Cancer Stem Cell News Volume 9.10 | Mar 18 2020

TOP STORY

Plasticity of Lgr5-Negative Cancer Cells Drives Metastasis in Colorectal Cancer

Scientists found that most disseminated colorectal cancer cells in circulation were Lgr5^– and formed distant metastases in which Lgr5⁺ CSCs appeared. This plasticity occurred independently of stemness-inducing microenvironmental factors and was indispensable for outgrowth. [Cell Stem Cell] Full Article | Graphical Abstract

(Ranked by impact factor of the journal)

Existence of Reprogrammed Lymphoma Stem Cells in a Murine ALCL-Like Model

Serial transplantation of sorted CD4/CD8 and double negative (DN) lymphoma subpopulations identified lymphoma stem cells within the DN3/DN4 T cell population, whereas all other subpopulations failed to establish serial lymphomas. [Leukemia] Full Article

FKBP10 Regulates Protein Translation to Sustain Lung Cancer Growth

Results from gain- and loss-of-unction assays showed that FK506-binding protein 10 (FKBP10) boosted cancer growth and stemness via its peptidyl-prolyl-cis-trans-isomerase activity. FKBP10 interacted with ribosomes, and its downregulation led to reduction of translation elongation at the beginning of open reading frames, particularly upon insertion of proline residues. [Cell Rep] Full Article | Graphical Abstract

A Novel Model of Liver Cancer Stem Cells Developed from Induced Pluripotent Stem Cells

Researchers generated a new model of liver CSCs by converting mouse induced pluripotent stem cells (miPSCs) with hepatocellular carcinoma cell line Huh7 cells conditioned medium (CM). miPSCs treated with CM were injected into the liver of BALB/c nude mice. [Br J Cancer] Full Article

Small Molecule-Induced Simultaneous Destabilization of β-Catenin and RAS Is an Effective Molecular Strategy to Suppress Stemness of Colorectal Cancer Cells

Treatment with KYA1797K, a small molecule that destabilized both β-catenin and RAS via Axin binding, effectively suppressed the stemness of CSCs as shown in colorectal cancer spheroids and small intestinal tumors of Apc^Min/+/K-Ras^G12DLA2 mice. [Cell Commun Signal] Full Article

MicroRNA-495 Confers Inhibitory Effects on Cancer Stem Cells in Oral Squamous Cell Carcinoma Through the HOXC6-Mediated TGF-β Signaling Pathway

CSCs with miR-495 overexpression or HOXC6 silencing exhibited reversed epithelial-mesenchymal transition process; reduced abilities of proliferation, migration, and invasion; and promoted cell apoptosis in vitro. [Stem Cell Res Ther] Full Article

Overexpression of HMGA2 in Breast Cancer Promotes Cell Proliferation, Migration, Invasion and Stemness

Investigators found that HMGA2 increased breast cancer cell migration and invasion and promoted the acquisition of cancer stem cell features, both in vitro, in colony formation and spheroid assays, and in breast cancer tissues. [Expert Opin Ther Targets] Abstract

Novel HDAC11 Inhibitors Suppress Lung Adenocarcinoma Stem Cell Self-Renewal and Overcome Drug Resistance by Suppressing Sox2

High levels of histone deacetylase 11 (HDAC11) in human lung tumor tissues correlated with poor patient outcome and depletion or inhibition of HDAC11 not only significantly reduced self-renewal of CSCs from non-small cell lung cancer but also decreased Sox2 expression that was essential for maintenance of CSCs. [Sci Rep] Full Article

A Novel c-Kit/Phospho-Prohibitin Axis Enhances Ovarian Cancer Stemness and Chemoresistance via Notch3-PBX1 and β-Catenin-ABCG2 Signaling

The generation of SKOV3GL-G4, a metastatic phenotype of SKOV3 green fluorescent protein and luciferase ovarian cancer cells, in xenograft murine ascites showed a correlation between metastatic potential and stem cell characteristics, as indicated by the expression of c-Kit, Notch3, Oct4, Nanog and SOX2. [J Biomed Sci] Full Article

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The Current Markers of Cancer Stem Cell in Oral Cancers

The authors review previous studies on the markers of CSCs in oral cancers including oral squamous cell carcinoma, salivary gland cancers, and highlight the most common CSC markers which have potential to be exploited as indicators for the preneoplastic lesion malignancy, oral cancer progression, and/or treatment prognosis. [Life Sci] Abstract | Graphical Abstract

Visit our reviews page to see a complete list of reviews in the cancer stem cell research field.

European Commission Approves Venclyxto plus Gazyvaro for Adults with Previously Untreated Chronic Lymphocytic Leukemia

Roche announced that the European Commission has approved Venclyxto^® in combination with Gazyvaro^® for the treatment of adult patients with previously untreated chronic lymphocytic leukemia. [F. Hoffmann-La Roche Ltd] Press Release

Baylor College of Medicine and the University of Houston Announce Collaborative Grant Awardees

Baylor College of Medicine and the University of Houston (UH) are teaming up for new research collaborations. The two Texas Medical Center member institutions have awarded grant funding for nine research projects, each with investigators from both schools, as part of a pilot program resulting from a 2019 Memorandum of Understanding between Baylor College of Medicine and UH to foster new partnerships and research collaborations. [Baylor College of Medicine (University of Houston)] Press Release

Journals, Peer Reviewers Cope with Surge in COVID-19 Publications

Academic journals have already taken steps to accelerate the flow of peer-reviewed information by expediting editorial and peer review for coronavirus-related manuscripts and granting them open-access status upon publication. [The Scientist] Editorial

Near-Lockdown in the Bay Area ‘Ratchets Up’ Challenges for Local Biotechs and Labs

Seven counties in the San Francisco Bay Area went into near-lockdown – ushering in a new reality for biopharma companies and biomedical labs. The “shelter in place” order offers significant leeway for medical research. [STAT News] Editorial

NEW International Society for Stem Cell Research (ISSCR): Advances in Stem Cell Research: From Single Cells to Organs
October 12-14, 2020
Paris, France

Visit our events page to see a complete list of events in the community.

NEW Postdoctoral Position – Glioma Epigenomic Research (NIH National Cancer Institute)

NEW Postdoctoral Fellow – RAS Proteins and Cancer Cell Stemness (University of Luxembourg)

NEW Postdoctoral Position – Leukemia and Cancer Stemness (Moores Cancer Center, UC San Diego)

Research Fellow – Leukemia Stem Cell Research (Dana Farber Cancer Institute)

Postdoctoral Fellow – Breast Cancer Stem Cells (Albert Einstein College of Medicine)

Research Fellow – Leukemia Stem Cell Biology (University College London)

Postdoctoral Scientist – Stem Cell Biology in Leukemia (University of Manchester)

Postdoctoral Fellow Position – RAS Cancer Cell Biology (University of Luxembourg)

Postdoctoral Researcher – Cancer Cell Invasiveness and Cancer Stem Cells (Cancer Research Center of Lyon)

Postdoctoral Associate – Glioma Stem Cell Biology (Cornell University)

Postdoctoral Research Fellowship – Cancer Biology and Stem Cell Biology (UT Southwestern Medical Center)

Postdoctoral Fellow – Translational Brain Tumor Research (Northwestern University)

Postdoctoral Studentship and PhD Position – Cancer Cell Plasticity (Giessen University)

Postdoctoral Position – Bioinformatics and Leukemia Stem Cells (The Centre for Genomic Regulation)

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