Cancer Stem Cell News Volume 8.49 | Dec 18 2019

TOP STORY

HBO1 Is Required for the Maintenance of Leukemia Stem Cells

Scientists identified the MYST acetyltransferase HBO1 and several known members of the HBO1 protein complex as critical regulators of leukemia stem cell maintenance. [Nature] Abstract | Press Release

(Ranked by impact factor of the journal)

An Intra-Tumoral Niche Maintains and Differentiates Stem-Like CD8 T Cells

Researchers found that CD8 T cells within tumors consisted of distinct populations of terminally differentiated and stem-like cells. On proliferation, stem-like CD8 T cells gave rise to more terminally differentiated, effector-molecule-expressing daughter cells. [Nature] Abstract | Press Release

TRIB3 Supports Breast Cancer Stemness by Suppressing FOXO1 Degradation and Enhancing SOX2 Transcription

Elevated Tribble 3 expression supported breast cancer stem cells by interacting with AKT to interfere with the FOXO1-AKT interaction and suppressed FOXO1 phosphorylation, ubiquitination, and degradation by E3 ligases SKP2 and NEDD4L. [Nat Commun] Full Article

Engineering a Nanostructured Nucleolin-Binding Peptide for Intracellular Drug Delivery in Triple-Negative Breast Cancer Stem Cells

The peptide F3, derived from phage display, promoted the fast and efficient internalization of a genetically fused GFP inside MDA-MB-231 cancer stem cells, in a specific receptor-dependent fashion. [ACS Appl Mater Interfaces] Abstract

ARID1A Prevents Squamous Cell Carcinoma Initiation and Chemoresistance by Antagonizing pRb/E2F1/c-Myc-Mediated Cancer Stemness

The authors showed that Arid1a conditional knockout mice had a high incidence of squamous cell carcinoma occurring in the tongue and esophagus. ARID1A depletion promoted tumor initiation and cancer stemness in human squamous cell carcinoma cells. [Cell Death Differ] Abstract

Krüppel-Like Factor 4 Regulates Stemness and Mesenchymal Properties of Colorectal Cancer Stem Cells through the TGF-β1/Smad/Snail Pathway

Researchers showed that krüppel-like factor 4 (KLF4) overexpression was accompanied with stemness and mesenchymal features in Lgr5⁺CD44⁺EpCAM⁺ colorectal cancer stem cells. [J Cell Mol Med] Full Article

Cancer Stem-Like Cells with Hybrid Epithelial/Mesenchymal Phenotype Leading the Collective Invasion

Scientists performed 3-dimensional assays for investigating the collective invasion from cancer cell spheroids. They demonstrated that cancer stem-like cells could promote both collective and single cell invasion significantly. [Cancer Sci] Abstract

Heparan Sulfate Inhibits Transforming Growth Factor β Signaling and Functions in cis and in trans to Regulate Prostate Stem/Progenitor Cell Activities

Investigators examined the role of heparan sulfate in prostate stem/progenitor cell self-renewal and prostate regeneration. They found that deletion of the glycosyltransferase exostosin 1 abolished heparan sulfate expression in prostate stem/progenitor cells and disrupted their ability to self-renew. [Glycobiology] Abstract

TGIF2 Promotes the Progression of Lung Adenocarcinoma by Bridging EGFR/RAS/ERK Signaling to Cancer Cell Stemness

Researchers report that TGF-β-induced factor homeobox 2 (TGIF2) mediated the EGFR-RAS-ERK signaling pathway to enhance the stemness of lung adenocarcinoma cells and, therefore, promoted the progression and metastasis of lung adenocarcinoma. [Signal Transduct Target Ther] Full Article

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Aldehyde Dehydrogenase-Positive Melanoma Stem Cells in Tumorigenesis, Drug Resistance and Anti-Neoplastic Immunotherapy

The authors review studies that focus on melanoma immunotherapies, rendering aldehyde dehydrogenase a potential marker to evaluate the efficacy of anti-neoplastic therapies or an adjuvant anti-melanoma target. [Mol Biol Rep] Abstract

Visit our reviews page to see a complete list of reviews in the cancer stem cell research field.

The AACR-MPM Oncology Charitable Foundation Announces First Grants to Support Transformative Cancer Research

Two grants for research that could transform cancer therapies have been funded through an innovative partnership between the American Association for Cancer Research (AACR) and MPM Capital through its management of the UBS Oncology Impact Fund. [American Association for Cancer Research] Press Release

Basilea Plans Progression of Oncology Candidate Lisavanbulin to Targeted, Biomarker-Driven Phase II Study

Basilea Pharmaceutica Ltd. announced that it plans to advance the clinical development of its novel tumor checkpoint controller lisavanbulin (BAL101553) by focusing on a targeted, biomarker-driven approach based on the initial results from the two recent Phase I/II clinical studies. [Basilea Pharmaceutica Ltd.] Press Release

Spending Bill Boosts US Science Budgets, Unlocks Gun Research

For the 2020 fiscal year, most US research agencies will receive a funding increase, according to details of a spending bill released by Congress. A total of $2.8 billion of the NIH budget, a boost of $330 million over this year, will be earmarked for Alzheimer’s research, with another $12.5 million for firearm injury and mortality protection research. [The Scientist] Editorial

The Top Retractions of 2019

Another year, another 1,433 (and counting) retractions. The tenth year of Retraction Watch’s existence included-as is often the case-a new record, some impressive numbers, and some bizarre stories. But it also included some exemplary behavior. [The Scientist] Editorial

NIH Considering New Recommendations on Sexual Harassment Policies

Recommendations put forth by the Working Group on Changing the Culture to End Sexual Harassment include requiring NIH-funded institutions to notify the agency within two weeks when a grant recipient is found guilty of sexual misconduct, barring confirmed harassers from serving on NIH advisory councils, and mandating that grant applicants report sexual harassment findings against them. [The Scientist] Editorial

Scientists on the Move

Success in science requires building top performing teams to push the boundaries of what is known-and this means attracting and nurturing scientific talent. In today’s political climate of possible scientific funding cuts and immigration policy uncertainty, headlines forecast a grim effect on scientific research. [Scientific American] Editorial

NEW Beyond a Million Genomes: From Discovery to Precision Health
January 21-25, 2020
Breckenridge, Colorado, United States

Visit our events page to see a complete list of events in the community.

NEW Postdoctoral Scholarship – Brain Tumor Stemness (Lund University)

NEW Research Associate – Cell Communication in Tumor Microenvironments (The University of Cambridge)

PhD Studentship Position – Leukemic Stem Cells and Molecular Biology (Karolinska Institutet)

Postdoctoral Research Scholar – Cancer Biology and Stem Cells (Washington University School of Medicine)

Postdoctoral Research Fellow (German Cancer Research Center)

Postdoctoral Fellow – Molecular Diagnostics and Experimental Therapeutics (City of Hope)

Postdoctoral Position – Molecular Biology or Cancer (University of Liège)

Postdoctoral Studentship – HOX Interactors for Leukemia (University of Manchester)

Postdoctoral Scholar – Cancer Biology (University of Kentucky)

Postdoctoral Position – Cellular Immunotherapy for Cancer (Tactiva Therapeutics)

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