Cancer Stem Cell News Volume 9.35 | Sep 16 2020

2020-09-16 | CSCN 9.35

Cancer Stem Cell News by STEMCELL Technologies
Vol. 9.35 – 16 September, 2020

Oxidative Metabolism Drives Immortalization of Neural Stem Cells during Tumorigenesis

Researchers demonstrated that metabolic reprogramming induced by mitochondrial fusion was rate-limiting for immortalization of tumor-initiating cells and triggered their irreversible dedication to tumorigenesis.

AbstractGraphical Abstract

Free E-Book: Genome Editing Applications for Disease Modeling and Cell Therapy.
PUBLICATIONSRanked by the impact factor of the journal

Glioma-Initiating Cells at Tumor Edge Gain Signals from Tumor Core Cells to Promote Their Malignancy

Scientists established regionally derived models of glioblastoma edge and core that retained their spatial identity in a cell autonomous manner.
[Nature Communications]

Full Article

Cancer Immunotherapy via Targeting Cancer Stem Cells Using Vaccine Nanodiscs

Researchers presented a novel approach to target and reduce the frequency of aldehyde dehydrogenase (ALDH)high CSCs by vaccination against ALDH.
[Nano Letters]

AbstractGraphical Abstract

Engineered Biomimetic Nanoparticle for Dual Targeting of the Cancer Stem-Like Cell Population in Sonic Hedgehog Medulloblastoma

Investigators demonstrated the dual-targeted delivery and enhanced therapeutic effect of eHNP-A1-CD15-LDE225 via scavenger receptor class B type 1 and CD15 on brain sonic hedgehog subtype of medulloblastoma cells in vitro, ex vivo, and in vivo.
[Proceedings of the National Academy of Sciences of the United States of America]

Full Article

The Stress-Like Cancer Cell State Is a Consistent Component of Tumorigenesis

Scientists found that the stress-like subpopulation of cancer cells was present from the early stages of tumorigenesis.
[Cell Systems]

AbstractGraphical Abstract

Hypoxia Triggers the Intravasation of Clustered Circulating Tumor Cells

When dynamically labeling breast cancer cells along cancer progression, investigators observed that the majority of circulating tumor cells (CTCs) clusters undergone hypoxia, while single CTCs were largely normoxic.
[Cell Reports]

Full ArticleGraphical Abstract

Crosstalk between Hedgehog Pathway and the Glucocorticoid Receptor Pathway as a Basis for Combination Therapy in T-Cell Acute Lymphoblastic Leukemia

Researchers presented a therapeutically relevant crosstalk between Hedgehog signaling and the glucocorticoid receptor pathway acting at the level of GLI1 transcription factor.


Upregulation of CPT1A Is Essential for the Tumor-Promoting Effect of Adipocytes in Colon Cancer

The authors demonstrated that carnitine palmitoyltransferase I (CPT1A), a key enzyme controlling fatty acid oxidation, was upregulated in colon cancer cells upon exposure to adipocytes or fatty acids.
[Cell Death & Disease]

Full Article

Linc-RA1 Inhibits Autophagy and Promotes Radioresistance by Preventing H2Bub1/USP44 Combination in Glioma Cells

Scientists identified a mechanism of radioresistance mediated by linc-RA1 (radioresistance-associated long intergenic noncoding RNA 1). Linc-RA1 was upregulated in radioresistant glioma cells and glioma tissue samples, compared with radiosensitive cells and nontumor tissues.
[Cell Death & Disease]

Full Article

Galectin-3 in Prostate Cancer Stem-Like Cells Is Immunosuppressive and Drives Early Metastasis

Investigators showed that prostate cancer stem-like cells also colonizing prostate-draining lymph nodes of transgenic adenocarcinoma of the mouse prostate mice overexpressed galectin 3.
[Frontiers in Immunology]

Full Article

A Mathematical Model of Average Dynamics in a Stem Cell Hierarchy Suggests the Combinatorial Targeting of Cancer Stem Cells and Progenitor Cells as a Potential Strategy against Tumor Growth

Researchers hypothesized that tumor relapse after the selective targeting of CSCs was due to intermediate progenitor cells that maintained the tumor volume. In order to support this hypothesis, they implemented a mathematical model derived using pseudo-reactions representing the events of each cell subpopulation within the tumor.

Full ArticleGraphical Abstract

Long Non-Coding RNA SNHG3, Induced by IL-6/STAT3 Transactivation, Promotes Stem Cell-Like Properties of Gastric Cancer Cells by Regulating the miR-3619-5p/ARL2 Axis

Scientists clarified the potential involvement of long non-coding RNA SNGH3 in the acquisition of cisplatin resistance and stemness in gastric cancer.
[Cellular Oncology]


Bruno Silva-Santos shares his work on understanding the role of gamma delta T cells in cancer immunity. Watch the webinar.

Epigenomic Reprogramming as a Driver of Malignant Glioma

The authors describe key chromatin regulatory pathways disrupted in gliomas, delineating their physiological function and the current understanding of how their dysregulation may contribute to gliomagenesis.
[Cancer Cell]


Co-Targeting of Lysosome and Mitophagy in Cancer Stem Cells with Chloroquine Analogues and Antibiotics

Investigators provide a sketch of the inhibiting roles of current chloroquine analogues and antibiotic combination in CSC autophagy process and discuss the possibility that pre‐clinical and clinical potential therapeutic strategy for anticancer therapy.
[Journal of Cellular and Molecular Medicine]

Full Article

Dual Effects of Non-Coding RNAs (ncRNAs) in Cancer Stem Cell Biology

The authors discuss the multifaceted contribution of microRNAs, long non-coding RNAs, and circular RNAs, as representative ncRNA classes, in sustaining the CSC-like traits, as well as the underlying molecular mechanisms of their action in various CSC types.
[International Journal of Molecular Sciences]

Full Article


First Patient Dosed in Europe within the Expansion Cohort of Phase I/II Clinical Study of SEL24/MEN1703 in Acute Myeloid Leukemia

Ryvu Therapeutics announced that the first patient had been treated in Europe for the cohort expansion part of Phase II DIAMOND-01 clinical trial investigating SEL24/MEN1703, a first-in-class, oral dual PIM/FLT3 inhibitor, as single agent in acute myeloid leukemia.
[Ryvu Therapeutics]

Press Release

FDA Granted Pediatric Disease Designation for OXi-4503

Mateon Therapeutics announced that the FDA designated OXi4503 for treatment of acute myeloid leukemia due to genetic mutations that disproportionately affected pediatric patients as a drug for a “rare pediatric disease,” as defined in section 529(a)(3) of the Federal Food, Drug, and Cosmetic Act.
[Mateon Therapeutics]

Press Release


Cell Biology 2020

September 23

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Assistant/Associate Professor – Center for Molecular Medicine

The University of Georgia – Athens, Georgia, United States

Postdoctoral Position – Cancer Stem Cell Biology

Karolinska Institute – Solna, Sweden

Postdoctoral Researcher – Cancer Stem Cell Biology

Karolinska Institute – Solna, Sweden

Postdoctoral Position – Human Pluripotent Stem Cells, Hematopoiesis and Leukemia

Icahn School of Medicine at Mount Sinai – New York City, New York, United States

Postdoctoral Fellow – Immunology, Genetics, Precision Medicine

St. Anna Children’s Cancer Research Institute – Vienna, Austria

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