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Organoid models were employed to show that cancer stem cells (CSCs) and non-CSCs in colorectal cancer were characterized by distinct metabolic phenotypes.
[Cancer Letters]
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Researchers revealed that acidosis reduced vitamin D receptor (VDR) expression by downregulating peroxisome proliferator-activated receptor delta expression. Overexpression of VDR effectively suppressed the stemness and oxaliplatin resistance of cells in acidosis.
[Signal Transduction and Targeted Therapy]
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The three-dimensional organoid model was employed to investigate whether co-culture with paralleled cancer-associated fibroblasts promoted stem-like properties of oral squamous cell carcinoma.
[Journal of Dental Research]
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Investigators elucidated the role of hu-antigen R (HuR) played in pancreatic cancer cell epithelial to mesenchymal transition and developed a novel inhibitor specifically interrupting HuR-RNA binding. [Molecular Cancer therapeutics]
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Scientists showed that the VAV2-regulated stem cell-like program harbored a number of cell cycle- and signaling-related kinases that were essential for the viability of undifferentiated keratinocytes and head and neck squamous cell carcinomapatient-derived cells endowed with high levels of VAV2 activity.
[Cancers]
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Researchers knocked down immunoglobulin kappa J region (RBPJ) expression in two glioblastoma (GBM) cell lines and four GBM stem‐like cell lines derived from surgical samples of GBM to investigate the effect on cell proliferation, invasion, stemness, and tumor formation ability.
[Cancer Science]
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Researchers evaluated the prognostic value of breast cancer stem cells (BCSC)-related long coding RNAs (lncRNAs) and eventually obtained a prognostic risk model consisting of 12 BCSC-related lncRNAs. [Journal of Translational Medicine]
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The authors summarize the crosstalk between aryl hydrocarbon receptor and cancer genetics, with particular emphasis on mechanisms relevant to cancer stem cells such as Wnt/β-catenin pathway, Notch pathway, NF-κB pathway, PTEN-PI3K/Akt pathway and drug resistance-mediating pathways. [Seminars in Cancer Biology]
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Investigators highlight the importance of epitranscriptomic and epiproteomic modification in cancer drug resistance and provide new insights on potential therapeutic targets to reverse cancer drug resistance. [Signal Transduction and Targeted Therapy]
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The authors discuss the pathophysiological roles of special AT-rich binding protein-2 (SATB2) and assess whether it could be used as a therapeutic target for cancer. [Journal of Cellular and Molecular Medicine]
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Ascentage Pharma announced that the FDA has granted APG-2575, an Orphan Drug Designation for the treatment of chronic lymphocytic leukemia.
[Ascentage Pharma (PRNewswire, LLC)]
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The Leukemia & Lymphoma Society and PRA Health Sciences announced a partnership to launch a first-of-its-kind global master clinical trial to develop new treatments for children with relapsed acute leukemia.
[The Leukemia & Lymphoma Society (PRNewswire,LLC)]
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The FDA awarded Rare Pediatric Disease Designation for diffuse intrinsic pontine glioma and Orphan Drug Designation for treatment of malignant glioma to OKN-007.
[Oklahoma Medical Research Foundation]
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Icahn School of Medicine at Mount Sinai – New York City, New York, United States
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St. Anna Children’s Cancer Research Institute – Vienna, Austria
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Sanford Burnham Prebys Medical Discovery Institute – La Jolla, California, United States
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Northwestern University – Chicago, Illinois, United States
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The University of Texas Southwestern Medical Center – Dallas, Texas, United States
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