|Cancer Stem Cell News 9.11 March 25, 2020|
Scientists investigated the molecular mechanisms by which DAXX downregulation promoted cancer growth using both in vitro and in vivo models. [Br J Cancer]
The in vitro cytotoxic activity of dendritic cell-activated cytokine-induced killer cell cells against prostate cancer stem-like cells was determined by CCK8 and TUNEL assays. [Stem Cell Res Ther]
Scientists report that membrane metalloendopeptidase cooperated with PTEN in suppression of carcinogenesis by controlling activities of prostate stem/progenitor cells. [Oncogenesis]
Iadademstat blocked CSC-driven mammosphere formation in breast cancer cell lines that were dependent on SOX2 expression to maintain their CSC phenotype. [Aging (Albany NY)]
Investigators isolated CSC-like sphere-forming cells from EBV-associated gastric carcinoma cell line using the cancer sphere method. They validated their CSC-associated properties in the expression of the epithelial-mesenchymal transition-related genes. [Exp Cell Res]
Investigators confirmed that p53-/- murine hepatoblasts acted as tumor-initiating cells that generated combined hepatocellular-cholangiocarcinoma both in situ and within metastases. [Cell Biosci]
Researchers assessed whether inhibition of glioblastoma (GBM) and GBM-derived CSCs by a new tyrosine kinase inhibitor (TKI), K905-0266, was possible. They generated GBM cells expressing luciferase and characterized the inhibitory effects of the TKI with bioluminescent imaging and western blot. [J Drug Target]
Poziotinib, a pan-human epidermal growth factor receptor inhibitor, decreased sphere formation, viability, and proliferation, and induced G1 cell cycle arrest and apoptosis in ovarian CSCs. [Biochem Biophys Res Commun]
Researchers showed that DNA damage-inducible transcript 3 (DDIT3) expression was increased in gastric cancer (GC) tissues. qRT-PCR confirmed that DDIT3 was significantly increased in GC tissues and cancer cell lines compared with healthy tissues and normal cell lines, individually. [J Pharm Pharmacol]
The authors found that CSCs presented marked differences from the non-CSCs, including enrichment in transduction cascades related to stemness, cellular growth, proliferation and apoptosis. [Cells]
The authors review all the relevant literature that addresses the oncogenetic potential of stem cells in epithelial ovarian cancer, their mechanisms, and the associated therapeutic targets. [Arch Gynecol Obstet]
Visit our reviews page to see a complete list of reviews in the cancer stem cell research field.
Genentech, Inc. announced that the Phase III VIALE-A study met its dual primary endpoints of overall survival and composite complete remission rate. Venclexta® in combination with azacitidine, a hypomethylating agent, showed a statistically significant improvement in overall survival in people with previously untreated acute myeloid leukemia who were ineligible for intensive induction chemotherapy, compared to azacitidine alone. [Genentech, Inc.]
Roche announced that the Phase III VIALE-A study met its dual primary endpoints of overall survival and composite complete remission rate. Venclexta®/Venclyxto® in combination with azacitidine, a hypomethylating agent, showed a statistically significant improvement in overall survival in people with previously untreated acute myeloid leukemia who were ineligible for intensive induction chemotherapy, compared to azacitidine alone. [F. Hoffmann-La Roche Ltd]
When five researchers at the University of Washington, Seattle, launched the new Center for an Informed Public back in December 2019, they had no idea what was coming. The center aims to study how misinformation propagates and use the findings to “promote an informed society, and strengthen democratic discourse.” Now, just a few months later, the coronavirus pandemic is generating a tidal wave of information-some of it accurate, some not so much-that has saturated social and traditional media. [ScienceInsider]
As scores of academic meetings get upended due to COVID-19, researchers are turning to virtual replacements. [The Scientist]
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