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| Investigators found a conserved neural tri-lineage cancer hierarchy centered around glial progenitor-like cells. They also found that this progenitor population contained the majority of the cancer’s cycling cells, and, using RNA velocity, was often the originator of the other cell types.
[Nature Communications] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers describe a distinct binary classification of isocitrate dehydrogenase 1/2 (IDH) wild-type glioblastoma (GBM) tumors derived from a quantitative proteomic analysis of 39 IDH wild-type GBMs as well as IDH mutant and low-grade glioma controls.
[Nature Communications] |
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| Investigators studied the role of microenvironmental junctional adhesion molecule-A (JAM-A) in mediating glioblastoma growth.
[Neuro-Oncology] |
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| Researchers investigated the protein sumoylation status, the major sumoylated substrate and the key regulatory enzyme in glioma stem cells to explore the therapeutic potential of disrupting protein sumoylation for glioblastoma treatment.
[Neuro-Oncology] |
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| The functional analysis of CD133+ and CD133− cells in vitro and in vivo revealed that melanoma progression and treatment resistance are the consequences of CD133 signal to PI3K pathway.
[Oncogene] |
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| Researchers showed that CDK5 regulatory subunit-associated protein 3 was weakly expressed in gastric cancer stem-like cells (CSCs) and was negatively correlated with the gastric CSC marker CD44.
[British Journal of Cancer] |
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| In a self-established mouse model consisting normal human breast tissues and normal human bone tissues, triple-negative breast cancer cell line SUM-1315 could spontaneously form species-specific bone metastasis.
[Cell Death & Disease] |
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| miR-146b-5p was downregulated in glioma stem-like cell/mesenchymal stem cell fusion cells, and its overexpression suppressed proliferation, migration and invasion by the fusion cells.
[Aging] |
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| Researchers found that microRNA‐500a‐3p was highly expressed in cisplatin resistant gastric cancer cells and their secreted exosomes than that in the corresponding parental cells.
[Journal of Cellular and Molecular Medicine] |
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| Scientists determined whether EMT and stemness characteristics induced by TGF-β might be associated with epigenetic regulation in lung cancer.
[Scientific Reports] |
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| Researchers summarize current knowledge on the role of the C-C chemokine ligand 5/C-C chemokine receptor type 5 (CCL5/CCR5) axis in cancer.
[Cancers] |
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| Ziopharm Oncology, Inc. announced that the first patient with diffuse intrinsic pontine glioma has been dosed in its Phase I/II study of Ad-RTS-hIL-12 with veledimex for the treatment of pediatric brain tumors.
[ZIOPHARM Oncology Inc.] |
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| The new director of the National Science Foundation (NSF), Sethuraman “Panch” Panchanathan, is familiar with the dark clouds over the agency. His boss, President Donald Trump, keeps proposing big cuts to NSF’s budget. Two recent executive orders on immigration make it harder for foreign scientists—who make up a sizeable share of the U.S. research enterprise—to enter the country.
[Science] |
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| October 12 – October 14
Paris, France |
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| | Lund University – Lund, Sweden |
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| | Massachusetts General Hospital – Charlestown, Massachusetts, United States |
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| | Shanghai Jiao Tong University – Shanghai, China |
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| | City of Hope – Monrovia, California, United States |
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| | University of Freiburg – Freiburg, Germany |
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