|Cancer Stem Cell News 9.10 March 18, 2020|
Scientists found that most disseminated colorectal cancer cells in circulation were Lgr5– and formed distant metastases in which Lgr5+ CSCs appeared. This plasticity occurred independently of stemness-inducing microenvironmental factors and was indispensable for outgrowth. [Cell Stem Cell]
Serial transplantation of sorted CD4/CD8 and double negative (DN) lymphoma subpopulations identified lymphoma stem cells within the DN3/DN4 T cell population, whereas all other subpopulations failed to establish serial lymphomas. [Leukemia]
Results from gain- and loss-of-unction assays showed that FK506-binding protein 10 (FKBP10) boosted cancer growth and stemness via its peptidyl-prolyl-cis-trans-isomerase activity. FKBP10 interacted with ribosomes, and its downregulation led to reduction of translation elongation at the beginning of open reading frames, particularly upon insertion of proline residues. [Cell Rep]
Researchers generated a new model of liver CSCs by converting mouse induced pluripotent stem cells (miPSCs) with hepatocellular carcinoma cell line Huh7 cells conditioned medium (CM). miPSCs treated with CM were injected into the liver of BALB/c nude mice. [Br J Cancer]
Treatment with KYA1797K, a small molecule that destabilized both β-catenin and RAS via Axin binding, effectively suppressed the stemness of CSCs as shown in colorectal cancer spheroids and small intestinal tumors of ApcMin/+/K-RasG12DLA2 mice. [Cell Commun Signal]
CSCs with miR-495 overexpression or HOXC6 silencing exhibited reversed epithelial-mesenchymal transition process; reduced abilities of proliferation, migration, and invasion; and promoted cell apoptosis in vitro. [Stem Cell Res Ther]
Investigators found that HMGA2 increased breast cancer cell migration and invasion and promoted the acquisition of cancer stem cell features, both in vitro, in colony formation and spheroid assays, and in breast cancer tissues. [Expert Opin Ther Targets]
High levels of histone deacetylase 11 (HDAC11) in human lung tumor tissues correlated with poor patient outcome and depletion or inhibition of HDAC11 not only significantly reduced self-renewal of CSCs from non-small cell lung cancer but also decreased Sox2 expression that was essential for maintenance of CSCs. [Sci Rep]
The generation of SKOV3GL-G4, a metastatic phenotype of SKOV3 green fluorescent protein and luciferase ovarian cancer cells, in xenograft murine ascites showed a correlation between metastatic potential and stem cell characteristics, as indicated by the expression of c-Kit, Notch3, Oct4, Nanog and SOX2. [J Biomed Sci]
The authors review previous studies on the markers of CSCs in oral cancers including oral squamous cell carcinoma, salivary gland cancers, and highlight the most common CSC markers which have potential to be exploited as indicators for the preneoplastic lesion malignancy, oral cancer progression, and/or treatment prognosis. [Life Sci]
Visit our reviews page to see a complete list of reviews in the cancer stem cell research field.
Roche announced that the European Commission has approved Venclyxto® in combination with Gazyvaro® for the treatment of adult patients with previously untreated chronic lymphocytic leukemia. [F. Hoffmann-La Roche Ltd]
Baylor College of Medicine and the University of Houston (UH) are teaming up for new research collaborations. The two Texas Medical Center member institutions have awarded grant funding for nine research projects, each with investigators from both schools, as part of a pilot program resulting from a 2019 Memorandum of Understanding between Baylor College of Medicine and UH to foster new partnerships and research collaborations. [Baylor College of Medicine (University of Houston)]
Academic journals have already taken steps to accelerate the flow of peer-reviewed information by expediting editorial and peer review for coronavirus-related manuscripts and granting them open-access status upon publication. [The Scientist]
Seven counties in the San Francisco Bay Area went into near-lockdown – ushering in a new reality for biopharma companies and biomedical labs. The “shelter in place” order offers significant leeway for medical research. [STAT News]
NEW International Society for Stem Cell Research (ISSCR): Advances in Stem Cell Research: From Single Cells to Organs
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