 | | Vol. 9.35 – 16 September, 2020 |
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| Researchers demonstrated that metabolic reprogramming induced by mitochondrial fusion was rate-limiting for immortalization of tumor-initiating cells and triggered their irreversible dedication to tumorigenesis.
[Cell] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists established regionally derived models of glioblastoma edge and core that retained their spatial identity in a cell autonomous manner.
[Nature Communications] |
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| Researchers presented a novel approach to target and reduce the frequency of aldehyde dehydrogenase (ALDH)high CSCs by vaccination against ALDH.
[Nano Letters] |
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| Investigators demonstrated the dual-targeted delivery and enhanced therapeutic effect of eHNP-A1-CD15-LDE225 via scavenger receptor class B type 1 and CD15 on brain sonic hedgehog subtype of medulloblastoma cells in vitro, ex vivo, and in vivo.
[Proceedings of the National Academy of Sciences of the United States of America] |
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| Scientists found that the stress-like subpopulation of cancer cells was present from the early stages of tumorigenesis.
[Cell Systems] |
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| When dynamically labeling breast cancer cells along cancer progression, investigators observed that the majority of circulating tumor cells (CTCs) clusters undergone hypoxia, while single CTCs were largely normoxic.
[Cell Reports] |
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| Researchers presented a therapeutically relevant crosstalk between Hedgehog signaling and the glucocorticoid receptor pathway acting at the level of GLI1 transcription factor.
[Oncogene] |
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| The authors demonstrated that carnitine palmitoyltransferase I (CPT1A), a key enzyme controlling fatty acid oxidation, was upregulated in colon cancer cells upon exposure to adipocytes or fatty acids.
[Cell Death & Disease] |
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| Scientists identified a mechanism of radioresistance mediated by linc-RA1 (radioresistance-associated long intergenic noncoding RNA 1). Linc-RA1 was upregulated in radioresistant glioma cells and glioma tissue samples, compared with radiosensitive cells and nontumor tissues.
[Cell Death & Disease] |
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| Investigators showed that prostate cancer stem-like cells also colonizing prostate-draining lymph nodes of transgenic adenocarcinoma of the mouse prostate mice overexpressed galectin 3.
[Frontiers in Immunology] |
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| Researchers hypothesized that tumor relapse after the selective targeting of CSCs was due to intermediate progenitor cells that maintained the tumor volume. In order to support this hypothesis, they implemented a mathematical model derived using pseudo-reactions representing the events of each cell subpopulation within the tumor.
[Cancers] |
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| Scientists clarified the potential involvement of long non-coding RNA SNGH3 in the acquisition of cisplatin resistance and stemness in gastric cancer.
[Cellular Oncology] |
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| The authors describe key chromatin regulatory pathways disrupted in gliomas, delineating their physiological function and the current understanding of how their dysregulation may contribute to gliomagenesis.
[Cancer Cell] |
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| Investigators provide a sketch of the inhibiting roles of current chloroquine analogues and antibiotic combination in CSC autophagy process and discuss the possibility that pre‐clinical and clinical potential therapeutic strategy for anticancer therapy.
[Journal of Cellular and Molecular Medicine] |
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| The authors discuss the multifaceted contribution of microRNAs, long non-coding RNAs, and circular RNAs, as representative ncRNA classes, in sustaining the CSC-like traits, as well as the underlying molecular mechanisms of their action in various CSC types.
[International Journal of Molecular Sciences] |
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| Ryvu Therapeutics announced that the first patient had been treated in Europe for the cohort expansion part of Phase II DIAMOND-01 clinical trial investigating SEL24/MEN1703, a first-in-class, oral dual PIM/FLT3 inhibitor, as single agent in acute myeloid leukemia.
[Ryvu Therapeutics] |
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| Mateon Therapeutics announced that the FDA designated OXi4503 for treatment of acute myeloid leukemia due to genetic mutations that disproportionately affected pediatric patients as a drug for a “rare pediatric disease,” as defined in section 529(a)(3) of the Federal Food, Drug, and Cosmetic Act.
[Mateon Therapeutics] |
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| | The University of Georgia – Athens, Georgia, United States |
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| | Karolinska Institute – Solna, Sweden |
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| | Karolinska Institute – Solna, Sweden |
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| | Icahn School of Medicine at Mount Sinai – New York City, New York, United States |
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| | St. Anna Children’s Cancer Research Institute – Vienna, Austria |
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