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Vol. 9.30 – 12 August, 2020
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Researchers investigated mechanisms by which PAF1 maintains cancer stem cells and contributes to development of pancreatic tumors.
[Gastroenterology]
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PUBLICATIONSRanked by the impact factor of the journal
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Scientists examined the prognostic significance of circulating tumor cell dynamics during treatment in metastatic breast cancer patients receiving first-line chemotherapy.
[JNCI-Journal of the National Cancer institute]
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The authors report that the emergence of refractory phenotypes was highly associated with an aberrant macroautophagic/autophagic state of NANOG+ tumor cells and that the autophagic phenotype arose through transcriptional induction of MAP1LC3B/LC3B by NANOG.
[Autophagy]
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Researchers investigated whether sulforaphane could enhance the chemotherapeutic effects of cisplatin and 5-fluorouracil against head and neck squamous cell carcinomas–cancer stem cells, and its mechanisms of action.
[British Journal of Cancer]
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Scientists examined whether epidermal growth factor receptor (EGFR) signaling affected bone morphogenic protein 4-induced differentiation of glioma stem cells and their response to the alkylating drug temozolomide.
[Experimental and Molecular Medicine]
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Researchers found that selective antagonists of 5-HT5A reduced the frequency of tumorsphere initiating cells residing in breast tumor cell lines and those of patient-derived xenografts that they established.
[BMC Cancer]
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Based on the methods for isolating and identifying cancer stem cells and the functional features of long-term tumor-initiating cells (LT-TICs), the authors aimed to identify a subpopulation of LT-TICs.
[Bioscience Reports]
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Investigators report a copper(II) complex containing a Schiff base ligand and a polypyridyl ligand, 4 capable of inducing immunogenic cell death in breast cancer stem cells.
[Chembiochem]
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Scientists attempted to clarify whether apigenin could improve the antitumor efficiency of cisplatin in lung cancer using cancer stem cells.
[Nutrition and Cancer-An International Journal]
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The authors summarize the most significant advantages and disadvantages of using epithelial cell adhesion molecule as a marker for circulating tumor cell enrichment and its potential biological role in the metastatic cascade.
[Cells]
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BryoLogyx, Inc. announced that it has entered into a Cooperative Research and Development Agreement with the National Cancer Institute, to conduct a Phase I clinical trial with bryostatin-1 in pediatric and young adult patients with relapsing or refractory CD22 expressing acute lymphoblastic leukemia and lymphoma.
[BryoLogyx, Inc.]
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October 26 – October 28
Virtual
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Sanford Burnham Prebys Medical Discovery Institute – La Jolla, California, United States
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Northwestern University – Chicago, Illinois, United States
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The University of Texas Southwestern Medical Center – Dallas, Texas, United States
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Cincinnati Children’s Hospital Medical Center – Cincinnati, Ohio, United States
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West Virginia University – Morgantown, West Virginia, United States
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