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Pulmonary Cell News| Cancer Stem Cell News 8.20 May 29, 2019 | |
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TOP STORYDepletion of CSCs occurred in multiple prostate cancer models, indicating a common vulnerability and dependency on mitochondrial dynamics. These effects depended on rewiring of the BRD4-driven transcription and repression of mitochondrial fission factor. [Cell Metab] Abstract | Graphical Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)RASSF1A Controls Tissue Stiffness and Cancer Stem-Like Cells in Lung Adenocarcinoma Researchers showed that adverse prognosis associated with epigenetic silencing of the tumor suppressor RASSF1A was due to increased deposition of extracellular matrix, tumor stiffness and metastatic dissemination in vitro and in vivo. [EMBO J] Full Article | Graphical Abstract The Novel Isatin Analog KS99 Targets Stemness Markers In Acute Myeloid Leukemia KS99 targeted cells coexpressing CD34, CD38, CD123, TIM-3, or CD96 immunophenotypes in acute myeloid leukemia, alone or in combination with the standard therapeutic agent cytarabine. Acute myeloid leukemia with myelodysplastic-related changes was more sensitive than de novo acute myeloid leukemia with or without NPM1 mutation. [Haematologica] Abstract PAK4 Regulates Stemness and Progression in Endocrine Resistant ER-Positive Metastatic Breast Cancer Scientists studied the role of p21-activated kinase 4 (PAK4) as a promising target to overcome endocrine resistance and disease progression in estrogen receptor-positive (ER+) breast cancers. PAK4 predicted for resistance to tamoxifen and poor prognosis in two independent cohorts of ER+ tumors. [Cancer Lett] Full Article Investigators showed a simple and label-free method for the enrichment of CSCs highly expressing CD44 using enzymatically crosslinked hyaluronic acid (HA) hydrogels. HA hydrogels were formed with different crosslink densities to modulate the interaction between the CD44 and HA chains. [Acta Biomater] Abstract | Graphical Abstract While tumor cells and CSCs only expressed the membrane-associated stem cell factor (SCF) isoform, both secreted and membrane-bound isoforms were expressed by tumor-associated macrophages and fibroblasts. Circulating monocytes from epithelial ovarian cancer-bearing patients and healthy donors did not express both SCF isoforms. [Cell Death Dis] Full Article Estrogen receptor alpha (ERα) expression was significantly higher in CD49fHi prostate cancer basal stem-like cells, which showed basal and EMT features with susceptibility to 17β-estradiol treatment. ERα-induced estrogen effects were suggested to drive the NOTCH1 signaling pathway activity via binding to the NOTCH1 promoter. [Cell Commun Signal] Full Article Researchers discovered that miR-139-5p targeted the Wnt/β-catenin/TCF7L2 downstream effector E2-2 in colon CSCs. E2-2 was a pivot molecule in the negative feedback loop of miR-139-5p/Wnt/β-catenin/TCF7L2. [J Cell Physiol] Abstract PES1 Is Regulated by CD44 in Liver Cancer Stem Cells via miR-105-5p Investigators found that pescadillo was upregulated in C3A-induced CSCs (C3A-iCSCs) and promoted cell proliferation. Moreover, the cancer stem cell marker CD44, which was located in the cytomembrane, translocated to the nucleus and was upregulated in C3A-iCSCs. [FEBS Lett] Abstract Scientists demonstrated inhibitory effects of theophylline on melanoma cell proliferation and migration, mainly in melanoma-initiating cells, together with the induction of differentiation parameters. [Life Sci] Abstract Subscribe to one of our other 19 science newsletters such as Neural Cell News & Hematopoiesis News. | |
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REVIEWSOff to a Bad Start: Cancer Initiation by Pluripotency Regulator PRDM14 The pluripotency factor PR domain 14 (PRDM14) has a key role in initiating many types of cancer. PRDM14 and its protein-binding partners, the ETO/CBFA2T family, are ideal candidates for eliminating CSCs from relevant cancers, preventing relapse and improving long-term survival. [Trends Genet] Abstract Chronic Myeloid Leukemia Stem Cells The authors consider biological features of chronic myeloid leukemia (CML) leukemia stem cell (LSCs) defined by assays. They also consider whether CML LSCs are susceptible to targeting by tyrosine kinase inhibitors and other drugs, and whether elimination of CML LSCs is needed to achieve therapy-free remission or cure CML. [Leukemia] Full Article Visit our reviews page to see a complete list of reviews in the cancer stem cell research field. | |
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SCIENCE NEWSPascal Biosciences Inc. announced the company will present at the upcoming BIO International Convention. Kevin Egan, VP Business Development at Pascal, will provide a corporate overview presentation highlighting the company’s therapeutic pipeline. Mr. Egan will describe recent advances in Pascal’s PAS-403 program for glioblastoma. [Press release from Pascal Biosciences, Inc. discussing research presented at the 2019 BIO International Convention, Philadelphia] Press Release | |
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INDUSTRY NEWSRexgenero announced that it has successfully expanded manufacturing of its lead development candidate REX-001 through a partnership with the German Red Cross Blood Donor Service in Frankfurt, Germany, signed earlier this year. [Rexgenero Ltd.] Press Release Celgene Corporation announced the FDA approved REVLIMID® in combination with a rituximab product for the treatment of adult patients with previously treated follicular lymphoma or marginal zone lymphoma following Priority Review designation. [Celgene Corporation] Press Release | |
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POLICY NEWSHere’s Why the Outcomes of This Week’s European Elections Are Good News for Science Although populist and euroskeptic parties grew in last week’s elections for the European Parliament, the tsunami that EU supporters feared didn’t happen. That comes as a relief to many scientists, because several of the populist movements now on the rise in Europe appear to have little interest in science, flirt with antiscientific ideas, or have tried to curtail academic freedom. [ScienceInsider] Editorial White House Sends Mixed Messages on 2020 Research Spending Bills President Donald Trump doesn’t want Congress to boost the budgets of the National Institutes of Health or the National Science Foundation. But he has no objection to giving more research dollars to parts of the Department of Energy and NASA. [ScienceInsider] Editorial
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EVENTSNEW Cell Symposia: Hallmarks of Cancer Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Postdoctoral Scholar – Pediatric Hematology/Oncology (Pennsylvania State University) Faculty Positions – Cancer Research (The University of Texas MD Anderson Cancer Center) Postdoctoral Position – Cancer Biology (Washington University School of Medicine) Postdoctoral Fellow Position – Stem Cells in Colon Cancer (Vanderbilt University Medical Center) Principal Investigator – Cancer Research (Zhejiang University) Research Associates – Cell Competition in Cancer (University of Bristol) Postdoctoral Research Position – Molecular Biology and Cancer Research (Augusta University) Postdoctoral Fellowship – Cancer and Glioma Stem Cell Biology (Cornell University) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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