Cancer Stem Cell News Volume 9.36 | Sep 23 2020

2020-23-09 | CSC 9.36

Cancer Stem Cell News by STEMCELL Technologies
Vol. 9.36 – 23 September, 2020

The Lysophospholipase D Enzyme Gdpd3 Is Required to Maintain Chronic Myelogenous Leukemia Stem Cells

Investigators showed that disruption of the Gdpd3 gene encoding a lysophospholipase D enzyme significantly decreased self-renewal capacity in murine chronic myelogenous leukemia stem cells in vivo.
[Nature Communications]

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SPT6-Driven Error-Free DNA Repair Safeguards Genomic Stability of Glioblastoma Cancer Stem-Like Cells

Researchers presented the results of a high-content siRNA microscopy screen, revealing the transcriptional elongation factor SPT6 to be critical for the genomic stability and self-renewal of glioblastoma cancer-stem like cells.
[Nature Communications]

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LncRNA HotairM1 Depletion Promotes Self-Renewal of Cancer Stem Cells through HOXA1-Nanog Regulation Loop

Based on analysis of transcriptome sequencing, scientists identified a long noncoding RNA (lncRNA) named HotairM1 that was weakly expressed in human colorectal carcinoma and uveal melanoma, and a much lower expression in corresponding CSCs.
[Molecular Therapy-Nucleic Acids]

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Exosomal LncRNA DOCK9-AS2 Derived from Cancer Stem Cell-Like Cells Activated Wnt/β-Catenin Pathway to Aggravate Stemness, Proliferation, Migration, and Invasion in Papillary Thyroid Carcinoma

DOCK9-AS2 knockdown reduced proliferation, migration, invasion, epithelial-to-mesenchymal and stemness in papillary thyroid carcinoma cells.
[Cell Death & Disease]

Full Article

Wnt/β-Catenin Signaling Pathway Induces Autophagy-Mediated Temozolomide-Resistance in Human Glioblastoma

Investigators demonstrated that the loss of DOC-2/DAB2 interacting protein (DAB2IP) was responsible for temozolomide (TMZ)-resistance in glioblastoma multiforme (GBM) through ATG9B. DAB2IP sensitized GBM to TMZ and suppressed TMZ-induced autophagy by negatively regulating ATG9B expression.
[Cell Death & Disease]

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A Myristoyl Amide Derivative of Doxycycline Potently Targets Cancer Stem Cells (CSCs) and Prevents Spontaneous Metastasis, without Retaining Antibiotic Activity

Researchers described the chemical synthesis and biological activity of a new doxycycline derivative, designed specifically to more effectively target CSCs.
[Frontiers in Oncology]

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Attenuating Hypoxia Driven Malignant Behavior in Glioblastoma with a Novel Hypoxia-Inducible Factor 2 Alpha Inhibitor

Scientists investigated a novel hypoxia inducible factor2α inhibitor, PT2385, both in vitro, with low-passage patient-derived cell lines, and in vivo, using orthotopic models of glioblastoma.
[Scientific Reports]

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Quantitative In Vivo Bioluminescence Imaging of Orthotopic Patient-Derived Glioblastoma Xenografts

The authors showed that stable expression of near-infrared fluorescent protein in patient-derived glioblastoma cells enabled rapid, direct non-invasive monitoring of tumor development without compromising tumor stemness or tumorigenicity.
[Scientific Reports]

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Methionine Represses the Autophagy of Gastric Cancer Stem Cells via Promoting the Methylation and Phosphorylation of RAB37

Scientists focused on the role of methionine in the autophagy of gastric cancer stem cells and elaborated its regulatory mechanism.
[Cell Cycle]


Matrix Metalloprotease-7 Mediates Nucleolar Assembly & Intra-Nucleolar Cleaving p53 in Gefitinib Resistant Cancer Stem Cells

Investigators showed that matrix metalloproteinase-7 shedding MUC-1 SEA domain releases MUC-1 C-ter facilitating the nucleolus trafficking of p53 in gefitinib-resistant lung cancer stem cells.

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The Role of Breast Cancer Stem Cell-Related Biomarkers as Prognostic Factors

The cell-surface and subcellular biomarkers related to breast cancer stem cell (BCSC) phenotypes are increasingly being recognised. These biomarkers are useful for the isolation of BCSCs and can serve as potential therapeutic targets and prognostic tools to monitor treatment responses.
[Diagnostics ]

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The Role of Smoothened in Cancer

Smoothened (SMO) expression correlates with tumor size, invasiveness, metastasis and recurrence. In addition, SMO inhibitors can suppress cancer formation, reduce the proliferation of cancer cells, trigger apoptosis and suppress cancer stem cell activity.
[International Journal of Medical Sciences]

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Jazz Pharmaceuticals Launches Initiative to Help Educate People Living with Rare Form of Leukemia

Jazz Pharmaceuticals plc announced the launch of Find the Right Fit, a US patient education program developed in consultation with the Myelodysplastic Syndromes (MDS) Foundation, Inc. and the Cancer Support Community focused on empowering people affected by secondary acute myeloid leukemia and MDS.
[Jazz Pharmaceuticals plc]

Press Release

NIH Funds Research into Differences in Glioblastoma between Males and Females

A team led by researchers from Case Western Reserve University School of Medicine and Cleveland Clinic’s Lerner Research Institute has secured $10.4 million over five years from the National Institutes of Health/National Cancer Institute to explore at the molecular level the differences in glioblastoma between males and females.
[Cleveland Clinic Lerner Research Institute]

Press Release


10 Million Reasons to Defeat Cancer 2020 – Abbott World Summit

October 13 – October 14

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Postdoctoral Fellow – Stem Cells and Cancer

Albert Einstein College of Medicine – New York, New York, United States

Assistant/Associate Professor – Center for Molecular Medicine

The University of Georgia – Athens, Georgia, United States

Postdoctoral Position – Cancer Stem Cell Biology

Karolinska Institute – Solna, Sweden

Postdoctoral Position – Human Pluripotent Stem Cells, Hematopoiesis and Leukemia

Icahn School of Medicine at Mount Sinai – New York City, New York, United States

Postdoctoral Fellow – Immunology, Genetics, Precision Medicine

St. Anna Children’s Cancer Research Institute – Vienna, Austria

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