 | | Vol. 9.36 – 23 September, 2020 |
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| Investigators showed that disruption of the Gdpd3 gene encoding a lysophospholipase D enzyme significantly decreased self-renewal capacity in murine chronic myelogenous leukemia stem cells in vivo.
[Nature Communications] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers presented the results of a high-content siRNA microscopy screen, revealing the transcriptional elongation factor SPT6 to be critical for the genomic stability and self-renewal of glioblastoma cancer-stem like cells.
[Nature Communications] |
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| Based on analysis of transcriptome sequencing, scientists identified a long noncoding RNA (lncRNA) named HotairM1 that was weakly expressed in human colorectal carcinoma and uveal melanoma, and a much lower expression in corresponding CSCs.
[Molecular Therapy-Nucleic Acids] |
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| DOCK9-AS2 knockdown reduced proliferation, migration, invasion, epithelial-to-mesenchymal and stemness in papillary thyroid carcinoma cells.
[Cell Death & Disease] |
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| Investigators demonstrated that the loss of DOC-2/DAB2 interacting protein (DAB2IP) was responsible for temozolomide (TMZ)-resistance in glioblastoma multiforme (GBM) through ATG9B. DAB2IP sensitized GBM to TMZ and suppressed TMZ-induced autophagy by negatively regulating ATG9B expression.
[Cell Death & Disease] |
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| Researchers described the chemical synthesis and biological activity of a new doxycycline derivative, designed specifically to more effectively target CSCs.
[Frontiers in Oncology] |
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| Scientists investigated a novel hypoxia inducible factor2α inhibitor, PT2385, both in vitro, with low-passage patient-derived cell lines, and in vivo, using orthotopic models of glioblastoma.
[Scientific Reports] |
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| The authors showed that stable expression of near-infrared fluorescent protein in patient-derived glioblastoma cells enabled rapid, direct non-invasive monitoring of tumor development without compromising tumor stemness or tumorigenicity.
[Scientific Reports] |
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| Scientists focused on the role of methionine in the autophagy of gastric cancer stem cells and elaborated its regulatory mechanism.
[Cell Cycle] |
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| Investigators showed that matrix metalloproteinase-7 shedding MUC-1 SEA domain releases MUC-1 C-ter facilitating the nucleolus trafficking of p53 in gefitinib-resistant lung cancer stem cells.
[iScience] |
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| The cell-surface and subcellular biomarkers related to breast cancer stem cell (BCSC) phenotypes are increasingly being recognised. These biomarkers are useful for the isolation of BCSCs and can serve as potential therapeutic targets and prognostic tools to monitor treatment responses.
[Diagnostics ] |
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| Smoothened (SMO) expression correlates with tumor size, invasiveness, metastasis and recurrence. In addition, SMO inhibitors can suppress cancer formation, reduce the proliferation of cancer cells, trigger apoptosis and suppress cancer stem cell activity.
[International Journal of Medical Sciences] |
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| Jazz Pharmaceuticals plc announced the launch of Find the Right Fit, a US patient education program developed in consultation with the Myelodysplastic Syndromes (MDS) Foundation, Inc. and the Cancer Support Community focused on empowering people affected by secondary acute myeloid leukemia and MDS.
[Jazz Pharmaceuticals plc] |
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| A team led by researchers from Case Western Reserve University School of Medicine and Cleveland Clinic’s Lerner Research Institute has secured $10.4 million over five years from the National Institutes of Health/National Cancer Institute to explore at the molecular level the differences in glioblastoma between males and females.
[Cleveland Clinic Lerner Research Institute] |
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| October 13 – October 14
Virtual |
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| | Albert Einstein College of Medicine – New York, New York, United States |
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| | The University of Georgia – Athens, Georgia, United States |
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| | Karolinska Institute – Solna, Sweden |
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| | Icahn School of Medicine at Mount Sinai – New York City, New York, United States |
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| | St. Anna Children’s Cancer Research Institute – Vienna, Austria |
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