 | | Vol. 9.31 – 19 August, 2020 |
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| The authors report the discovery of a mitochondrial oncostatin M that conferred resistance to ionizing radiation via regulation of oxidative phosphorylation, independent of its role in cell proliferation.
[Nature Communications] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| A combination of nanomaterial design and genetic engineering effectively eliminated cancer cells and suppressed stemness of cancer cells in vitro and in vivo.
[Nature Communications] |
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| Investigators aimed to identify a death-associated factor 6 (DAXX)-inducing agent to inhibit tumor initiating cells and prevent proliferation of the tumor.
[npj Breast Cancer] |
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| Leukotriene C4-mediated reduction in the DCLK1 and LGR5 stemness markers in colonospheres was abolished in cells lacking 15-hydroxyprostaglandin dehydrogenase or GLI1.
[Oncogenesis] |
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| Scientists investigated correlations between PD-L1+ cancer stem cells, changes in T-cell phenotype in metastatic and non-metastatic lymph nodes and response to treatment.
[Cancer Immunology Immunotherapy] |
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| Researchers investigated the effect of galiellalactone, a direct STAT3 inhibitor, on CSCs derived from prostate cancer patients, on docetaxel-resistant spheres with stem cell characteristics, on CSCs obtained from the DU145 cell line in vitro and on DU145 tumors in vivo.
[Scientific Reports] |
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| Investigators explored the effect of FL3 in glioblastoma cells under normoxia and hypoxia conditions. They indicated that this synthetic flavagline inhibits cell proliferation and induced senescence in glioblastoma cells cultured under both conditions.
[Scientific Reports] |
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| Researchers compared the effects of tyrosine kinase inhibitors belonging to different generations, imatinib and ponatinib, on progenitor/stem cell expansion potential and markers.
[Targeted Oncology] |
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| The authors showed that heterogeneous glioblastoma cells expressed TNTs upon oxidative stress and temozolomide/ionizing radiation treatment.
[iScience] |
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| Investigators showed that the 2-nitroimidazole doranidazole potentiated radiation-induced DNA damage in hypoxic glioma stem cells (GSCs) and conferred a significant survival benefit in mice harboring GSC-derived tumors in radiotherapy settings.
[Communications Biology] |
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| The authors summarize the current proceedings of how MAPK-AMPK signalings interplay with each other in cancer biology, as well as its implications in clinic cancer treatment with MAPK inhibition and AMPK modulators, and discuss the exploitation of combinatory therapies targeting both MAPK and AMPK as a novel therapeutic intervention.
[Journal of Hematology & Oncology] |
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| Several strategies have been proposed to specifically target CSCs such as the use of CSC‐specific antibodies, small molecules able to target CSCs signaling pathways or drugs able to induce CSCs differentiation rendering them sensitive to classical chemotherapy. These latter compounds are the focus of the present review that aims at reporting recent advances in anticancer differentiation strategy.
[ChemMedChem] |
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| ERC Belgium announced promising interim results in the Phase II clinical trial for ERC1671 under FDA IND 15430 at the University of California, Irvine Medical Center.
[ERC Belgium (Business Wire, Inc.)] |
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| Antengene Corporation announced the authorization of the first-in-human trial of ATG-017 by the Australian Therapeutic Goods Administration. ATG-017 is a potent and selective small molecule extracellular signal–regulated kinases 1 and 2 inhibitor.
[Antengene Corporation] |
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| November 2 – November 3
Virtual |
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| | Sanford Burnham Prebys Medical Discovery Institute – La Jolla, California, United States |
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| | Northwestern University – Chicago, Illinois, United States |
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| | The University of Texas Southwestern Medical Center – Dallas, Texas, United States |
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| | Cincinnati Children’s Hospital Medical Center – Cincinnati, Ohio, United States |
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| | West Virginia University – Morgantown, West Virginia, United States |
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