Cancer Stem Cell News Volume 7.50 | Dec 19 2018

TOP STORY

Invasion of White Matter Tracts by Glioma Stem Cells Is Regulated by a NOTCH1-SOX2 Positive-Feedback Loop

The Notch-induced transcription factor Sox9 promoted the transcription of SOX2 and the methylation level of the NOTCH1 promoter was attenuated by the upregulation of SOX2 to reinforce NOTCH1 expression in glioma stem cells. [Nat Neurosci] Abstract

(Ranked by impact factor of the journal)

KDM5B Promotes Drug Resistance by Regulating Melanoma Propagating Cell Subpopulations

Researchers demonstrated that CD34+p75- and CD34-p75- subpopulations carrying the BRAFV600E mutation conferred differential sensitivity to targeted BRAF inhibition. [Mol Cancer Ther] Abstract

Inhibition of Stearoyl-CoA Desaturase 1 Reverts BRAF and MEK Inhibition-Induced Selection of Cancer Stem Cells in BRAF-Mutated Melanoma

BRAF-mutated melanoma 3D cultures enriched for cancer stem cells overexpressed stearoyl-CoA-desaturase and were more resistant than 2D differentiated cultures to BRAF and MEK inhibitors. [J Exp Clin Cancer Res] Full Article

Stemness Marker ALDH1A1 Promotes Tumor Angiogenesis via Retinoic Acid/HIF-1α/VEGF Signaling in MCF-7 Breast Cancer Cells

In MCF-7, scientists observed that aldehyde dehydrogenase 1A1 (ALDH1A1) activity conferred stemness properties and its expression correlated with an activation of angiogenic factors. [J Exp Clin Cancer Res] Full Article

CXCL2/CXCR2 Axis Induces Cancer Stem Cell Characteristics in CPT-11-Resistant LoVo Colon Cancer Cells via Gαi-2 and Gαq/11

CXC ligand 2 (CXCL2) knockdown by short hairpin RNA resulted in reduced expression of cancer stem cell proteins, cyclins, epithelial to mesenchymal transition markers, G proteins, and matrix metalloproteinases. [J Cell Physiol] Abstract

Expression of CD25 Fluctuates in the Leukemia-Initiating Cell Population of CD25-Positive AML

In an in vitro culture system, expression of CD25 was considerably induced in the CD25-negative population of lineage marker-negative CD34⁺ cells from two cases of CD25-positive acute myeloid leukemia (AML). [PLoS One] Full Article

Glutathione Peroxidase 4 Maintains a Stemness Phenotype, Oxidative Homeostasis and Regulates Biological Processes in Panc-1 Cancer Stem-Like Cells

Investigators derived cancer stem-like cell from Panc-1 human pancreatic cancer cells and characterized them using serial replating assays and western blot analysis. [Oncol Rep] Abstract

Analysis of Radio-Sensitivity of Cancer Stem-Like Cells Derived from Canine Cancer Cell Lines

Sphere forming cells, cultured using sphere formation method, were isolated from four types of canine tumor cell lines and evaluated if they had CSC like properties by expression of CSC markers and capacity of tumorigenesis. [Vet Comp Oncol] Abstract

COMMD7 Regulates NF-κB Signaling Pathway in Hepatocellular Carcinoma Stem-Like Cells

Results found that the expression levels of copper metabolism gene MURR1 domain (COMMD) 7 were higher, while COMMD1 were lower in hepatocellular carcinoma tissues and hepatocellular carcinoma stem cells. [Mol Ther Oncolytics] Abstract | Full Article | Graphical Abstract

Targeting Glutaminase 1 Attenuates Stemness Properties in Hepatocellular Carcinoma by Increasing Reactive Oxygen Species and Suppressing Wnt/Beta-Catenin Pathway

Upregulation of glutaminase 1 (GLS1) was positively associated with advanced clinicopathological features and stemness phenotype. Targeting GLS1 reduced the expression of stemness-related genes and suppressed CSC properties in vitro. [EBioMedicine] Full Article

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Lung Cancer Stem Cells: Origin, Features, Maintenance Mechanisms and Therapeutic Targeting

The authors critically address the cancer stem cell concept in lung cancer and its advancement thus far. [Biochem Pharmacol] Abstract | Graphical Abstract

Post-Transcriptional Regulations of Cancer Stem Cell Homeostasis

Investigators highlight the latest advances regarding the functional relevance of different key post-transcriptional regulations and how they are coordinated to control cancer stem cell homeostasis. [Curr Opin Oncol] Abstract

Visit our reviews page to see a complete list of reviews in the cancer stem cell research field.

CHMP positive opinion for approval of Besremi

The Committee for Medicinal Products for Human Use (CHMP) adopted a positive opinion, recommending the granting of a marketing authorization for the medicinal product Besremi, intended for the treatment of polycythaemia vera without symptomatic splenomegaly. [PharmaEssentia Corporation] Press Release

Bristol-Myers Squibb Receives Positive CHMP Opinion Recommending Sprycel (Dasatinib) for Pediatric Patients with Newly Diagnosed Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia

Bristol-Myers Squibb Company announced that the Committee for Medicinal Products for Human Use (CHMP) of the European Medicines Agency has recommended the expanded approval of dasatinib, in combination with chemotherapy, to include the treatment of pediatric patients with newly diagnosed Philadelphia chromosome-positive acute lymphoblastic leukemia. [Bristol-Myers Squibb Company] Press Release

University of California Squares Off against Major Publisher, With Big Stakes for Access to Research

There’s a high-stakes fight in California that could shape the way that academic research gets read and published far beyond the West Coast. The battle is pitting the University of California system against Elsevier, the Netherlands-based publisher of academic journals. At issue is how open-access research gets paid for. [STAT News] Editorial

Canadian Government Ending Networks of Centres of Excellence Program

Canada’s federal government is ending a 30-year-old research funding program, the Networks of Centres of Excellence, leaving researchers uncertain about where future funding will come from, The Globe and Mail reports. The program will be phased out over the course of the next three years, according to a spokesperson for Science Minister Kirsty Duncan. [The Scientist] Editorial

Plan S: The Ambitious Initiative to End the Reign of Paywalls

Efforts to eradicate paywalls have been gaining stream in Europe. Over the last few years, university consortia in several countries have been pushing for open-access agreements in negotiations that have occasionally led to heated stalemates. [The Scientist] Editorial

Australia Cuts Research Funding for Universities

Australian scientists have expressed disappointment over an AU$328.5 million cut to research funding that had been expected over the next four years. In a budget update, the government announced that it will freeze funding increases for the program that supports research, facilities, and training, including of PhDs, at universities. [Nature News] Editorial

NEW 2019 ASCO Annual Meeting
May 31-June 4, 2019
Chicago, Illinois, United States

Visit our events page to see a complete list of events in the community.

NEW Postdoctoral Associate – Cancer Biology (University of Massachusetts)

NEW Postdoctoral Researcher – RNA Biology (Queen Mary University of London)

Assistant Professor – Cancer Biology (Cold Spring Harbor Laboratory)

Tenure-Track/Tenured Faculty – Cancer Biology (University of Chicago)

Research Scientist – Cancer Biology (MD Anderson Cancer Center)

Postdoctoral Position – Cell and Cancer Biology (St. Jude Children’s Research Hospital)

Postdoctoral Scholar – Cancer Stem Cells and Organoids (Cancer Institute of New Jersey)

Clinical Research Fellow – Stem Cell Biology of Medulloblastoma (University of Oxford)

Postdoctoral Research Fellow – Cancer Stem Cells in Brain Tumors (University of Calgary)

Faculty Positions – Cancer & Stem Cell Biology (Duke-NUS Medical School)

Assistant Professor – Cancer Biology (University of Pennsylvania Perelman School of Medicine)

Postdoctoral Associate – Hematopoiesis and Leukemia (The Jackson Laboratory)

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