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| Vol. 9.37 – 30 September, 2020
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Investigators evaluated in vitro the expression and the biological function of DCLK1 in intrahepatic cholangiocarcinom (CCA) and perihilar CCA.
[Hepatology]
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| PUBLICATIONSRanked by the impact factor of the journal
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ATR-defective cells were defective in neuronal migration during development and in metastatic dissemination from circulating tumor cells.
[Nature Communications]
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The arginine methyltransferase PRMT5 can methylate lymphoid-specific helicase (LSH) at R309 residue, meanwhile, LSH could as well be phosphorylated by MAPK1 kinase at S503 residue.
[Signal Transduction and Targeted Therapy]
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Scientists performed BSH-polyR-based boron neutron capture therapy (BNCT) against glioma stem-like cells and revealed that BSH-polyR successfully induced BNCT-dependent cell death specifically in CD44High cells.
[Cells]
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Knockdown of S100A10 in breast cancer cells suppressed and overexpression of S100A10 in breast cancer patient‐derived tumor xenograft cells enhanced their invasion abilities and 3D organoid formation capacities in vitro.
[Cancer Science]
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Scientists studied the importance of paracrine signaling in the glioma microenvironment by focusing on the celecoxib-mediated role of chemokines C–C motif ligand 2, C-X-C ligand 10, and their receptors, CCR2 and CXCR3, in glioma stem cells (GSCs) and a GSC-bearing malignant glioma model.
[Scientific Reports]
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Investigators isolated the compound 6-methoxymellein, which inhibits the proliferation and migration of breast cancer cells, reduces mammosphere growth, decreases the proportion of CD44+/CD24− cells in breast cancer cells and decreases the expression of stemness-associated proteins c-Myc, Sox-2 and Oct4.
[Molecules]
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Researchers collected the gene expression profiles of ovarian (O)CSCs were from five public cohorts and employed R software and Bioconductor packages to establish differently expressed genes between OCSCs and parental cells.
[Journal of Ovarian Research]
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Human induced pluripotent stem cells were converted into CSCs in the presence of conditioned medium from PK8 cells. CSCs were then transplanted in vivo and formed primary tumors.
[Acta Histochemica]
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The authors provide evidence on the functional role of HOX transcript antisense intergenic RNA (HOTAIR) in gliomas and discuss the benefits of its targeting as a novel approach toward glioma treatment.
[Journal of Molecular Medicine]
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Apollomics, Inc. announced APL-106 has received Investigational New Drug approval from the China National Medical Products Administration Center for Drug Evaluation. This approval enables the initiation of a Phase I pharmacokinetic and tolerability study and includes acceptance of a Phase III bridging study of APL-106 in combination with chemotherapy in relapsed/refractory acute myeloid leukemia.
[Apollomics, Inc.]
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Basilea Pharmaceutica Ltd. announced that it has initiated a Phase II expansion study with its tumor checkpoint controller, lisavanbulin, in patients with recurrent glioblastoma multiforme, whose tumor has tested positive for the potential response-predictive biomarker end-binding protein 1.
[Basilea Pharmaceutica Ltd. ]
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Dec 8 – Dec 12, 2020
Virtual
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| The Mayo Clinic – Jacksonville, Florida, United States
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| Albert Einstein College of Medicine – New York, New York, United States
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| The University of Georgia – Athens, Georgia, United States
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| Karolinska Institute – Solna, Sweden
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| Icahn School of Medicine at Mount Sinai – New York City, New York, United States
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Cancer Stem Cell News
Cell Therapy News
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