chemotherapy, to treat metastatic or locally advanced breast cancer that cannot be surgically removed. [University of California San Diego Health] Press Release | |
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POLICY NEWSNIH Investigating Whether U.S. Scientists Are Sharing Ideas with Foreign Governments Fears that foreign governments are tapping U.S.-funded research for valuable information have reached the nation’s largest research funder, the National Institutes of Health (NIH) in Bethesda, Maryland. The NIH sent a letter to more than 10,000 research institutions, urging them to ensure that NIH grantees are properly reporting their foreign ties. [ScienceInsider] Editorial US Senate Passes Spending Bill Granting NIH $39.1 Billion The US Senate passed a spending bill allotting $39.1 billion to the National Institutes of Health (NIH) for the 2019 fiscal year starting on October 1. [The Scientist] Editorial India Targets Universities in Predatory-Journal Crackdown Most academics regard predatory journals as an irritant – if not a threat – to science. But in India, some universities have recommended the inclusion of such publications in the country’s ‘white list’ of approved journals. Now the government is cracking down on this practice, which scientists say came about as a result of perverse government incentives. [Nature News] Editorial
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EVENTSNEW European Society for Medical Oncology (ESMO) 2019 Congress Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Faculty Position – Cancer Biology (Emory University Hospital) Research Scientist – Leukemia (MD Anderson Cancer Center) Research Associate/Senior Research Associate – Acute Myeloid Leukemia (University of Cambridge) PhD Student – Translational Bio-Medicine (German Cancer Research Center) Group Leader Positions – Precision Medicine (Italian Institute for Genomic Medicine) Postdoctoral Fellow – Cancer Research (The University of Texas MD Anderson Cancer Center) Postdoctoral Scholar – Statistical Bioinformatics (The University of Iowa) Tenure-Track Faculty Positions – Various (The Ohio State University) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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