|Cancer Stem Cell News 8.45 November 20, 2019
Uveal melanoma cells were treated with salinomycin, and its effects on cell proliferation, apoptosis, migration, invasion, cancer stem-like cell populations, and the related signal transduction pathways were determined. [Mol Cancer]
Scientists provided evidence linking the coexistence of hepatitis B virus X protein and transforming growth factor beta 1 (TGF-β1) with miR-199a-3p in the malignanttransformation of hepatic progenitor cells. [Oncogene]
The dual-luciferase reporter gene assay and bioinformatics analysis were used to confirm the interaction between nucleotides. A series of mimics or inhibitors of miR-135a or siRNA against Smo were introduced into esophageal cancer cells. [Mol Ther Nucleic Acids]
Investigators demonstrated that chemokine ligand 8 (CCL8) was highly expressed by tumor-associated macrophages and contributed to pseudopodia formation by glioblastoma cells. The presence of CCL8 in the glioma microenvironment promoted progression of tumor cells. [Lab Invest]
The authors showed for the first time that emergence of CD133+ population coincided with upregulation of growth arrest specific 5 (GAS5), that reprogramed the cell cycle to slow proliferation by inhibiting glucocorticoid receptor mediated cell cycle control. [Oncogenesis]
Scientists stimulated NIH3T3 fibroblasts to exhibit the characteristics of cancer stem-like cells using the whole protein lysates of B16F10 melanoma cells. As a result, they induced colony formation that displayed self-renewal and differentiation capacities through anchorage-independent culture and re-attached culture. [Sci Rep]
Researchers report that the migration potential of non-small cell lung carcinoma was linked to its CSC content. While cisplatin alone failed to inhibit the migration of CSC-enriched non-small cell lung carcinoma spheroids, in a combination with non-steroidal anti inflammatory drug aspirin retards the same. [Sci Rep]
The authors showed that miR-219 was upregulated in liver CSCs. Knockdown of miR-219 attenuated the self-renewal and tumorigenicity of liver CSCs. Conversely, miR-219 overexpressing enhanced the self-renewal and tumorigenicity of liver cancer stem cells. [Cell Cycle]
Triple-negative murine 4T1 breast cancer cells transduced with multi-reporter genes were implanted in immunocompetent Balb/C mice to track, dissect, and identify liver-metastatic 4T1 cells. [Int J Mol Sci]
Researchers observed that FOXO1 not only controlled tumor stemness and metastasis, but also sensitized nasopharyngeal carcinoma cells to cisplatin in vitro and in vivo. Furthermore, they observed FOXO1 interaction with MYH9 and suppression of MYH9 expression by modulating the PI3K/AKT/c-Myc/P53/miR-133a-3p pathway. [Signal Transduct Target Ther]
Scientists discuss mechanisms involved in hypoxia-derived CSC resistance and targeting for effective cancer therapy. Preferential localization within hypoxic niches would help CSCs develop adaptive mechanisms, mediated through the modification of responses to various stressors. [J Cancer Res Clin Oncol]
Visit our reviews page to see a complete list of reviews in the cancer stem cell research field.
Diffusion Pharmaceuticals Inc. announces increased survival in inoperable glioblastoma patients enrolled in the 19-patient, open-label, dose-escalation lead-in portion of its Phase III study with Trans Sodium Crocetinate plus standard of care. [Diffusion Pharmaceuticals Inc.]
Propanc Biopharma, Inc. announced that the POP1 research and drug discovery program has made significant advancements towards producing synthetic versions of the two proenzymes, trypsinogen and chymotrypsinogen. [Propanc Biopharma, Inc.]
Albert Einstein famously insisted that God does not play dice. But the Health Research Council of New Zealand does. The agency is one of a growing number of funders that award grants partly through random selection. [Nature News]
Some researchers have their manuscripts screened for errors before they go to journals. [Nature News]
New guidelines will help Australian universities protect themselves against foreign interference, says the country’s government. The advice follows concerns that foreign groups or governments, such as the government of China, might be seeking to instigate campus activities that are against Australia’s interests. [Nature News]
NEW Advancing Precision Medicine Drug Development: Incorporation of Real-World Data and Other Novel Strategies
Visit our events page to see a complete list of events in the community.
Have we missed an important article or publication in Cancer Stem Cell News? Click here to submit!
Comments or suggestions? Submit your feedback here.