Cancer Stem Cell News Volume 8.45 | Nov 20 2019

TOP STORY

Salinomycin Effectively Eliminates Cancer Stem-Like Cells and Obviates Hepatic Metastasis in Uveal Melanoma

Uveal melanoma cells were treated with salinomycin, and its effects on cell proliferation, apoptosis, migration, invasion, cancer stem-like cell populations, and the related signal transduction pathways were determined. [Mol Cancer] Full Article

(Ranked by impact factor of the journal)

TGF-β1 Accelerates the Hepatitis B Virus X-induced Malignant Transformation of Hepatic Progenitor Cells by Upregulating miR-199a-3p

Scientists provided evidence linking the coexistence of hepatitis B virus X protein and transforming growth factor beta 1 (TGF-β1) with miR-199a-3p in the malignanttransformation of hepatic progenitor cells. [Oncogene] Full Article

MicroRNA-135a Inhibits the Invasion and Migration of Esophageal Cancer Stem Cells through the Hedgehog Signaling Pathway by Targeting Smo

The dual-luciferase reporter gene assay and bioinformatics analysis were used to confirm the interaction between nucleotides. A series of mimics or inhibitors of miR-135a or siRNA against Smo were introduced into esophageal cancer cells. [Mol Ther Nucleic Acids] Abstract | Graphical Abstract | Full Article

CCL8 Secreted by Tumor-Associated Macrophages Promotes Invasion and Stemness of Glioblastoma Cells via ERK1/2 Signaling

Investigators demonstrated that chemokine ligand 8 (CCL8) was highly expressed by tumor-associated macrophages and contributed to pseudopodia formation by glioblastoma cells. The presence of CCL8 in the glioma microenvironment promoted progression of tumor cells. [Lab Invest] Abstract

Long Non-coding RNA GAS5 Acts as Proliferation “Brakes” in CD133⁺ Cells Responsible for Tumor Recurrence

The authors showed for the first time that emergence of CD133⁺ population coincided with upregulation of growth arrest specific 5 (GAS5), that reprogramed the cell cycle to slow proliferation by inhibiting glucocorticoid receptor mediated cell cycle control. [Oncogenesis] Full Article

Extracellular Microenvironmental Change by B16F10 Melanoma-Derived Proteins Induces Cancer Stem-like Cell Properties from NIH3T3 Cells

Scientists stimulated NIH3T3 fibroblasts to exhibit the characteristics of cancer stem-like cells using the whole protein lysates of B16F10 melanoma cells. As a result, they induced colony formation that displayed self-renewal and differentiation capacities through anchorage-independent culture and re-attached culture. [Sci Rep] Full Article

Aspirin Enhances Cisplatin Sensitivity of Resistant Non-Small Cell Lung Carcinoma Stem-Like Cells by Targeting mTOR-Akt Axis to Repress Migration

Researchers report that the migration potential of non-small cell lung carcinoma was linked to its CSC content. While cisplatin alone failed to inhibit the migration of CSC-enriched non-small cell lung carcinoma spheroids, in a combination with non-steroidal anti inflammatory drug aspirin retards the same. [Sci Rep] Full Article

miR-219 Regulates Liver Cancer Stem Cell Expansion via E-cadherin Pathway

The authors showed that miR-219 was upregulated in liver CSCs. Knockdown of miR-219 attenuated the self-renewal and tumorigenicity of liver CSCs. Conversely, miR-219 overexpressing enhanced the self-renewal and tumorigenicity of liver cancer stem cells. [Cell Cycle] Abstract

N-Dihydrogalactochitosan Potentiates the Radiosensitivity of Liver Metastatic Tumor Cells Originated from Murine Breast Tumors

Triple-negative murine 4T1 breast cancer cells transduced with multi-reporter genes were implanted in immunocompetent Balb/C mice to track, dissect, and identify liver-metastatic 4T1 cells. [Int J Mol Sci] Full Article

Chemical Compound Cinobufotalin Potently Induces FOXO1-Stimulated Cisplatin Sensitivity by Antagonizing Its Binding Partner MYH9

Researchers observed that FOXO1 not only controlled tumor stemness and metastasis, but also sensitized nasopharyngeal carcinoma cells to cisplatin in vitro and in vivo. Furthermore, they observed FOXO1 interaction with MYH9 and suppression of MYH9 expression by modulating the PI3K/AKT/c-Myc/P53/miR-133a-3p pathway. [Signal Transduct Target Ther] Full Article

Subscribe to one of our other 19 science newsletters such as Neural Cell News & Hematopoiesis News.

Hypoxia in Solid Tumors: A Key Promoter of Cancer Stem Cell (CSC) Resistance

Scientists discuss mechanisms involved in hypoxia-derived CSC resistance and targeting for effective cancer therapy. Preferential localization within hypoxic niches would help CSCs develop adaptive mechanisms, mediated through the modification of responses to various stressors. [J Cancer Res Clin Oncol] Abstract

Visit our reviews page to see a complete list of reviews in the cancer stem cell research field.

Diffusion Pharmaceuticals Presents Early Findings Showing Increased Survival in Lead-in Portion of Phase III Glioblastoma Study with TSC plus Standard of Care

Diffusion Pharmaceuticals Inc. announces increased survival in inoperable glioblastoma patients enrolled in the 19-patient, open-label, dose-escalation lead-in portion of its Phase III study with Trans Sodium Crocetinate plus standard of care. [Diffusion Pharmaceuticals Inc.] Press Release

Propanc Biopharma Advances POP1 Drug Discovery Program

Propanc Biopharma, Inc. announced that the POP1 research and drug discovery program has made significant advancements towards producing synthetic versions of the two proenzymes, trypsinogen and chymotrypsinogen. [Propanc Biopharma, Inc.] Press Release

Science Funders Gamble on Grant Lotteries

Albert Einstein famously insisted that God does not play dice. But the Health Research Council of New Zealand does. The agency is one of a growing number of funders that award grants partly through random selection. [Nature News] Editorial

The Science Institutions Hiring Integrity Inspectors to Vet Their Papers

Some researchers have their manuscripts screened for errors before they go to journals. [Nature News] Editorial

Foreign Interference Fears Prompt Guidelines for Australian Universities

New guidelines will help Australian universities protect themselves against foreign interference, says the country’s government. The advice follows concerns that foreign groups or governments, such as the government of China, might be seeking to instigate campus activities that are against Australia’s interests. [Nature News] Editorial

NEW Advancing Precision Medicine Drug Development: Incorporation of Real-World Data and Other Novel Strategies
January 9-12, 2020
San Diego, California, United States

Visit our events page to see a complete list of events in the community.

NEW Postdoctoral Studentship – Stem Cell Biology Research (Novo Nordisk Foundation Research Center)

NEW Postdoctoral Position – Molecular Biology or Cancer (University of Liège)

Postdoctoral Fellow – Leukemia (University Hospital of Muenster)

Postdoctoral Studentships – Stem Cell Biology (University of Oxford)

Postdoctoral Position – Immune-targeting of Leukemic Stem Cells (Karolinska Institutet)

Postdoctoral Studentship – HOX Interactors for Leukemia (University of Manchester)

Faculty Positions – Molecular and Cellular Biology (Baylor College of Medicine)

Postdoctoral Scholar – Cancer Biology (University of Kentucky)

Postdoctoral Position – Cellular Immunotherapy for Cancer (Tactiva Therapeutics)

Postdoctoral Position – Cancer Biology (Weill Cornell Medicine)

Assistant, Associate, or Professor – Hematology (Stanford University)

Assistant, Associate or Professor – Oncological Sciences (University of Utah)

Postdoctoral Researcher – Cancer Stem Cells in Glioblastoma (The Institut Curie Research Center)

Postdoctoral Associate – Hematopoietic Stem Cells and Leukemia (The Jackson Laboratory)

Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.

Have we missed an important article or publication in Cancer Stem Cell News? Click here to submit!

Comments or suggestions? Submit your feedback here.