Cancer Stem Cell News Volume 9.38 | Oct 7, 2020


    2020-10-07 | CSCN 9.38

    Cancer Stem Cell News by STEMCELL Technologies
    Vol. 9.38 – 07 October, 2020

    RNA m6A Reader YTHDF2 Maintains Oncogene Expression and Is a Targetable Dependency in Glioblastoma Stem Cells

    Researchers interrogated N6-methyladenosine (m5A) mRNA modifications in glioma stem cells by methyl RNA-immunoprecipitation followed by sequencing and transcriptome analysis, finding transcripts marked by m6A often upregulated compared to normal neural stem cells.
    [Cancer Discovery]


    Watch the webinar where Dr. Suzan Imren discusses factors affecting the balance between HSC self-renewal and leukemic transformation
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    Modulator Inhibition Overcomes Temozolomide Chemoresistance and Antagonizes Tumor Recurrence of Glioblastoma

    Investigators identified a specific glioblastoma multiforme stem-like cells subset and showed that activity of these cells was positively regulated by stabilization of methyl CpG binding domain 3 protein.
    [Journal of Clinical Investigation]

    Full ArticleGraphical Abstract

    Remodeling of the Extracellular Matrix Drives Loss of Cancer Stem Cells and Tumor Rejection

    Extracellular matrix-rich tumors exhibited a stem cell-like gene expression profile and superior tumor-initiating capacity, whereas such features were absent in responder tumors.
    [Cancer Immunology Research]

    AbstractFull Article

    of Neuropilin-1 Improves the Therapeutic Response in Conventional Drug-Resistant Glioblastoma Multiforme

    Scientists observed that patient-derived glioblastoma cells expressing shRNAs of VEGF or neuropilin-1 attenuated cancer stem cell markers, inhibited the tumor-initiating cell’s neurosphere-forming capacity, and migration.


    GTPase RAB6 Deficiency Promotes Alveolar Progenitor Cell Renewal and Attenuates PM2.5-Induced Lung Injury and Fibrosis

    Investigators demonstrated that knockout of RAB6 inhibited pulmonary fibrosis, oxidative stress, and type 2 alveolar epithelial cells (AEC2) cell death in fine particulate matter (PM2.5)-injured mice. In addition, knockout of RAB6 decreased Dickkopf 1 autocrine and activated proliferation, self-renewal, and wnt/β-catenin signaling of PM2.5-injured AEC2 cells.
    [Cell Death & Disease]

    Full Article

    Long-Term Helicobacter pylori
    Infection Switches Gastric Epithelium Reprogramming Towards Cancer Stem Cell-Related Differentiation Program in Hp-Activated Gastric Fibroblast-TGFβ Dependent Manner

    TGFβ1 rich secretome from Helicobacter pylori-reprogrammed fibroblasts prompted phenotypic plasticity and epithelial–mesenchymal transition (EMT) of gastric epithelium, inducing pro-neoplastic expansion of post-EMT cells in the presence of low TGFβR1 and TGFβR2 activity.

    AbstractFull Article

    Regulates Proliferation, Invasion and STAT3-Mediated Cancer Stem Cell-Dependent Chemoresistance in Ovarian Cancer Cells

    FT282, JHOS2 and OVCAR4 cells were transiently transfected with either single or pooled TIMP-2 siRNAs. The expression of different genes after TIMP-2 knock down or in response to chemotherapy was determined at the mRNA level by quantitative real time PCR and at the protein level by immunofluorescence.
    [BMC Cancer]


    Overcomes Cisplatin Resistance in Lung Cancer by Inhibiting Cancer Cell Stemness

    Scientists used aspirin, a nonselective COX inhibitor, with cisplatin for several hours in cells and days in vivo, and studied the inhibition against human cisplatin‐resistant H460 cells.
    [Thoracic Cancer]

    Full Article

    Tumor-Associated Macrophages Derived from Cancer Stem Cells

    This study displayed histological and immunohistochemical analyses of a malignant tumor model developed from cancer stem cells converted from human iPSCs in a cancer microenvironment prepared from the conditioned medium of a pancreatic cancer cell line.
    [Acta Histochemica]

    Full Article

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    Mitochondrial Respiration for the Treatment of Acute Myeloid Leukemia

    Scientists discuss the relative dependency that acute myeloid leukemia (AML) cells have on mitochondrial function, and the ability to pivot this reliance to target important subsets of AML cells, including leukemia stem cells.
    [Biochemical Pharmacology]

    AbstractGraphical Abstract

    Role of Autophagy in Cancer Cell Response to Nucleolar and Endoplasmic Reticulum Stress

    The authors give an overview of the complex role of nucleolar and endoplasmic reticulum stress-response mechanisms in the regulation of autophagy in cancer and cancer treatment.
    [International Journal of Molecular Sciences]

    Full Article

    Therapeutics Receives OK from FDA to Initiate Phase 1 Clinical Studies for Next-Generation Mutant p53 Reactivator, APR-548

    Aprea Therapeutics, Inc. announced that the FDA has accepted the Company’s Investigational New Drug application for APR-548 to treat TP53 mutant myelodysplastic syndromes. APR-548 is a next-generation small molecule reactivator of mutant p53 that is being developed for oral administration.
    [Aprea Therapeutics, Inc.]

    Press Release


    International Chemical Biology Society (ICBS) 2020 Conference

    November 11 – November 13

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    Scientists – Stem Cell Factors in Epithelial Cancers

    The University of Chicago – Location

    Research Fellow – Pancreatic and Liver Cancers

    The Mayo Clinic – Jacksonville, Florida, United States

    Postdoctoral Fellow – Stem Cells and Cancer

    Albert Einstein College of Medicine – New York, New York, United States

    Professor – Center for Molecular Medicine

    The University of Georgia – Athens, Georgia, United States

    Postdoctoral Position – Human Pluripotent Stem Cells, Hematopoiesis and Leukemia

    Icahn School of Medicine at Mount Sinai – New York City, New York, United States

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